Lai, Alex L. Freed, Jack H.
Published in
Biophysical Journal
Entry of coronaviruses into host cells is mediated by the viral spike protein. Previously, we identified the bona fide fusion peptides (FPs) for severe acute respiratory syndrome coronavirus (“SARS-1”) and severe acute respiratory syndrome coronavirus-2 (“SARS-2”) using electron spin resonance spectroscopy. We also found that their FPs induce membr...
Huang, Yihan Harris, Bradley S. Minami, Shiaki A. Jung, Seongwon Shah, Priya S. Nandi, Somen McDonald, Karen A. Faller, Roland
Published in
Biophysical Journal
Sonar, Punam Bellucci, Luca Mossa, Alessandro Heidarsson, Pétur O. Kragelund, Birthe B. Cecconi, Ciro
Binding of ligands is often crucial for function yet the effects of ligand binding on the mechanical stability and energy landscape of proteins are incompletely understood. Here we use a combination of single-molecule optical tweezers and MD simulations to investigate the effect of ligand binding on the energy landscape of acyl-coenzyme A (CoA) bin...
Kunkel, Genevieve Madani, Mohammad White, Simon J. Verardi, Paulo H. Tarakanova, Anna
Published in
Biophysical Journal
The ongoing COVID-19 pandemic is a global public health emergency requiring urgent development of efficacious vaccines. While concentrated research efforts have focused primarily on antibody-based vaccines that neutralize SARS-CoV-2, and several first-generation vaccines have either been approved or received emergency use authorization, it is forec...
Sabareesan, Ambadi Thody Singh, Jogender Roy, Samrat Udgaonkar, Jayant B. Mathew, M.K.
Published in
Biophysical Journal
Wilhelm, Kiera B. Morita, Shumpei McAffee, Darren B. Kim, Sungi O’Dair, Mark K. Groves, Jay T.
Published in
Biophysical Journal
Dyson, H. Jane
Published in
Biophysical Journal
McCoy, Matthew D Hamre, John 3rd Klimov, Dmitri K Jafri, M Saleet
Published in
Biophysical journal
Joyeux, Marc
Published in
Biophysical journal
The chromosomal DNA of bacteria is folded into a compact body called the nucleoid, which is composed essentially of DNA (∼80%), RNA (∼10%), and a number of different proteins (∼10%). These nucleoid proteins act as regulators of gene expression and influence the organization of the nucleoid by bridging, bending, or wrapping the DNA. These so-called ...
Sebastiani, Federico Michlits, Hanna Lier, Bettina Becucci, Maurizio Furtmüller, Paul G. Oostenbrink, Chris Obinger, Christian Hofbauer, Stefan Smulevich, Giulietta
Published in
Biophysical Journal