Published in Biophysical Journal
Entry of coronaviruses into host cells is mediated by the viral spike protein. Previously, we identified the bona fide fusion peptides (FPs) for severe acute respiratory syndrome coronavirus (“SARS-1”) and severe acute respiratory syndrome coronavirus-2 (“SARS-2”) using electron spin resonance spectroscopy. We also found that their FPs induce membr...
Published in Biophysical Journal
Binding of ligands is often crucial for function yet the effects of ligand binding on the mechanical stability and energy landscape of proteins are incompletely understood. Here we use a combination of single-molecule optical tweezers and MD simulations to investigate the effect of ligand binding on the energy landscape of acyl-coenzyme A (CoA) bin...
Published in Biophysical Journal
The ongoing COVID-19 pandemic is a global public health emergency requiring urgent development of efficacious vaccines. While concentrated research efforts have focused primarily on antibody-based vaccines that neutralize SARS-CoV-2, and several first-generation vaccines have either been approved or received emergency use authorization, it is forec...
Published in Biophysical Journal
Published in Biophysical Journal
Published in Biophysical Journal
Published in Biophysical journal
Published in Biophysical journal
The chromosomal DNA of bacteria is folded into a compact body called the nucleoid, which is composed essentially of DNA (∼80%), RNA (∼10%), and a number of different proteins (∼10%). These nucleoid proteins act as regulators of gene expression and influence the organization of the nucleoid by bridging, bending, or wrapping the DNA. These so-called ...
Published in Biophysical Journal
