Wang, Shisheng Wang, Xu Shao, Yujie Shao, Kun Wang, Yang Guo, Xiuhan Dong, Hongxu Zhao, Weijie Li, Yueqing Li, Guangzhe
...
Published in
Bioorganic chemistry
Selaginellins are a type of rare natural products from the genus Selaginella with unusual alkynyl phenol skeletons and extensive biological activities. Previous structural simplification of these natural compounds afforded a series of diaryl acetylene derivatives with hypoxia-inducible factor 1 (HIF-1) inhibitory activity. In this study, we synthes...
Liu, Xu-Ying Yang, Jing-Bo Duan, Ting-Ting Wu, Cheng-Yan Tang, Quan Lu, Zhong-Lin He, Lan Sun, Wan
Published in
Bioorganic chemistry
The development of cationic polymers as non-viral gene vectors has been hurdled by their high toxicity, thus degradable and biocompatible polymers are urgently demanded. Herein, five polyesters (B3a-B3e) were synthesized based on the ring-opening copolymerization between α-allyl-δ-valerolactone and δ-valerolactone derivatives decorated with alkyl o...
Hu, Chun-Mei Wang, Wen-Jing Ye, Yuan-Na Kang, Yu Lin, Jing Wu, Pan-Pan Li, Dong-Li Bai, Li-Ping Xu, Xue-Tao Li, Bao-Qiong
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Published in
Bioorganic chemistry
In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good to moderate α-glucosidase and α-amylase inhibitory activities with IC50 values: 5.11 ± 1.46-90.26 ± 1.85 µM and 4.27 ± 1.51-49.28 ± 2.54 µM as compared to the standard acarbos...
Akunuri, Ravikumar Veerareddy, Vaishnavi Kaul, Grace Akhir, Abdul Unnissa, Tanveer Parupalli, Ramulu Madhavi, Y V Chopra, Sidharth Nanduri, Srinivas
Published in
Bioorganic chemistry
Infections caused due to multidrug resistant organisms have emerged as a constant menace to human health. Even though numerous antibiotics are currently available for treating infectious diseases, a great number of bacterial strains have acquired resistance to many of them. Among these, infections caused due to Staphylococcus aureus are predominant...
Duan, Yulin Deng, Yanfang Bu, Pengfei Guo, Yi Shi, Zhengyi Cao, Yunfang Zhang, Yeting Hu, Hong Hu, Zhengxi Qi, Changxing
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Published in
Bioorganic chemistry
Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperwilsones A-K (1-11), along with five known PPAPs (12-16), were isolated from Hypericum wilsonii. Their structures were established via spectroscopic methods, the careful analysis of calculated and experimental electronic circular dichroism (ECD) spectra, single-crystal X-ray dif...
Zhu, Junjie Li, Ziyang Lu, Haihong Liu, Shengquan Ding, Weijia Li, Jiazhong Xiong, Yahong Li, Chunyuan
Published in
Bioorganic chemistry
The strategy "IEMAHC" (Induction of Endophyte Metabolism by Adding Host Components) was applied to the fermentation of the endophytic fungus Epicoccum sorghinum L28 from Myoporum bontioides by introducing guaiol, an ingredient of M. bontioides, into the cultivation medium, which resulted in the purification of nine new diphenyl ethers, epicoccether...
Jorda, Radek Molitorová, Veronika Pilařová, Eliška Vojáčková, Veronika Řezníčková, Eva Svobodová, Klára Pauk, Karel Imramovský, Aleš Kryštof, Vladimír
Published in
Bioorganic chemistry
The comparative study of new proteasome inhibitors based on salicylic acid-modified pseudo-tripeptides terminated with aldehyde or vinylsulfone is presented. We described the synthesis of 11 pairs of pseudopeptides and their properties related to the proteasome inhibition were determined. The effects of integrated amino acids (combinations of leuci...
Ali, Mahmoud M Ali, Mohamed Gaballa, Akmal S El-Korashy, Sabry A Teleb, Said M
Published in
Bioorganic chemistry
Charge transfer complexes developed during the interaction of Fluconazole drug (FLU) as an electron donor with different types of electron acceptors, including σ-type as iodine (I2), and π-types as 2,3-dinitrosalsylic acid (HDNS), Tetracyanoethylene (TCNE) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The formed complexes were characterized ...
Besada, Pedro Viña, Dolores Costas, Tamara Costas-Lago, María Carmen Vila, Noemí Torres-Terán, Iria Sturlese, Mattia Moro, Stefano Terán, Carmen
Published in
Bioorganic chemistry
A novel class of potential MAO-B inhibitors was designed and synthesized in good yield by combining the pyridazinone moiety with the dithiocarbamate framework, two relevant pharmacophores for drug discovery. The biological results obtained for the different pyridazinone/dithiocarbamate hybrids (compounds 8-14) indicated that most of them reversibly...
Dang, Xin Lei, Shuwen Luo, Shuhua Hu, Yixin Wang, Juntao Zhang, Dongdong Lu, Dan Jiang, Faqin Fu, Lei
Published in
Bioorganic chemistry
Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the...
