Soltani Rad, Mohammad Navid Behrouz, Somayeh Atashbasteh, Esmaeil Hashemi, Seyedeh-Sara
Published in
Bioorganic chemistry
The fabrication, characterization of butyl methyl imidazolium silica sulfate [BMIm]SS as a novel nano hybrid catalyst and its application in synthesis of new ibuprofen (IBP) 1,2-diol mono esters were described. [BMIm]SS catalyzed the reaction of IBP with epoxides to afford the new IBP 1,2-diol mono esters in good to excellent yields. The products w...
Liang, Xiao Huang, Zhong-Hui Ma, Xuan Zheng, Zhi-Hui Zhang, Xue-Xia Lu, Xin-Hua Qi, Shu-Hua
Published in
Bioorganic chemistry
Nine new xanthone-type and anthraquinone-type mycotoxins including austocystins J-N (1-5), 7-chloro versicolorin A (6), 3'-hydroxy-8-O-methyl versicolorin B (7), 8-O-methyl versiconol (8) and 2',3'-dihydroxy versiconol (9), together with 17 known analogues (10-26) were isolated from an extract of the deep-sea-derived fungus Aspergillus puniceus SCS...
Toumi, Amani Boudriga, Sarra Hamden, Khaled Sobeh, Mansour Cheurfa, Mohammed Askri, Moheddine Knorr, Michael Strohmann, Carsten Brieger, Lukas
Published in
Bioorganic chemistry
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3'-oxindoles]. They were obtained by one-pot three component [3 + 2] cycloaddition of stabilized azomethine ylides, generated in situ by condensat...
Magoulas, George E Kalopetridou, Lefkothea Ćirić, Ana Kritsi, Eftichia Kouka, Paraskevi Zoumpoulakis, Panagiotis Chondrogianni, Niki Soković, Marina Prousis, Kyriakos C Calogeropoulou, Theodora
...
Published in
Bioorganic chemistry
A series of new thieno[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their activity against four gram-positive and four gram-negative bacterial and eight fungal species. The majority of the compounds exhibited excellent antimicrobial and antifungal activity, being more potent than the control compounds. Compound 22, beari...
Kausar, Nabeela Ullah, Saeed Khan, Maria Aqeel Zafar, Humaira Atia-Tul-Wahab, Choudhary, M Iqbal Yousuf, Sammer
Published in
Bioorganic chemistry
Celebrex (1), commonly used as an anti-inflammatory drug, was functionalized (compounds 2-9) to identify new α-glucosidase inhibitors. Initially, all the synthesized derivatives were evaluated for anti-inflammatory activity but none was found to be active. Subsequently a random biological screening was carried out. Interestingly many of them were f...
Lin, Lan Lu, Wenyu Dai, Tianzhi Chen, Huan Wang, Tong Yang, Li Yang, Xuelian Liu, Ying Sun, Dequn
Published in
Bioorganic chemistry
Many artemisinin derivatives have good inhibitory effects on malignant tumors. In this work, a novel series of artemisinin derivatives containing piperazine and fluorine groups were designed and synthesized and their structures were confirmed by 1H NMR, 13C NMR and HRMS technologies. The in vitro cytotoxicity against various cancer cell lines was e...
Caciolla, Jessica Picone, Giovanna Farruggia, Giovanna Valenti, Dario Rampa, Angela Malucelli, Emil Belluti, Federica Trezza, Alfonso Spiga, Ottavia Iotti, Stefano
...
Published in
Bioorganic chemistry
A small library of derivatives carrying a polycyclic scaffold recently identified by us as a new privileged structure in medicinal chemistry was designed and synthesized, aiming at obtaining potent MDR reverting agents also endowed with antitumor properties. In particular, as a follow-up of our previous studies, attention was focused on the role of...
Dou, Lei Zhang, Xinxin Zangeneh, Mohammad Mahdi Zhang, Yi
Published in
Bioorganic chemistry
At the moment, metallic nanoparticles especially copper nanoparticles are administrated for the cure of different disorders, such as tumor and cancer. In recent years, many chemotherapeutic supplements have been formulated by copper nanoparticles. In the present study, copper nanoparticles were prepared and synthesized in aqueous medium using Camel...
Mallikarjuna Reddy, Guda Camilo, Alexandre Jr Raul Garcia, Jarem
Published in
Bioorganic chemistry
A new series of pyrrole analogs were developed via the microwave irradiation synthesis. Consequently, got a high yield of the products. As pyrroles are familiar for showing various biological properties, all obtained compounds were screened for their antioxidant properties, most of the compounds showing significant activity. In fact, the motifs 5e,...
Zuo, Jiawei Wang, Shi-Meng Jiang, Xia Cao, Mengxin Zhang, Ziwen Shi, Tianlu Qin, Hua-Li Tang, Wenjian
Published in
Bioorganic chemistry
Acute kidney injury (AKI) is associated with a strong inflammatory response, and inhibiting the response effectively prevents or ameliorates AKI. A series of novel arylpropionic esters were designed, synthesized and evaluated their biological activity in LPS-stimulated RAW264.7 cells. Novel arylpropionic esters bearing multi-functional groups showe...
