Shareef, Mohd Adil Sirisha, Kanugala Sayeed, Ibrahim Bin Khan, Irfan Ganapathi, Thipparapu Akbar, Syed Ganesh Kumar, C Kamal, Ahmed Nagendra Babu, Bathini
Published in
Bioorganic & medicinal chemistry letters
A series of new triazole fused imidazo[2,1-b]thiazole hybrids (9a-u) were designed, synthesized and evaluated as antimicrobial agents. Compounds 9c, 9d, 9e, 9j and 9l showed promising broad spectrum antimicrobial activity. Further, compound 9c exhibited significant anti-biofilm activity with single and mixed biofilm disruption demonstrated by Field...
Subramanian, Govindan Bowen, Scott J Zhu, Yaqi Roush, Nicole Zachary, Theresa Javens, Christopher Williams, Tracey Janssen, Ann Gonzales, Andrea
Published in
Bioorganic & medicinal chemistry letters
In silico virtual screening using the ligand-based ROCS approach and the commercially purchasable compound collection from the ZINC database resulted in the identification of distinctly different and novel acetamide core frameworks with series representatives 1a and 2a exhibiting nanomolar affinity in the kinase domain only hTrkA HTRF biochemical a...
Clark, Charles G Rossi, Karen A Corte, James R Fang, Tianan Smallheer, Joanne M De Lucca, Indawati Nirschl, David S Orwat, Michael J Pinto, Donald J P Hu, Zilun
...
Published in
Bioorganic & medicinal chemistry letters
This manuscript describes the discovery of a series of macrocyclic inhibitors of FXIa with oral bioavailability. Assisted by structure based drug design and ligand bound X-ray crystal structures, the group linking the P1 moiety to the macrocyclic core was modified with the goal of reducing H-bond donors to improve pharmacokinetic performance versus...
Singh, Harpreet Kaur, Manpreet Kaur, Harpreet Sharma, Indu Bhandari, Anmol Kaur, Gurcharan Singh, Palwinder
Published in
Bioorganic & medicinal chemistry letters
Targeting dihydrofolate reductase, here, we report the tumor growth inhibitory activity of substituted acridones. The screening of the molecules over 60 cell line panel of human cancer cells identified (S)-oxiran-2-ylmethyl 9-oxo-9,10-dihydroacridine-4-carboxylate (19) with average GI50 0.3 μM. The specificity of the compound to CCRF-CEM, MOLT-4 an...
Pavić, Kristina Rubinić, Barbara Rajić, Zrinka Fontinha, Diana Prudêncio, Miguel Uzelac, Lidija Kralj, Marijeta Held, Jana Zorc, Branka
Published in
Bioorganic & medicinal chemistry letters
Primaquine homodimers, e.g. symmetric PQ-diamides of dicarboxylic acids containing 4 to 8 carbon atoms, were evaluated against Plasmodium berghei hepatic stages and P. falciparum blood stages, as well as against three cancer cell lines. Novel PQ-homodimers exerted much higher activity against hepatic stages, but less pronounced activity against blo...
McDermott, Lee Koes, David Mohammed, Shabber Iyer, Prema Boby, Melissa Balasubramanian, Venkatakrishnan Geedy, Mackenzie Katt, William Cerione, Richard
Published in
Bioorganic & medicinal chemistry letters
Allosteric inhibitors of glutaminase (GAC), such as BPTES, CB-839 and UPGL00019, have great promise as inhibitors of cancer cell growth, but potent inhibitors with drug-like qualities have been difficult to achieve. Here, a small library of GAC inhibitors based on the UPGL00019 core is described. This set of derivatives was designed to assess if on...
Xie, Yonghui Huang, Haojie Ismail, Ismail Sun, Hongyan Yi, Long Xi, Zhen
Published in
Bioorganic & medicinal chemistry letters
Based on thiolysis of the NBD amine, a H2S-triggered prodrug has been designed and synthesized for localized production of ciprofloxacin under micromolar H2S. Activation of the prodrug can be monitored through fluorescence in real-time. We envision that thiolysis of the NBD amine could be readily used for development of other H2S-triggered prodrugs...
Dong, Yongxi Zhang, Xiaohe Liu, Mingji Yang, Yang Guo, Ting Mao, Yuanhu Zhang, Jiquan Fu, Xiaozhong Zhao, Yonglong Chen, Jinglei
...
Published in
Bioorganic & medicinal chemistry letters
A series of hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites have been synthesized. Compared to the original compound, these prepared compounds exhibited higher water solubility, more appropriate logP and better stability. Importantly, compounds 11b, 11d and 11e showed improved neuroprotective activity against the H2O2...
Manna, Tapasi Pal, Kunal Jana, Kuladip Misra, Anup Kumar
Published in
Bioorganic & medicinal chemistry letters
A series of glycosylated 1,4-substituted triazolyl chalcone derivatives (8a-f and 14a-r) were synthesized in high yield using 1,3-cycloaddition (Click chemistry) of d-glucosyl azides with a variety of propargylated chalcone derivatives followed by de-O-acetylation. The synthesized compounds were evaluated for their cytotoxic potential against the h...
Zhu, Gaofeng Wang, Keren Shi, Jian Zhang, Pengfei Yang, Dan Fan, Xiaotian Zhang, Ziyi Liu, Wenmin Sang, Zhipei
Published in
Bioorganic & medicinal chemistry letters
A series of 2-acetylphenol-donepezil hybrids was designed and synthesized based on multi-target-directed ligands strategy. The biological activities were evaluated by AChE/BChE inhibition and MAO-A/MAO-B inhibition. The results revealed that the tertiary amines and methylene chain length significantly affected the eeAChE inhibitory potency, in part...
