Akhtar, Nosheen Baig, Muhammad Waleed Haq, Ihsan-Ul Rajeeve, Vinothini Cutillas, Pedro Rodriguez
Published in
Biomedicines
Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease. Withanolides, a group of steroidal lactones found in Solanaceae plants are of potential interest due to their reported anticancer activities in dif...
Vargas, Ana Sofia Luís, Ângelo Barroso, Mário Gallardo, Eugenia Pereira, Luísa
Published in
Biomedicines
Psilocybin is a naturally occurring tryptamine known for its psychedelic properties. Recent research indicates that psilocybin may constitute a valid approach to treat depression and anxiety associated to life-threatening diseases. The aim of this work was to perform a systematic review with meta-analysis of clinical trials to assess the therapeuti...
Jaudon, Fanny Baldassari, Simona Musante, Ilaria Thalhammer, Agnes Zara, Federico Cingolani, Lorenzo A
Published in
Biomedicines
Episodic ataxia type 2 (EA2) is an autosomal dominant neurological disorder characterized by paroxysmal attacks of ataxia, vertigo, and nausea that usually last hours to days. It is caused by loss-of-function mutations in CACNA1A, the gene encoding the pore-forming α1 subunit of P/Q-type voltage-gated Ca2+ channels. Although pharmacological treatme...
Bae, Yun Seon Kim, Jung Yi, Jeesoo Park, Soon Cheol Lee, Hae-Youn Cho, Sung-Jin
Published in
Biology
Regeneration is a biological process restoring lost or amputated body parts. The capability of regeneration varies among organisms and the regeneration of the central nervous system (CNS) is limited to specific animals, including the earthworm Perionyx excavatus. Thus, it is crucial to establish P. excavatus as a model system to investigate mechani...
Barraza-Guerrero, Sergio I Meza-Herrera, César A García-De la Peña, Cristina González-Álvarez, Vicente H Vaca-Paniagua, Felipe Díaz-Velásquez, Clara E Sánchez-Tortosa, Francisco Ávila-Rodríguez, Verónica Valenzuela-Núñez, Luis M Herrera-Salazar, Juan C
...
Published in
Biology
The general bacterial microbiota of the soft tick Ornithodoros turicata found on Bolson tortoises (Gopherus flavomarginatus) were analyzed using next generation sequencing. The main aims of the study were to establish the relative abundance of bacterial taxa in the tick, and to document the presence of potentially pathogenic species for this tortoi...
Kuppusamy, Giva Kong, Chee Kei Segaran, Ganeswaran Chandra Tarmalingam, Eliyarajan Herriman, Max Ismail, Mohd Fathil Mehmood Khan, Tahir Low, Liang Ee Goh, Bey-Hing
Published in
Biology
Black soldier fly (BSF) larva is an attractive animal feed replacer due to its noticeable nutritional content. However, the conventional rearing method often resulted in BSF with undesirably high heavy metal residues that are harmful to animals. In this work, putrefied Sesbania grandiflora (S. Grandiflora) leaves were employed as feed to rear BSF l...
Chen, Po-Jen Kuo, Liang-Mou Wu, Yi-Hsiu Chang, Yu-Chia Lai, Kuei-Hung Hwang, Tsong-Long
Published in
Biomedicines
Activation of hepatic stellate cells (HSCs) is a critical pathogenic feature of liver fibrosis and cirrhosis. BAY 41-2272 is a canonical non-nitric oxide (NO)-based soluble guanylyl cyclase (sGC) stimulator that triggers cyclic guanosine monophosphate (cGMP) signaling for attenuation of fibrotic disorders; however, the impact of BAY 41-2272 on HSC ...
Bernal-Monterde, Vanesa Casas-Deza, Diego Letona-Giménez, Laura de la Llama-Celis, Natalia Calmarza, Pilar Sierra-Gabarda, Olivia Betoré-Glaria, Elena Martínez-de Lagos, María Martínez-Barredo, Lucía Espinosa-Pérez, María
...
Published in
Biomedicines
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with abnormal liver function tests. We hypothesized that early altered liver biochemistries at admission might have different clinical relevance than subsequent changes during hospitalization. A single-center retrospective study was conducted on 540 consecutive hospitalized ...
Santoso, Fiorency Farhan, Ali Castillo, Agnes L Malhotra, Nemi Saputra, Ferry Kurnia, Kevin Adi Chen, Kelvin H-C Huang, Jong-Chin Chen, Jung-Ren Hsiao, Chung-Der
...
Published in
Biomedicines
The heart is the most important muscular organ of the cardiovascular system, which pumps blood and circulates, supplying oxygen and nutrients to peripheral tissues. Zebrafish have been widely explored in cardiotoxicity research. For example, the zebrafish embryo has been used as a human heart model due to its body transparency, surviving several da...
Almansa-Ordonez, Alexandra Bellido, Raquel Vassena, Rita Barragan, Montserrat Zambelli, Filippo
Published in
Biology
Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through oxidative phosphorylation. During this process, reactive oxygen species (ROS) are produced, and an imbalance in their concentrations can induce oxidative stress (OS), causing cellular damage. However, mitochondria and ROS play also an important role in cellular hom...
