Tossetta, Giovanni Fantone, Sonia Montanari, Eva Marzioni, Daniela Goteri, Gaia
Published in
Antioxidants (Basel, Switzerland)
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers demonstrated that oxidative stress is involved in tumour occurrence, growth and development. Nuclear factor erythroid 2-related factor 2 (NRF2) is an important transcription f...
Park, Jun-Kyu Do, Yuno
Published in
Biology
As the advantages of wind energy as an eco-friendly strategy for power generation continue to be revealed, the number of offshore wind farms also increases worldwide. However, wind turbines can induce behavioral and physiological responses in animals by emitting various types of noises. In this study, we investigated the behavioral, physiological, ...
Proulx, Jessica Ghaly, Maria Park, In-Woo Borgmann, Kathleen
Published in
Biomedicines
With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so th...
Lisencu, Lorena Alexandra Trancă, Sebastian Bonci, Eduard-Alexandru Pașca, Andrei Mihu, Carina Irimie, Alexandru Tudoran, Oana Balacescu, Ovidiu Lisencu, Ioan Cosmin
Published in
Biomedicines
Breast cancer is one of the leading causes of death in women worldwide. One subtype of breast cancer is the triple-negative, which accounts for 15% of total breast cancer cases and is known for its poor prognosis. The main cause of death is due to metastasis. Circulating tumor cells (CTCs) play a key role in the metastatic process. CTCs arise eithe...
Wu, Rui Karagiannopoulos, Alexandros Eliasson, Lena Renström, Erik Luan, Cheng Zhang, Enming
Published in
Biomedicines
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca2+ (CaV) channels in which the gamma-4 subunit (CaVγ4) is required for the beta-cell to maint...
Ushio, Ryosuke Hiroi, Miki Matsumoto, Ari Mori, Kazumasa Yamamoto, Nobuharu Ohmori, Yoshihiro
Published in
Biomedicines
Combined treatment of human oral squamous cell carcinoma (OSCCs) with DNA methyltransferase inhibitors (DNMTis), histone methyltransferase inhibitors (HMTis), and histone deacetylase inhibitors (HDACis), and the molecular mechanisms underlying their anticancer effects, have not been fully elucidated. Herein, we investigated the cytotoxic effects of...
Sarkar, Ryan Pampaloni, Francesco
Published in
Biomedicines
Spaceflight affects the body on every level. Reports on astronaut health identify bone marrow remodelling and dysfunction of the innate immune system as significant health risks of long-term habitation in space. Microgravity-induced alterations of the bone marrow induce physical changes to the bone marrow stem cell niche. Downstream effects on inna...
Virgilio, Eleonora De Marchi, Fabiola Contaldi, Elena Dianzani, Umberto Cantello, Roberto Mazzini, Letizia Comi, Cristoforo
Published in
Biomedicines
Nowadays, there is a need for reliable fluid biomarkers to improve differential diagnosis, prognosis, and the prediction of treatment response, particularly in the management of neurogenerative diseases that display an extreme variability in clinical phenotypes. In recent years, Tau protein has been progressively recognized as a valuable neuronal b...
Nucera, Eleonora Parrinello, Giuseppe Gangemi, Sebastiano Buonomo, Alessandro Aruanno, Arianna Lohmeyer, Franziska Michaela Inchingolo, Riccardo Rizzi, Angela
Published in
Biomedicines
Hypersensitivity reactions (HRs) to contrast media (CM) are a major problem. We compared differences of HRs to iodinated contrast media (ICM) versus gadolinium-based contrast media (GBCM), collecting data on prevalence, type, latency and severity. Secondly, the predisposition to perform new contrast tests, use of premedication and possible appearan...
Papoutsopoulou, Stamatia Morris, Lorna Bayliff, Andrew Mair, Thomas England, Hazel Stagi, Massimiliano Bergey, François Alam, Mohammad Tauqeer Sheibani-Tezerji, Raheleh Rosenstiel, Philip
...
Published in
Biomedicines
The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic strain to study the functional implication of xenogeneic (human) RelA(p65) protein introduced into the mo...