Wang, Ye Liu, Jie Liu, Zheng Chen, Jing Hu, Xuemei Hu, Yimeng Yuan, Yin Wu, Guijun Dai, Zhe Xu, Yancheng
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Spalt-like (Sall) proteins are a class of transcription factors. The role of Sall2 in beta cells remain poorly understood. Here, we aimed to explore whether Sall2 involved in lipotoxicity-mediated dysfunction and apoptosis in pancreatic NIT-1 beta cells. Our results showed that high concentrations of palmitic acid (PA) led to impaired cell viabilit...
Salem, Gamal A Shaban, Ahmed Diab, Hussain A Elsaghayer, Wesam A Mjedib, Manal D Hnesh, Aomassad M Sahu, Ravi P
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The current studies were sought to determine effects of antioxidant potential of aqueous and methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used analgesic paracetamol (PCM) induced hepatotoxicity. Groups of rats were treated with or without PCM (1500 mg/kg), PLAE and PLME (300 mg/kg) and n-acetylcysteine (NAC, ...
Martins, Jeanette S, Brijesh
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Stress renders an individual to experience mental pressure and exhaustion which brings about feelings of anxiety, depression, anger and/or other negative emotions. Depression affects a person's state of mind, behaviour, health and is often associated with suicide. The use of anti-depressant drugs as therapeutic agents is associated with symptoms su...
Zununi Vahed, Sepideh Moghaddas Sani, Hakimeh Rahbar Saadat, Yalda Barzegari, Abolfazl Omidi, Yadollah
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Diabetes is a genetic- and epigenetic-related disease from which a large population worldwide suffers. Some genetic factors along with various mutations related to the immune system for disease mechanism(s) have contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification of the initiation and/or pr...
Wu, Fengbo Li, Sijia Zhang, Nan Huang, Wei Li, Xiang Wang, Manyi Bai, Ding Han, Bo
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
These results indicate that hispidulin induces autophagy and inhibits apoptosis induced by high glucose in murine podocytes. This study will illuminate future developments in DN-targeted therapy.
Cui, Zhili An, Xin Li, Jingxia Liu, Qiaozhen Liu, Wenli
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in tumor development and progression. Recent studies reported that lncRNA MIR22HG could play important roles in hepatocellular carcinoma and lung cancer progression. However, the expression and underlying mechanism of MIR22HG in endometrial cancer (EC) remain un...
Wu, Yan Liu, Yonghui Pan, Yitong Lu, Chunxiao Xu, Haonan Wang, Xiaozhi Liu, Tingting Feng, Kai Tang, Yiqun
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
MiR-135a inhibits cardiac fibrosis via miR-135a- TRPM7-collagen production pathway.
Zhang, Liang Bao, Dongmei Li, Peng Lu, Zhidong Pang, Long Chen, Zhirong Guo, Haohui Gao, Zhihui Jin, Qunhua
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
PE particle-induced downregulation of SIRT1 enhances ER stress and promotes osteoclast proliferation and bone resorption through regulation of c-Fos, NFATc1, and the MAPK and NF-κB signaling pathways.
Deng, Hua-Fei Wang, Sha Li, Lian Zhou, Qin Guo, Wan-Bei Wang, Xiao-Li Liu, Mei-Dong Liu, Ke Xiao, Xian-Zhong
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Puerarin prevented LPS-induced vascular endothelial injury, the mechanism of which might be related to the suppression of NF-κB activation and subsequently altered levels of inflammatory factors and coagulation-related factors.
Cai, Tiantian Zhang, Chengzhe Zhao, Ziming Li, Siyi Cai, Haobin Chen, Xiaodong Cai, Dake Liu, Wei Yan, Yan Xie, Kaifeng
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gastric Cancer is one of the most common types of cancer. And the occurrence of gastric carcinoma is an evolutionary histopathological stage. As a result, further research of GPL, which is a borderline of gastric cancer, is indispensable for preventing the formation and development of gastric carcinoma. Several studies have demonstrated a correlati...
