Yang, Tao Wang, Siyi Li, Hongmei Zhao, Qun Yan, Shili Dong, Miao Liu, Dan Chen, Xuanqin Li, Rongtao
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
P-glycoprotein (P-gp) plays a significant role in multi-drug resistance (MDR) of cancer cells, resulting in the failure of cancer chemotherapy. Lathyrane diterpene was a class of promising MDR modulator. The phytochemical investigation on the seeds of Euphorbia lathyris L. aff ;orded four new lathyrol-type diterpenoids (1-4), together with seventeen...
Bharti, Mukesh K Bhat, Irfan A Pandey, Sriti Shabir, Uffaq Peer, Bilal A Indu, B Bhat, Abas Rashid Kumar, G Sai Amarpal, Chandra, Vikash
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The objective of this study was to compare the therapeutic potential of canine bone marrow derived mesenchymal stem cells (BM MSCs) augmented mesh scaffold for wound healing potential in guinea pig before and after cryopreservation. Bone marrow aspirate was obtained from healthy dogs and culture was expanded in vitro. MSCs augmented mesh scaffold w...
Xu, Ruiyuan Hu, Jieping
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Prostate cancer (PC), which has high morbidity and mortality among elderly men, is becoming the most common malignancy in men. The progression of PC is associated with several aspects including apoptosis, proliferation and metastasis. C-Jun N-terminal kinase (JNK) is a member of mitogen-activated protein kinases (MAPKs), which play vital roles in r...
Shi, Jinfeng Tan, Shulian Song, Liangmei Song, Liangsong Wang, Yusheng
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been verified as an oncogenic gene in human cancers, including nasopharyngeal carcinoma (NPC). However, the role of XIST in NPC remains to be largely uncovered, as well as its underlying mechanism. Expression of XIST, miR-148a-3p and ADAM17 was detected using qPCR and western ...
Teles, Kaian Fernandes, Vinicius Silva, Isabel Leite, Manuela Grisolia, Cesar Lobbia, Vincenzo R van Ingen, Hugo Honorato, Rodrigo Lopes-de-Oliveira, Paulo Treptow, Werner
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chromatin state is highly dependent on the nucleosome binding proteins. Herein, we used a multipronged approach employing biophysical and in vivo experiments to characterize the effects of Nucleosome Binding Peptides (NBPeps) on nucleosome and cell activity. We performed a series of structure-based calculations on the nucleosome surface interaction...
Li, Xiang Liu, Linlin Cao, Zhiwen Li, Wen Li, Hui Lu, Cheng Yang, Xueqin Liu, Yuanyan
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gut microbiota plays an important role in the gut and have become a hotspot of recent research interests. Commensal microbiota in gut exert a variety of effects on the host, from shaping the structure and function of the gut and the immune system to the modulation of nutrient status of the host and the treatment outcomes of some drugs. Gut microbio...
Szekalska, Marta Sosnowska, Katarzyna Tomczykowa, Monika Winnicka, Katarzyna Kasacka, Irena Tomczyk, Michał
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cynaroside (CYN) is the predominant derivative of luteolin in aerial parts of Bidens tripartita which has been used in folk medicine as a diaphoretic, diuretic, antiseptic and anti-inflammatory agent. In our study, alginate (ALG), which is an anionic polymer with bioadhesive properties, was used as a CYN carrier, and multiple hydrogel formulations ...
Xia, Chengxing Chen, Liu Sun, Wanghong Yan, Ruping Xia, Mengyuan Wang, Yuehu Yang, Delin
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Paris forrestii is a unique plant found in Tibet and Yunnan, China, and total saponins from Paris forrestii (PCT3) contain anticancer steroid glycosides. RNA expression plays an important role in various biological processes. However, the cytotoxicity effects and mechanisms of PCT3 in relation to prostate cancer (PCa) cells have not yet been report...
Yue, Yun Li, Yi-Qi Fu, Shu Wu, Yu-Ting Zhu, Ling Hua, Liang Lv, Jun-Yuan Li, Ye-Li Yang, Dan-Li
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Pulmonary artery smooth muscle cell (PASMC) proliferation contributes to pulmonary vascular remodeling, which ultimately leads to pulmonary arterial hypertension (PAH). Osthole has been previously shown to inhibit tumor cell growth. Our previous experiments demonstrated that osthole could prevent monocrotaline-induced PAH and pulmonary artery remod...
Zhao, Yu Tao, Qilei Wu, Jian Liu, Huanhai
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Deleted in malignant brain tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich (SRCR) protein, predominantly expressed in nasal mucosal epithelial cells. In previous experiments, we found large amounts of DMBT1 present in the nasal cavity mucosa of allergic rhinitis (AR) patients. However, the exact role of DMBT1 in AR remains unclear. ...
