Seo, Su Yeon Ryu, Yeonhee
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Acupuncture stimulation can protect the brain against caffeine-induced sleep disruption. This study investigated whether electroacupuncture stimulation acupuncture point HT7 alleviates sleep disruption by regulating mBDNF and ER stress in the medial septum. Acute exposure to caffeine (15 mg/kg, i.p.) increased the wake time and decreased REM sleep,...
Wang, Yule Wu, Huimin Sheng, Hongda Wang, Yingchao Li, Xuecai Wang, Yi Zhao, Lu
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ischemic stroke is a leading cause of death worldwide, and it remains an urgent task to develop novel and alternative therapeutic strategies for the disease. We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting functional recovery in ischemic stroke mice. However, the ac...
Chuang, Yu-Chung Lin, Hsin-Yi Wang, Jann-Tay Yang, Jia-Ling Lin, Chi-Ying Huang, Sung-Hsi Chen, Yee-Chun Chang, Shan-Chwen
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Different methods are used to determine the minimum inhibitory concentration (MIC) for daptomycin. The threshold is unknown for the free drug area under the concentration-time curve to MIC ratio (fAUC/MIC) of daptomycin using broth microdilution (BMD) to predict outcome of vancomycin-resistant enterococcus (VRE) bacteremia. The MIC testing method w...
Brogyányi, Tereza Kaplánek, Robert Kejík, Zdeněk Hosnedlová, Božena Antonyová, Veronika Abramenko, Nikita Veselá, Kateřina Martásek, Pavel Vokurka, Martin Richardson, Des R
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising therapeutic methods. In this study, we tested the cytotoxicity of novel azulene hydrazide-hydrazone-based chelators against pancrea...
Zhang, Qixiong Li, Shanshan Chen, Fengyu Zeng, Rui Tong, Rongsheng
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Numerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non-alcoholic fatty liver, Alzheimer's disease, type 2 diabetes, atherosclerosis, and malignant tumors....
Mesas, Cristina Garcés, Víctor Martínez, Rosario Ortiz, Raúl Doello, Kevin Dominguez-Vera, Jose M Bermúdez, Francisco Porres, Jesús M López-Jurado, María Melguizo, Consolación
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Amorphous calcium phosphate nanoparticles (ACP NPs) exhibit excellent biocompatibility and biodegradability properties. ACP NPs were functionalized with two coumarin compounds (esculetin and euphorbetin) extracted from Euphorbia lathyris seeds (BC-ACP NPs) showing high loading capacity (0.03% and 0.34% (w/w) for esculetin and euphorbetin, respectiv...
Zhang, Jinping Zheng, Yongchun Hong, Bo Ma, Lina Zhao, Yingchun Zhang, Shuai Sun, Shuwen Ding, Qiteng Wang, Yue Liu, Wencong
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Exposure to ultraviolet (UV) radiation is a key cause of skin inflammation and photodamage in the environment. Dihydroquercetin composite nanofiber membrane (CPD) is a nano-scale membrane cloth prepared by electrospinning technology. The results in this study showed that CPD could enhance the activities of endogenous antioxidant enzymes such as SOD...
Byerley, Lauri O Chang, Hsiao-Man Lorenzen, Brittany Guidry, Jessie Hardman, W Elaine
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Nutraceutical foods, like walnuts which are rich in immunonutrients, can have medicinal benefits. Dietary walnuts have been shown to slow or prevent tumor growth in mice genetically programmed to grow breast or prostate tumors. This study investigated whether walnuts could exert the same preventable effect in a transplantable carcinoma rat model. E...
Khan, Faizullah Khan, Haroon Khan, Ajmal Yamasaki, Masao Moustaid-Moussa, Naima Al-Harrasi, Ahmed Rahman, Shaikh Mizanoor
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
White adipose tissue expands rapidly due to increased adipocyte number (hyperplasia) and size (hypertrophy), which results in obesity. Adipogenesis is a process of the formation of mature adipocytes from precursor cells. Additionally, obesity-related metabolic complications, such as fatty liver and insulin resistance, are linked to adipogenesis. On...
Luo, Zhenye Liu, Changshun Hu, Yannan Xia, Ting Zhang, Baoping Chen, Feilong Tan, Xiaomei Zheng, Zezhong
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Acute bacterial diarrhea is a severe global problem with a particularly high incidence rate in children. The microecology inhabiting the intestinal mucosa is the key factor leading to diarrhea. Gegen Qinlian decoction (GQD) is used to treat bacterial diarrhea, however, its underlying mechanism remains unclear. Thus, this study aimed to clarify the ...
