Su, Ying-Shih Kuo, Min Zhan Kuo, Yi Ting Huang, Shu-Wei Lee, Chia-Jung Su, Zheng-Yuan Ni, Yu-Hui Li, Dian-Kun Wu, Tien-Yuan
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cryptotanshinone (CPT) and dihydrotanshinone (DHT) are diterpenoid anthraquinone compounds extracted from traditional Chinese herbal medicine (TCM). Recent studies have shown that CPT regulates the signal transduction pathways via microRNA (miRNA) alterations. However, few studies have investigated the role of DHT in miRNA alterations affecting cel...
Chen, Kuan-Hung Chai, Han-Tan Chen, Chih-Hung Huang, Chi-Ruei Chiang, John Y Sung, Pei-Hsun Chu, Yi-Ching Yip, Hon-Kan
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
This study tested whether combined cyclosporin-A (CsA) and melatonin (Mel) was superior to either one on protecting the brain against ischemia (occluded left-middle-cerebral-artery for 90-min)-reperfusion (for 14 days) injury. Neuro-2a cells (N2a) were categorized into groups 1 (N2a), 2 (N2a-IR), 3 (N2a-IR-Mel), 4 (N2a-IR-CsA) and 5 (N2a-IR-CsA-Mel...
Akbari Dilmaghnai, Nader Shoorei, Hamed Sharifi, Guive Mohaqiq, Mahdi Majidpoor, Jamal Dinger, Marcel E Taheri, Mohammad Ghafouri-Fard, Soudeh
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various glycoproteins that collaborate and bind with each other to produce a bioactive polymer. Alterations in the composition and configuration of ECM elements influence the cellul...
Ashraf, Muhammad Usman Salman, Hafiz Muhammad Khalid, Muhammad Farhan Khan, Muhammad Haider Farooq Anwar, Saima Afzal, Samia Idrees, Muhammad Chaudhary, Safee Ullah
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hepatitis C is an inflammatory liver disease caused by the single-stranded RNA (ssRNA) hepatitis C virus (HCV). The genetic diversity of the virus and quasispecies produced during replication have resulted in viral resistance to direct-acting antivirals (DAAs) as well as impediments in vaccine development. The recent adaptation of CRISPR-Cas as an ...
Song, Lihong Ge, Tongqi Li, Zeqin Sun, Jinfeng Li, Gao Sun, Yi Fang, Liang Ma, Ying Jie Garred, Peter
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Complement is an important innate immune defence machinery. Once dysregulated, it is often linked to pathogenesis of diverse autoimmune diseases. Artesunate (ART) is a well-known anti-malarial compound. Recently, ART has been highlighted by its potential therapeutic effects on certain complement-related autoimmune diseases. However, the underlying ...
Babaei, Ghader Gholizadeh-Ghaleh Aziz, Shiva Rajabi Bazl, Masoumeh Khadem Ansari, Mohammad Hassan
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cancer is considered as the main challenge of human communities, and it annually imposes a significant economic burden on society. Natural products have been used for treatment of many diseases including inflammation, infections, neurological disorders, atherosclerosis, asthma and cancer for many years. Sesquiterpene lactones (STLs) refers to a gro...
Lin, Haiyingjie Chen, Xiaoting Zhang, Chengyong Yang, Tingting Deng, Zhendong Song, Yuwei Huang, Lanlan Li, Fuxiang Li, Qingchu Lin, Shaoqiang
...
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
EF24, a synthetic analogue of curcumin, was developed as an anti-tumor compound to induce apoptosis, inhibit proliferation and metastasis in various cancers. However, whether EF24 induces ferroptosis in osteosarcoma cells or not, and its underlying mechanism remains largely elusive. After EF24 combining with or without other compounds treatments, m...
Habib, Hosam M Ibrahim, Sahar Zaim, Aamnah Ibrahim, Wissam H
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Iron overload is increasingly implicated as a contributor to the pathogenesis of COVID-19. Indeed, several of the manifestations of COVID-19, such as inflammation, hypercoagulation, hyperferritinemia, and immune dysfunction are also reminiscent of iron overload. Although iron is essential for all living cells, free unbound iron, resulting from iron...
Lv, Enjun Sheng, Jiaqi Yu, Chengpeng Rao, Dean Huang, Wenjie
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
As a class of new and crucial molecules involved in the regulation of biological function, long noncoding RNA (lncRNA) have obtained widespread attention in recent days. While it was thought that lncRNA would be redundant in the past, it is proved that lncRNA identify a class of molecular that regulate the homeostasis including hepatocellular carci...
Paterek, Aleksandra Sochanowicz, Barbara Oknińska, Marta Śmigielski, Witold Kruszewski, Marcin Mackiewicz, Urszula Mączewski, Michał Leszek, Przemysław
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Exacerbations of chronic heart failure (CHF) are often treated with catecholamines to provide short term inotropic support, but this strategy is associated with long-term detrimental hemodynamic effects and increased ventricular arrhythmias (VA), possibly related to increased heart rate (HR). We hypothesized that ivabradine may prevent adverse effe...
