Fallah, Maryam Davoodvandi, Amirhossein Nikmanzar, Shahin Aghili, Sarehnaz Mirazimi, Seyed Mohammad Ali Aschner, Michael Rashidian, Amir Hamblin, Michael R. Chamanara, Mohsen Naghsh, Navid
...
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Silymarin contains a group of closely-related flavonolignan compounds including silibinin, and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been shown to protect the liver in both experimental models and clinical studies. The chemopreventive activity of silymarin has shown some efficacy against cancer both in ...
Rajan, Durairaj Karthick Mohan, Kannan Zhang, Shubing Ganesan, Abirami Ramu
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dieckol [C36H22O18], is a naturally occurring phlorotannin found in some brown algal species. Dieckol is gaining more attention in the scientific community for its potential biological activities. It has been exhibited a broad spectrum of therapeutic functions including anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprot...
Marques-Magalhães, Ângela Graça, Inês Miranda-Gonçalves, Vera Henrique, Rui Lopez, Marie Arimondo, Paola B Jerónimo, Carmen
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Renal Cell Carcinoma (RCC) is on the top 10 of the most incident cancers worldwide, being a third of patients diagnosed with advanced disease, for which no curative therapies are currently available. Thus, new effective therapeutic strategies are urgently needed. Herein, we tested the antineoplastic effect of newly synthesized 3-nitroflavanones (ML...
García-Baos, Alba Puig-Reyne, Xavier García-Algar, Óscar Valverde, Olga
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Foetal alcohol spectrum disorder (FASD) is the umbrella term used to describe the physical and mental disabilities induced by alcohol exposure during development. Early alcohol exposure induces cognitive impairments resulting from damage to the central nervous system (CNS). The neuroinflammatory response accompanied by neurodegenerative mechanisms ...
Esmail, Mohammed Anwar, Shehata Kandeil, Mohammed El-Zanaty, Ali Mahmoud Abdel-Gabbar, Mohammed
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Obesity is increasing rapidly across the globe. It is widely accepted that natural products with a long safety background may modulate obesity. The current work aimed to investigate the effect of Nigella sativa, atorvastatin, or L-Carnitine on high-fat diet-induced obesity in white male albino rats. A regular basal diet was fed to 7 rats, and a hig...
Guo, Rui Zhao, Mengfan Liu, Hui Su, Rina Mao, Qin Gong, Leilei Cao, Xu Hao, Yu
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Xijiao Dihuang decoction combined with Yinqiao powder (XDD-YQP) is a classical combination formula; however, its therapeutic effects in treating influenza viral pneumonia and the pharmacological mechanisms remain unclear. The therapeutic effect of XDD-YQP in influenza viral pneumonia was evaluated in mice. Subsequently, an everted gut sac model cou...
Ranjbar, Reza Vahdati, Saeed Niazi Tavakoli, Sara Khodaie, Reza Behboudi, Hossein
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
In recent years, an overwhelming amount of evidence has positively recommended a significant role of microbiota in human health and disease. Microbiota also plays a crucial role in the initiation, preparation, and function of the host immune response. Recently, it has been shown that short-chain fatty acids (SCFAs) are the primary metabolites of th...
Tseng, Yu-Ting Chen, Mo Lai, Richard Oieni, Francesca Smyth, Graham Anoopkumar-Dukie, Shailendra St John, James Ekberg, Jenny
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Transplantation of olfactory ensheathing cells (OECs) is a promising approach for repairing the injured nervous system that has been extensively trialed for nervous system repair. However, the method still needs improvement and optimization. One avenue of improving outcomes is to stimulate OEC migration into the injury site. Liraglutide is a glucag...
Kai-Xing, Liu Cheng, Cheng Rui, Li Zheng-Wei, Shi Wen-Wen, Tan Peng, Xu
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Long noncoding RNAs (lncRNAs) are noncoding RNAs more than 200 nucleotides in length. A growing number of reports indicate that lncRNAs play a key role in multiple cancers by serving as oncogenes or tumor suppressor genes. MAGI2 antisense RNA 3 (MAGI2-AS3) is ubiquitously expressed in human cancers, and the level of MAGI2-AS3 expression is associat...
Badshah, Syed Lal Faisal, Shah Muhammad, Akhtar Poulson, Benjamin Gabriel Emwas, Abdul Hamid Jaremko, Mariusz
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Flavonoids are natural phytochemicals known for their antiviral activity. The flavonoids acts at different stages of viral infection, such as viral entrance, replication and translation of proteins. Viruses cause various diseases such as SARS, Hepatitis, AIDS, Flu, Herpes, etc. These, and many more viral diseases, are prevalent in the world, and so...
