Su, Li Tu, Ye Kong, De-Pei Chen, Da-Gui Zhang, Chen-Xi Zhang, Wan-Nian Zhuang, Chun-Lin Wang, Zhi-Bin
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate C...
Liu, Shan-Shan Wu, Fei Jin, Yue-Mei Chang, Wei-Qin Xu, Tian-Min
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Epigenetic mechanisms, such as acetylation, methylation, and succinylation, play pivotal roles in the regulation of multiple normal biological processes, including neuron regulation, hematopoiesis, bone cell maturation, and metabolism. In addition, epigenetic mechanisms are closely associated with the pathological processes of various diseases, suc...
Fu, Jie Tao, Tao Li, Zuoxiao Chen, Yangmei Li, Jinglun Peng, Lilei
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Epilepsies are a diverse group of neurological disorders, which are characterized by spontaneous recurrent seizures. Although a wide range of pathogenic mechanisms such as alterations in ion channels, inflammation and neuronal loss have been reported to be implicated in the epileptogenesis, the underlying pathogenesis of epilepsy remains unclear cu...
Yan, Caochong Zhou, Yunxiang Chen, Qiang Luo, Yi Zhang, John H Huang, Hefeng Shao, Anwen
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
In current aging societies, diabetes mellitus and neurodegenerative diseases represented by Alzheimer's disease are highly prevalent among adults, especially the elderly all over the world. It is worth noting that a substantial body of evidence suggests diabetes contributes to accelerated neurodegenerative processes and the decline of cognition. Ov...
Xun, Chengfeng Ge, Lite Tang, Feng Wang, Lu Zhuo, Yi Long, Lang Qi, Jiaomei Hu, Li Duan, Da Chen, Ping
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Mesenchymal stromal cells (MSCs) have been used for the treatment of neuronal injury and neurodegenerative diseases. Their underlying mechanism may involve increased secretion of paracrine factors, which promotes tissue repair. Presently, exosomes have been regarded as important components of paracrine secretion and paracrine factors. MSC exosomes ...
Sritawan, Nataya Prajit, Ram Chaisawang, Pornthip Sirichoat, Apiwat Pannangrong, Wanassanan Wigmore, Peter Welbat, Jariya Umka
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Methotrexate (MTX) is a chemotherapeutic drug commonly used to treat cancers that has an adverse effect on patients' cognition. Metformin is a primary treatment for type 2 diabetes mellitus that can pass through the blood-brain barrier. Metformin has neuroprotective actions, which can improve memory. In the present study, we examined the ability of...
Xu, Peijia Luo, Haiqing Kong, Ying Lai, Wing-Fu Cui, Liao Zhu, Xiao
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Tumor neoantigen has a high degree of immunogenicity. As one of the emerging methods of tumor immunotherapy, the vaccine developed against it has served to clinical trials of various solid tumors, especially in the treatment of melanoma. Currently, a variety of immunotherapy methods have been applied to the treatment of the tumor. However, other th...
Hu, Chenxi Hui, Kaiyuan Jiang, Xiaodong
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Antiangiogenic drugs have become a standard therapeutic regimen for advanced non-small cell lung cancer (NSCLC); however, many issues remain to be solved. Identifying specific markers to predict patient response to antiangiogenic drugs to ensure therapeutic efficacy would increase their clinical benefit. MicroRNAs (miRNAs) are involved in the proce...
Fu, Jingwen Wu, Zhaoyi Liu, Jianfeng Wu, Tianfu
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Vitamin C is an electron donor and is involved in a variety of biochemical reactions in stem cell and cancer stem cell, as well as collagen synthesis and the regulation of hypoxia-inducible factor synthesis, which two affect extracellular matrix remodelling and hence cancer metastasis. Specific doses of vitamin C can stop cancer cell glycolysis and...
Chen, Xishan Liang, Renba Zhu, Xiaodong
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Nasopharyngeal carcinoma (NPC) is a common malignant tumor in Southern China and South-East Asia. Regardless of initiative high response to radiotherapy, parts of patients still have relapses and metastases. It is reported that epidermal growth factor receptor (EGFR) is highly expressed in most of NPC and is a poor prognostic factor. Targeting EGFR...
