Jin, Weiyue Xue, Yurun Xue, Yucong Han, Xue Song, Qiongtao Zhang, Jianping Li, Ziliang Cheng, Jie Guan, Shengjiang Sun, Shijiang
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Tannic acid (TA), a group of polyphenolic compounds, has multiple anticancer, antimutagenic, antioxidant and anti-inflammatory activities. However, the effects of TA on arsenic trioxide (ATO)-induced nephrotoxicity are still relatively unknown. This study investigated the protective effects and potential mechanisms of TA on ATO-induced nephrotoxici...
Balkrishna, Acharya Solleti, Siva Kumar Singh, Hoshiyar Tomer, Meenu Sharma, Niti Varshney, Anurag
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Asthma is a chronic allergic respiratory disease with limited therapeutic options. Here we validated the potential anti-inflammatory, anti-asthmatic and immunomodulatory therapeutic properties of calcio-herbal ayurvedic formulation, Divya-Swasari-Ras (DSR) in-vivo, using mouse model of ovalbumin (OVA) induced allergic asthma. HPLC analysis identifi...
Mao, Chen-Xue Li, Min Zhang, Wei Zhou, Hong-Hao Yin, Ji-Ye Liu, Zhao-Qian
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Platinum-based chemotherapy remains the cornerstone of treatment for many malignancies. However, although therapeutic efficiency varies greatly among individuals, there is a lack of pharmacogenomic biomarkers that can be used in clinical settings to identify chemosensitive patients and allow stratification. With the development of high-throughput s...
Shen, Qin Zheng, Jiao Wang, Xueling Hu, Wen Jiang, Yongjie Jiang, Yongliang
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Long non-coding RNAs small nucleolar RNA host gene 5 (lncRNA SNHG5) plays well-defined roles in the malignant progression. However, the roles of SNHG5 in chronic obstructive pulmonary disease (COPD) progression remain unclear. In the present study, SNHG5 expression was low expressed in COPD tissues and positively correlated with low forced expirato...
Huang, Zengshu Zhou, Jing Leung, Wing Ting Gober, Hans Jürgen Pan, Xinyao Li, Chuyu Li, Lisha Wang, Ling
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The Hippo-Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ), originally identified as a regulator of tissue generation and tumorigenesis, has been proven to have a pivotal position in immunity. Its multi-faceted roles in regulating immunity cover both intrinsic mechanism of immune cells and the crosstalk with no...
Xu, Yaqi Zhou, Qian Feng, Xiaoli Dai, Yibo Jiang, Yang Jiang, Wen Liu, Xiaoli Xing, Xiangling Wang, Yongjing Ni, Yihong
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disulfiram (DSF) is an FDA approved anti-alcoholism drug in use for more than 60 years. Recently, antitumor activity of the DSF/copper (DSF/Cu) complex has been identified. Its anti-multiple myeloma activity, however, has barely been investigated. In the present study, our results demonstrated that the DSF/Cu complex induced apoptosis of MM cells a...
Zhou, Shubo Zhou, Yongchun Yu, Jiaji Du, Yaxi Tan, Yong Ke, Yingmei Wang, Juan Han, Benyong Ge, Feng
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with growing prevalence. Currently available therapies for treating IPF are not desirable due to the limited efficacy and multiple side effects. Ophiocordyceps lanpingensis is one strain of entomogenous fungi, which has been collected from the eastern part of the Himalayas. This study reve...
Wu, Weiqi Yang, Bin Qiao, Yang Zhou, Qing He, Huan He, Ming
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Kaempferol (Kae), a flavonoid, has been found in fruits and other vegetables, possesses many biological activities. 14-3-3 protein exerts protection on various types of injured tissues and cells. Doxorubicin (Dox) causes excessive reactive oxygen species (ROS) generation, which induces endotheliotoxicity and cardiotoxicity. We hypothesized that Kae...
Pierce, Marsha L French, Jeffrey A Murray, Thomas F
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Arginine vasopressin (AVP) and oxytocin (OT) are nonapeptides that bind to G-protein coupled receptors and influence social behaviors. Consensus mammalian AVP and OT (Leu8-OT) sequences are highly conserved. In marmosets, an amino acid change in the 8th position of the peptide (Pro8-OT) exhibits unique structural and functional properties. There is...
de Lima, Rosália Maria Tôrres Dos Reis, Antonielly Campinho de Oliveira Santos, José Victor de Oliveira Ferreira, José Roberto de Oliveira Filho, José Williams Gomes Soares Dias, Ana Carolina de Menezes, Ag-Anne Pereira Melo da Mata, Ana Maria Oliveira Ferreira de Alencar, Marcus Vinícius Oliveira Bar... de Jesus Aguiar Dos Santos Andrade, Tere...
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
[6]-Gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] is a phenolic substance reported for several ethnopharmacological usage by virtue of its antioxidant, antiemetic, anti-inflammatory and anticancer properties. This study assessed the antitumoral effects of [6]-Gingerol in primary cells of Sarcoma 180 as well as in peripheral bloo...
