Mei, Jiyang Vasan, Aditya Magaram, Uri Takemura, Kenjiro Chalasani, Sreekanth H. Friend, James
Published in
Biomedical Microdevices
Three-dimensional cell agglomerates are broadly useful in tissue engineering and drug testing. We report a well-free method to form large (1.4-mm) multicellular clusters using 100-MHz surface acoustic waves (SAW) without direct contact with the media or cells. A fluid couplant is used to transform the SAW into acoustic streaming in the cell-laden m...
Zagklavara, Foteini Jimack, Peter K Kapur, Nikil Querin, Osvaldo M Thompson, Harvey M
Published in
Biomedical microdevices
A surrogate-enabled multi-objective optimisation methodology for a continuous flow Polymerase Chain Reaction (CFPCR) systems is presented, which enables the effect of the applied PCR protocol and the channel width in the extension zone on four practical objectives of interest, to be explored. High fidelity, conjugate heat transfer (CHT) simulations...
Sheidaei, Zohreh Akbarzadeh, Pooria Nguyen, Nam-Trung Kashaninejad, Navid
Published in
Biomedical microdevices
Keeping the oxygen concentration at the desired physiological limits is a challenging task in cellular microfluidic devices. A good knowledge of affecting parameters would be helpful to control the oxygen delivery to cells. This study aims to provide a fundamental understanding of oxygenation process within a hydrogel-based microfluidic device cons...
Teoh, Boon Yew Lim, Yang Mooi Chong, Wu Yi Subramaniam, Menaga Tan, Zi Zhang Misran, Misni Suk, Vicit Rizal Eh Lo, Kwok-Wai Lee, Poh Foong
Published in
Biomedical Microdevices
Isolation of exosome from culture medium in an effective way is desired for a less time consuming, cost saving technology in running the diagnostic test on cancer. In this study, we aim to develop an inertial microfluidic channel to separate the nano-size exosome from C666-1 cell culture medium as a selective sample. Simulation was carried out to o...
Liu, Song Dong, Fulin Zhang, Duohuai Zhang, Jinchang Wang, Xiaoling
Published in
Biomedical Microdevices
Biofilms are microbial colonies encased in an extracellular polymer matrix self-secreted through bacterial proliferation and differentiation. Biofilms exist almost everywhere such as sewers, rivers and oceans. In the fluid environment, the formation of biofilms is closely related to the relevant parameters of the flow field, such as the shear stres...
Zhang, Yongshun Liu, Xu Liu, Guanxi Ji, Xuan Yang, Huiyuan Liu, Zhenhu
Published in
Biomedical Microdevices
To achieve cancer screening in any appointed position in 3D regions of the gastrointestinal (GI) tract such as esophagus, stomach and colon, a highly integrated dual hemisphere capsule robot (DHCR) with a novel three-layer nested structure is proposed. Based on tracking effect, in which the robotic axis is likely to be approximately coincident with...
Guo, Xudong Li, Shengnan Hao, Youguo Luo, Zhongyu Yan, Xiangci
Published in
Biomedical Microdevices
The poses of robotic endoscopic capsules are indispensable for further follow-up examinations, potential targeted drug delivery, and closed-loop controlling of active locomotion. A novel tracking method using the multiple magnetic excitations with frequency division has been investigated. The multiple excitation coils can simultaneously work at dif...
Brooks, Zachary Kim, Kanghyun Zhao, Kai Goswami, Tarun Hussain, Saber Dixon, Angela R.
Published in
Biomedical Microdevices
While there are many chip models that simulate the air-tissue interface of the respiratory system, only a few represent the upper respiratory system. These chips are restricted to unidirectional flow patterns that are not comparable to the highly dynamic and variable flow patterns found in the native nasal cavity. Here we describe the development o...
Zhou, Yufeng
Published in
Biomedical Microdevices
Acoustofluidics inside the microchannel has already found its wide applications recently. Acoustic streaming and radiation force are two underlying mechanisms that determine the trajectory of microparticles and cells in the manipulation. Critical particle size of viscous effects is found to be about 1.6 µm in the conventional rectangular microchann...
Ghosh, Ananya Thodi, Fidal Vallam Sengupta, Sudeshna Kannan, Sivasundari Krishnan, Lalitha Bhattacharya, Enakshi
Published in
Biomedical Microdevices
