Li, Xiao Zhou, Yun Wickramaratne, Bhagya Yang, Yijia Pappas, Dimitri
Published in
Biomedical Microdevices
Microfluidic, flow cytometry, and immunomagnetic methods for cancer cell isolation have heavily relied on the Epithelial Cellular Adhesion Molecule (EpCAM) for affinity separation. While EpCAM has been used extensively for circulating tumor cell isolation, it cannot be used to isolate non-epithelial cells. The human transferrin receptor (CD71) can ...
Pokki, Juho Zisi, Iliana Schulman, Ester Indana, Dhiraj Chaudhuri, Ovijit
Published in
Biomedical Microdevices
Changes in extracellular matrix stiffness impact a variety of biological processes including cancer progression. However, cells also actively remodel the matrices they interact with, dynamically altering the matrix mechanics they respond to. Further, cells not only react to matrix stiffness, but also have a distinct reaction to matrix viscoelastici...
Shaik, Subhan Saminathan, Aarthi Sharma, Deepak Krishnaswamy, Jagdish A Mahapatra, D Roy
Published in
Biomedical Microdevices
A continuous rise in the wastes from industrial effluents, bio-waste, and pharmaceuticals has deteriorated surface water and drinking water sources. Standard laboratory tests of total coliform are time-consuming and logistically inefficient for field data generation. Better and portable sensing technologies are needed. This paper reports an electri...
de Oliveira, Viviane Klassen Camargo, Bruno Dias Alexandrino, Fabiana Morello, Luis Gustavo Marchini, Fabricio Klerynton Aoki, Mateus Nóbrega Blanes, Lucas
Published in
Biomedical Microdevices
This article describes the fabrication of a low-cost Polymerase Chain Reaction (PCR) instrument to detect diseases. In order to reduce the instrument price and simplify construction we developed an alternative fabrication process, transforming conventional printed circuit boards (PCB) in heating elements, avoiding the use of aluminum heating/coolin...
Tronolone, James J. Lam, Johnny Agrawal, Anant Sung, Kyung
Published in
Biomedical Microdevices
Given the increased recognition of the importance of physiologically relevant microenvironments when designing in vitro assays, microphysiological systems (MPS) that mimic the critical function and structure of tissues and organs have gained considerable attention as alternatives to traditional experimental models. Accordingly, the field is growing...
Esmaeel, Abdelhady Ahmed, Khaled I. E. FathEl-Bab, Ahmed M. R.
Published in
Biomedical Microdevices
Measuring viscoelastic properties of soft tissues becomes a new biomarker in the medical diagnosis field. It can help in early diagnosis and related fields, such as minimally-invasive-surgery (MIS) applications and cell mechanics. The current work presents a tactile sensor for measuring the damping coefficient of the soft tissues. The proposed sens...
Liu, Chen Zhang, Yu Xiao, Liang Ge, Xin Öner, Fetullah Cumhur Xu, Hongguang
Published in
Biomedical Microdevices
Cervical degenerative disease is a common and frequently occurring disease, which seriously affects the health and quality of the life of patients worldwide. Anterior cervical decompression and interbody fusion is currently recognized as the gold standard for the treatment of degenerative cervical spondylosis. Polyetheretherketone (PEEK) has become...
Lee, Donghee Greer, Sydney E. Kuss, Mitchell A. An, Yang Dudley, Andrew T.
Published in
Biomedical Microdevices
Alginate hydrogel beads are a common platform for generating 3D cell cultures in biomedical research. Simple methods for bead generation using a manual pipettor or syringe are low-throughput and produce beads showing high variability in size and shape. To address these challenges, we designed a 3D printed bead generator that uses an airflow to clea...
Hong, Seong Hyeon Shu, Jung-Il Wang, Yi Baysal, Oktay
Published in
Biomedical Microdevices
This paper presents a framework for automated optimization of double-heater convective PCR (DH-cPCR) devices by developing a computational fluid dynamics (CFD) simulation database and artificial neural network (ANN) model. The optimization parameter space that includes the capillary tube geometries and the heater sizes of DH-cPCR is established, an...
Zhou, Shi Xing, Yi Yuan, Xing Wu, Guanlan Zhu, Xiaolin Wu, Dongmei
Published in
Biomedical Microdevices
The effects of six polycyclic aromatic hydrocarbons (PAHs) on the activity of V79 cells were studied by using a miniature electrochemical system based on graphene oxide quantum dots and multiwall carbon nanotubes modified anodized screen printed carbon electrode. The cytotoxicity sequence of PAHs on V79 cells was different with guanine/xanthine (G/...
