Laville, Colin Fetita, Catalin Gille, Thomas Brillet, Pierre-Yves Nunes, Hilario Bernaudin, Jean-François Genet, Martin
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Biomechanics and modeling in mechanobiology
Interstitial lung diseases, such as idiopathic pulmonary fibrosis (IPF) or post-COVID-19 pulmonary fibrosis, are progressive and severe diseases characterized by an irreversible scarring of interstitial tissues that affects lung function. Despite many efforts, these diseases remain poorly understood and poorly treated. In this paper, we propose an ...
Moulton, Michael J Secomb, Timothy W
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Biomechanics and modeling in mechanobiology
The course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-...
Zhang, Jiangbo Zhang, Aobo Han, Qing Liu, Yang Chen, Hao Ma, Mingyue Li, Yongyue Chen, Bingpeng Wang, Jincheng
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Biomechanics and modeling in mechanobiology
Metal block augmentations are common solutions in treating bone defects of total knee revision. However, the stress shielding and poor osteointegration resulted from metal block application could not be neglected in bone defects restoration. In this study, a novel porous metal block was designed with topology optimization to improve biomechanical p...
Gil, Antonio Navarro, Roberto Quintero, Pedro Mares, Andrea
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Biomechanics and modeling in mechanobiology
Mechanical circulatory support using ventricular assist devices is a common technique for treating patients suffering from advanced heart failure. The latest generation of devices is characterized by centrifugal turbopumps which employ magnetic levitation bearings to ensure a gap clearance between moving and static parts. Despite the increasing use...
Jafarinia, Alireza Melito, Gian Marco Müller, Thomas Stephan Rolf-Pissarczyk, Malte Holzapfel, Gerhard A Brenn, Günter Ellermann, Katrin Hochrainer, Thomas
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Biomechanics and modeling in mechanobiology
Type B aortic dissection (TBAD) carries a high risk of complications, particularly with a partially thrombosed or patent false lumen (FL). Therefore, uncovering the risk factors leading to FL thrombosis is crucial to identify high-risk patients. Although studies have shown that morphological parameters of the dissected aorta are related to FL throm...
Miller, Laura Penta, Raimondo
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Biomechanics and modeling in mechanobiology
Within this work, we investigate how physiologically observed microstructural changes induced by myocardial infarction impact the elastic parameters of the heart. We use the LMRP model for poroelastic composites (Miller and Penta in Contin Mech Thermodyn 32:1533-1557, 2020) to describe the microstructure of the myocardium and investigate microstruc...
Belyaev, Aleksey V Kushchenko, Yulia K
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Biomechanics and modeling in mechanobiology
Platelet adhesion and activation are essential initial processes of arterial and microvascular hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The process relies on von Willebrand factor (VWF)-a linear multimeric protein of blood plasma plays a pivotal role in mechanochemical regulation of shear-induced platelet ag...
Shirakashi, Ryo Sisario, Dmitri Taban, Danush Korsa, Tessa Wanner, Sophia B Neubauer, Julia Djuzenova, Cholpon S Zimmermann, Heiko Sukhorukov, Vladimir L
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Biomechanics and modeling in mechanobiology
Erythrocyte ghost formation via hemolysis is a key event in the physiological clearance of senescent red blood cells (RBCs) in the spleen. The turnover rate of millions of RBCs per second necessitates a rapid efflux of hemoglobin (Hb) from RBCs by a not yet identified mechanism. Using high-speed video-microscopy of isolated RBCs, we show that elect...
Schenk, Denis Zysset, Philippe
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Biomechanics and modeling in mechanobiology
The microstructure of trabecular bone is known to adapt its morphology in response to mechanical loads for achieving a biomechanical homeostasis. Based on this form-function relationship, previous investigators either simulated the remodeling of bone to predict the resulting density and architecture for a specific loading or retraced physiological ...
Torner, B Frank, D Grundmann, S Wurm, F-H
Published in
Biomechanics and modeling in mechanobiology
The improvement and development of blood-contacting devices, such as mechanical circulatory support systems, is a life saving endeavor. These devices must be designed in such a way that they ensure the highest hemocompatibility. Therefore, in-silico trials (flow simulations) offer a quick and cost-effective way to analyze and optimize the hemocompa...
