Shen, Shuilin Zhang, Zimeng Huang, Haixiao Yang, Jing Tao, Xinyue Meng, Zhengjie Ren, Hao Li, Xueming
Published in
Biomaterials Research
Background Immunogenic cell death (ICD) induced by different cancer treatments has been widely evaluated to recruit immune cells and trigger the specific antitumor immunity. However, cancer associated fibroblasts (CAFs) can hinder the invasion of immune cells and polarize the recruited monocytes to M2-type macrophages, which greatly restrict the ef...
Fu, Shiyao Wang, Mingao Li, Bin Li, Xu Cheng, Jianjun Zhao, Haitian Zhang, Hua Dong, Aijun Lu, Weihong Yang, Xin
...
Published in
Biomaterials Research
Background Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficie...
Narwade, Mahavir Shaikh, Aazam Gajbhiye, Kavita R. Kesharwani, Prashant Gajbhiye, Virendra
Published in
Biomaterials Research
The non-specificity of standard anticancer therapies has profound detrimental consequences in clinical treatment. Therapeutic specificity can be precisely achieved using cutting-edge ligands. Small synthetic oligonucleotide-ligands chosen through Systematic evolution of ligands by exponential enrichment (SELEX) would be an unceasing innovation in u...
Wang, Shanjie Chen, Kegong Wang, Ye Wang, Zeng Li, Zhaoying Guo, JunChen Chen, Jianfeng Liu, Wenhua Guo, Xiaohui Yan, Guangcan
...
Published in
Biomaterials Research
Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has been considered a promising drug and gene delivery system to ...
Xu, Xueli Liu, Ao Liu, Shuangqing Ma, Yanling Zhang, Xinyu Zhang, Meng Zhao, Jinhua Sun, Shuo Sun, Xiao
Published in
Biomaterials Research
Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures and dynamics of nanomedicine can be affected by a variety of non-covalent interactions, so it is essential to ensure the self-assembly process at atomic level. Molecular dynamics (MD) simulation is a key technology to link microcosm and macroscale. Along with t...
Kim, Sang Jun Kim, Ji Eun Choe, Goeun Song, Da Hyun Kim, Sun Jeong Kim, Tae Hee Yoo, Jin Kim, Soo Hyun Jung, Youngmee
Published in
Biomaterials Research
Background Self-assembled peptide (SAP)-substance P (SP) hydrogels can be retained in the joint cavity longer than SP alone, and they can alleviate inflammation and ameliorate cartilage regeneration in knee osteoarthritis (OA). We conducted a preclinical study using diverse animal models of OA and an in vitro study using human synoviocytes and pati...
Hu, Datao Wen, Jinpeng Zhao, Xinxin Liu, Kailai Zhang, Yuchen Bu, Yizhuo Wang, Ke
Published in
Biomaterials Research
Background Antibacterial activity and on-demand removability are key characteristics governing the effectiveness of clinic wound dressing. However, the excellent tissue adhesion of new dressings is often overemphasized without a detailed discussion of dressing replacement. Besides, the inherent antibacterial ability of dressings is beneficial for p...
Kim, Jaeheung Kang, Moon Sung Jun, Seung Won Jo, Hyo Jung Han, Dong-Wook Kim, Chang-Seok
Published in
Biomaterials Research
Background Regeneration of defective neurons in central nervous system is a highlighted issue for neurodegenerative disease treatment. Various tissue engineering approaches have focused on neuritogenesis to achieve the regeneration of damaged neuronal cells because damaged neurons often fail to achieve spontaneous restoration of neonatal neurites. ...
Phan, Thanh Huyen Shi, Huaikai Denes, Christopher E. Cole, Alexander J. Wang, Yiwei Cheng, Yuen Yee Hesselson, Daniel Roelofs, Susan H. Neely, Graham Gregory Jang, Jun-Hyeog
...
Published in
Biomaterials Research
Background Respiratory diseases are the 2 nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced for lung diseases in the last 40 years, due to the lack of reliable lung models that enable rapid, cost-effective, and high-throughput testing....
Xu, Yamei Hu, Qiyuan Wei, Zongyun Ou, Yi Cao, Youde Zhou, Hang Wang, Mengna Yu, Kexiao Liang, Bing
Published in
Biomaterials Research
Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, resea...
