Corrigendum to "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/proge...
...Published in Biomaterials
Corrigendum to "A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in fu...
...Published in Biomaterials
RNA-assisted self-assembly of monomeric antigens into virus-like particles as a recombinant vaccine platform.
Published in Biomaterials
Representing highly ordered repetitive structures of antigen macromolecular assemblies, virus-like particles (VLPs) serve as a high-priority vaccine platform against emerging viral infections, as alternatives to traditional cell culture-based vaccines. RNAs can function as chaperones (Chaperna) and are extremely effective in promoting protein foldi...
3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibro...
...Published in Biomaterials
Generating microliver tissues to recapitulate hepatic function is of increasing importance in tissue engineering and drug screening. But the limited availability of primary hepatocytes and the marked loss of phenotype hinders their application. Human induced hepatocytes (hiHeps) generated by direct reprogramming can address the shortage of primary ...
Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer.
Published in Biomaterials
The presence of immunosuppressive innate immune cells such as myeloid derived suppressor cells (MDSCs), Ly6C-high monocytes, and tumor-associated macrophages (TAMs) at a tumor can inhibit effector T cell and NK cell function. Immune checkpoint blockade using anti-PD-1 antibody aims to overcome the immune suppressive environment, yet only a fraction...
Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric...
...Published in Biomaterials
Biological scaffolds derived from decellularized tissues are being investigated as a promising approach to repair volumetric muscle losses (VML). Indeed, extracellular matrix (ECM) from decellularized tissues is highly biocompatible and mimics the original tissue. However, the development of fibrosis and the muscle stiffness still represents a majo...
Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages.
Published in Biomaterials
Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function. While macrophages are known regulators of fibroblast behavior, how their phenotype influences ECM assembly and the progressio...
Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles.
Published in Biomaterials
In cancer, angiogenesis is a critical phenomenon of nascent blood vessel development to facilitate the oxygen and nutrient supply prerequisite for tumor progression. Therefore, targeting tumors at the angiogenesis step may be significant to prevent their advanced progression and metastasis. Although angiogenesis inhibitors can limit the further gro...
Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment.
...Published in Biomaterials
A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic therapy (PDT) reagent chlorine ...
Photodynamic/ photothermal therapy enhances neutrophil-mediated ibrutinib tumor delivery for potent tumor immunotherapy:...
Published in Biomaterials
Neutrophil-mediated drug-delivery systems have gained widespread attention owing to their superior efficacy in cancer therapy. Neutrophils, the most abundant white cells in peripheral blood, are known to migrate to inflamed tumors. Here, we elaborate on a novel strategy to enhance tumor infiltration of neutrophils by photodynamic/photothermal thera...
