Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand
Published in Biomaterials
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Tunable bioactivity and mechanics of collagen-based tissue engineering constructs: A comparison of EDC-NHS, genipin and ...
Published in Biomaterials
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NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering.
...Published in Biomaterials
Stem cell-based tissue engineering has the potential to use as an alternative for autologous tissue grafts; however, the contribution of the scaffold degradation along with the transplanted stem cells to in vivo tissue regeneration remains poorly understood. Near-infrared (NIR) fluorescence imaging has great potential to monitor implants while avoi...
Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat ...
Published in Biomaterials
Palmitic acid-modified bovine serum albumin (PAB) was synthetized and found to own remarkable scavenger receptor-A (SR-A) targeting ability in vitro and in vivo, through which activated macrophages took up PAB nanoparticles (PAB NPs) 9.10 times more than bovine serum albumin nanoparticles (BSA NPs) and PAB NPs could delivery anti-inflammatory drugs...
Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem.
Published in Biomaterials
Tumor hypoxia-responsive size-switchable nanosystems for precise delivery of drug into deep tumor show great prospects for killing cancer cells with high specificity and minimal invasiveness. However, the development of versatile nanosystems is still a challenge. Herein, for the first time, we report a novel hypoxia-responsive copper metal-organic ...
The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to pre...
...Published in Biomaterials
Myocardial fibrosis, resulting from ischemic injury, increases tissue resistivity in the infarct area, which impedes heart synchronous electrical propagation. The uneven conduction between myocardium and fibrotic tissue leads to dys-synchronous contraction, which progresses towards ventricular dysfunction. We synthesized a conductive poly-pyrrole-c...
Calcium phosphate nanoneedle based gene delivery system for cancer genetic immunotherapy.
...Published in Biomaterials
Ovarian cancer has become one of the most common gynecological cancers with a high mortality. However, conventional surgery together with combination chemotherapy is difficult to achieve ideal therapeutic effect. Although genetic immunotherapy is applied to active immune responses against cancer, the absence of efficient in vivo gene delivery techn...
Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au-Ag hollow nanotriangles....
Published in Biomaterials
Nowadays, limited deep tumor penetration and lower therapeutic effect are still the major obstacle in nanomedicines for cancer therapy. Here, we developed high-efficiency nanocomposites, SO2 prodrug (BTS) loaded Au-Ag hollow nanotriangles (Au-Ag-BTS HTNs), which could not only synergistically upregulate Bax expression in mitochondria, but also be t...
Non-apoptotic cell death induced by opening the large conductance mechanosensitive channel MscL in hepatocellular carcin...
...Published in Biomaterials
Most anticancer therapies trigger apoptosis to eliminate malignant cells. However, the majority of malignant cancer cells are resistant to apoptosis due to genetic mutations or heterogeneity. Here, we report that opening the pore of the bacterial large conductance mechanosensitivity channel (MscL) provides a novel approach of inducing non-apoptotic...
Dual-engineered, "Trojanized" macrophages bio-modally eradicate tumors through biologically and photothermally deconstru...
Published in Biomaterials
To engineer tumor-tropic cells as drug delivery vehicles is a promising strategy to improve therapeutic specificity and efficacy for cancer treatment. However, conventional genetically engineered cell-based drug delivery systems are often capable of initiating single-mode therapy, and lack precise spatiotemporal control over the release of therapeu...
