Sun, Si Li, Entao Zhao, Gan Tang, Jie Zuo, Qianfei Cai, Larry Xu, Chuanfei Sui, Cheng Ou, Yangxue Liu, Chang
...
Published in
Biomaterials
The ongoing SARS-CoV-2 pandemic represents a brutal reminder of the continual threat of mucosal infectious diseases. Mucosal immunity may provide robust protection at the predominant sites of SARS-CoV-2 infection. However, it remains unclear whether respiratory mucosal administration of DNA vaccines could confer protective immune responses against ...
Zhang, Yunxiu Jia, Qingyan Nan, Fuchun Wang, Jian Liang, Ke Li, Jian Xue, Xiaokuang Ren, Haohui Liu, Weimin Ge, Jiechao
...
Published in
Biomaterials
Carbon dots (CDs) have emerged as promising nanomaterials for bioimaging-guided photodynamic therapy (PDT). However, designing red-emissive CDs (RCDs) with tunable type I and type II reactive oxygen species (ROS) generation to simultaneously meet PDT applications in aerobic and hypoxic scenarios still remain major challenges. Herein, three types of...
Zhang, Hongjie Chen, Weijian Wang, Jing Du, Wenxiang Wang, Bibo Song, Lei Hu, Yuan Ma, Xiaopeng
Published in
Biomaterials
Reactive oxygen species (ROS) as well-known endogenous stimuli has been widely used to activate drug delivery systems (DDSs) for tumor-specific therapy. Unfortunately, endogenous ROS in the tumor microenvironment (TME) is not enough to achieve effective therapeutic efficacy and cancer cells have adapted to high oxidative stress by upregulating glut...
Wong, Francisca Siu Yin Tsang, Ken Kin Chan, Barbara Pui Lo, Amy Cheuk Yin
Published in
Biomaterials
Treatments of vision-threatening retinal diseases are often hampered by drug delivery difficulties. Polyelectrolytically-coated alginate encapsulated-cell therapy (ECT) systems have shown therapeutic efficacy through prolonged in vivo drug delivery but still face various biocompatibility, viability, drug delivery and mechanical stability issues in ...
Chen, Dapeng Liang, Chen Qu, Xinyu Zhang, Tian Mou, Xiaozhou Cai, Yu Wang, Wenjun Shao, Jinjun Dong, Xiaochen
Published in
Biomaterials
The microenvironment in solid tumors drives the fate of cancer cells to ferroptosis, yet the underlying mechanism remains incompletely understood. Herein, we report a metal-free polymer photosensitizer (BDPB) as a new type ferroptosis inducer of starved cancer cells. The polymer consists of boron difluoride dipyrromethene dye as the photosensitizin...
Nikam, Shantanu P Hsu, Yen-Hao Marks, Jessica R Mateas, Catalin Brigham, Natasha C McDonald, Samantha M Guggenheim, Dana S Ruppert, David Everitt, Jeffrey I Levinson, Howard
...
Published in
Biomaterials
Intraperitoneal adhesions (IAs) are a major complication arising from abdominal repair surgeries, including hernia repair procedures. Herein, we fabricated a composite mesh device using a macroporous monofilament polypropylene mesh and a degradable elastomer coating designed to meet the requirements of this clinical application. The degradable elas...
Kim, Hyeonji Jang, Je-Hwan Han, Wonil Hwang, Hyun-Jeong Jang, Jinah Kim, Joon Young Cho, Dong-Woo
Published in
Biomaterials
Regenerative medicine requires both tissue restoration and ease of compliance for clinical application. Considering this, sticky tissue sealants have been shown to have great potentials over surgical suturing and wound treatment. However, tissue sealants currently used pose challenges such as uncontrollable adhesion formation, mechanical mismatch, ...
Koo, Kyeong-Mo Go, Young-Hyun Kim, Seong-Min Kim, Chang-Dae Do, Jeong Tae Kim, Tae-Hyung Cha, Hyuk-Jin
Published in
Biomaterials
Pluripotent stem cells (PSCs) exist in naïve or primed states based on their origin. For in vitro culture, these PSCs require different supplements and growth factors. However, owing to their similar phenotypic features, identifying both cell types without harming cellular functions is challenging. This study reports an electrochemical method that ...
Zang, Jie Yang, Yushan Zheng, Xiao Yang, Yan Zhao, Yuge Miao, Zhe Zhang, Tingting Gu, Jingjing Liu, Yiqiong Yin, Weimin
...
Published in
Biomaterials
L-arginine metabolism is essential for the activation, survival, and effector function of the T lymphocytes and critical in eliminating tumors via T-cell-mediated immunotherapy, such as immune checkpoint blockade (ICB). Unfortunately, efficient delivery of hydrophilic L-arginine to the tumor microenvironment (TME) has met tremendous difficulties be...
Cho, Chanmi Oh, Hyeryeon Lee, Jin Sil Kang, Li-Jung Oh, Eun-Jeong Hwang, Yiseul Kim, Seok Jung Bae, Yong-Soo Kim, Eun-Jeong Kang, Ho Chul
...
Published in
Biomaterials
Osteoarthritis (OA) is a degenerative joint disorder associated with inflammation, functional disability, and high socioeconomic costs. The development of effective therapies against inflammatory OA has been limited owing to its complex and multifactorial nature. The efficacy of Prussian blue nanozymes coated with Pluronic (PPBzymes), US Food and D...
