Colzani, Maria Malcor, Jean-Daniel Hunter, Emma J Bayraktar, Semih Polkinghorne, Murray Krieg, Thomas Cameron, Ruth Best, Serena Farndale, Richard W Sinha, Sanjay
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Published in
Biomaterials
In this study, we investigated the role of cardiomyocyte (CM) and endothelial cell (EC) specific interactions with collagen in the assembly of an operational myocardium in vitro. Engineered cardiac patches represent valuable tools for myocardial repair following infarction and are generally constituted of a suitable biomaterial populated by CMs and...
Puetzer, Jennifer L. Ma, Tianchi Sallent, Ignacio Gelmi, Amy Stevens, Molly M.
Published in
Biomaterials
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Han, Weijing El Botty, Rania Montaudon, Elodie Malaquin, Laurent Deschaseaux, Frederic Espagnolle, Nicolas Marangoni, Elisabetta Cottu, Paul Zalcman, Gérard Parrini, Maria Carla
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Published in
Biomaterials
Bone is the most frequent metastasis site for breast cancer. As well as dramatically increasing disease burden, bone metastases are also an indicator of poor prognosis. One of the main challenges in investigating bone metastasis in breast cancer is engineering in vitro models that replicate the features of in vivo bone environments. Such in vitro m...
You, Yaqi Kobayashi, Kazuya Colak, Burcu Luo, Piaopiao Cozens, Edward Fields, Laura Suzuki, Ken Gautrot, Julien
Published in
Biomaterials
Epicardial placement of mesenchymal stromal cells (MSCs) is a promising strategy for cardiac repair post-myocardial infarction, but requires the design of biomaterials to maximise the retention of donor cells on the heart surface and control their phenotype. To this end, we propose the use of a poly(2-alkyl-2-oxazoline) (POx) derivative, based on 2...
Yin, Heyong Strunz, Franziska Yan, Zexing Lu, Jiaju Brochhausen, Christoph Kiderlen, Stefanie Clausen-Schaumann, Hauke Wang, Xiumei Gomes, Manuela E Alt, Volker
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Published in
Biomaterials
Lin, Dan Cai, Bolei Wang, Le Cai, Lisha Wang, Zihao Xie, Jirong Lv, Qian-Xin Yuan, Yuan Liu, Changsheng Shen, Steve Gf
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Published in
Biomaterials
Hwang, Beom Jeung Jang, Yohan Kwon, Soon Bin Yu, Ji Eun Lim, Jongkwan Roh, Young Hoon Seong, Baik L
Published in
Biomaterials
Representing highly ordered repetitive structures of antigen macromolecular assemblies, virus-like particles (VLPs) serve as a high-priority vaccine platform against emerging viral infections, as alternatives to traditional cell culture-based vaccines. RNAs can function as chaperones (Chaperna) and are extremely effective in promoting protein foldi...
Lu, Zuyan Priya Rajan, Shiny Amala Song, Qianqian Zhao, Yu Wan, Meimei Aleman, Julio Skardal, Aleksander Bishop, Colin Atala, Anthony Lu, Baisong
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Published in
Biomaterials
Generating microliver tissues to recapitulate hepatic function is of increasing importance in tissue engineering and drug screening. But the limited availability of primary hepatocytes and the marked loss of phenotype hinders their application. Human induced hepatocytes (hiHeps) generated by direct reprogramming can address the shortage of primary ...
Zhang, Yining Hughes, Kevin R Raghani, Ravi M Ma, Jeffrey Orbach, Sophia Jeruss, Jacqueline S Shea, Lonnie D
Published in
Biomaterials
The presence of immunosuppressive innate immune cells such as myeloid derived suppressor cells (MDSCs), Ly6C-high monocytes, and tumor-associated macrophages (TAMs) at a tumor can inhibit effector T cell and NK cell function. Immune checkpoint blockade using anti-PD-1 antibody aims to overcome the immune suppressive environment, yet only a fraction...
Magarotto, Fabio Sgrò, Alberto Dorigo Hochuli, Agner Henrique Andreetta, Marina Grassi, Michele Saggioro, Mattia Nogara, Leonardo Tolomeo, Anna Maria Francescato, Riccardo Collino, Federica
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Published in
Biomaterials
Biological scaffolds derived from decellularized tissues are being investigated as a promising approach to repair volumetric muscle losses (VML). Indeed, extracellular matrix (ECM) from decellularized tissues is highly biocompatible and mimics the original tissue. However, the development of fibrosis and the muscle stiffness still represents a majo...
