Catanzaro, Giuseppina Besharat, Zein Mersini Carai, Andrea Jäger, Natalie Splendiani, Elena Colin, Carole Po, Agnese Chiacchiarini, Martina Citarella, Anna Gianno, Francesca
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Published in
Biomarker Research
Background Pediatric low-grade gliomas (pLGGs), particularly incompletely resected supratentorial tumours, can undergo progression after surgery. However to date, there are no predictive biomarkers for progression. Here, we aimed to identify pLGG-specific microRNA signatures and evaluate their value as a prognostic tool. Methods We identified and v...
Köhnke, Thomas Liu, Xilong Haubner, Sascha Bücklein, Veit Hänel, Gerulf Krupka, Christina Solis-Mezarino, Victor Herzog, Franz Subklewe, Marion
Published in
Biomarker Research
Background Immunotherapy of acute myeloid leukemia has experienced considerable advances, however novel target antigens continue to be sought after. To this end, unbiased approaches for surface protein detection are limited and integration with other data types, such as gene expression and somatic mutational burden, are poorly utilized. The Cell Su...
Wu, Haofeng Liu, Yachong Liao, Zhibin Mo, Jie Zhang, Qiaofeng Zhang, Bixiang Zhang, Lei
Published in
Biomarker Research
YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemn...
Ju, Chenxi He, Jing Wang, Chang Sheng, Jinxiu Jia, Jinlin Du, Dan Li, Hongle Zhou, Mingxia He, Fucheng
Published in
Biomarker Research
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive gastrointestinal cancers with high incidence and mortality. Therefore, it is necessary to identify novel sensitive and specific biomarkers for ESCC detection and treatment. Circular RNAs (circRNAs) are a type of noncoding RNAs featured by their covalently closed circular struct...
Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam
Published in
Biomarker Research
Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigeneti...
Villalona-Calero, Miguel A. Diaz, John P. Duan, Wenrui Diaz, Zuanel Schroeder, Eric D. Aparo, Santiago Gatcliffe, Troy Albrecht, Federico Venkatappa, Siddhartha Guardiola, Victor
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Published in
Biomarker Research
Background Given the observed antitumor activity of immune-checkpoint-inhibitors in patients with mismatch-repair deficient (MSI-H) tumors, we hypothesized that deficiency in homologous-recombination-repair (HRR) can also influence susceptibility. Methods Patients with disease progression on standard of care and for whom pembrolizumab had no FDA ap...
Liu, Jinyan Zhang, Yi
Published in
Biomarker Research
Cancer is a complicated disease attributed to multifactorial changes, which causes difficulties with treatment strategies. Various factors have been regarded as the main contributors, and infectious etiological factors have recently attracted interest. Several microbiomes contribute to carcinogenesis, cancer progression, and modulating cancer treat...
Cao, Weijie Xing, Haizhou Li, Yingmei Tian, Wenliang Song, Yongping Jiang, Zhongxing Yu, Jifeng
Published in
Biomarker Research
The claudin18.2 (CLDN18.2) protein, an isoform of claudin18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cance...
Ruiz, M. González, S. Bonnet, C. Deng, S. X.
Published in
Biomarker Research
Background Dysfunction or loss of limbal stem cells can result in limbal stem cell deficiency (LSCD), a disease that cause corneal opacity, pain, and loss of vision. Cultivated limbal epithelial transplantation (CLET) can be used to restore stem cell niche homeostasis and replenish the progenitor pool. Transplantation has been reported with high su...
Marañón, Patricia Fernández-García, Carlos Ernesto Isaza, Stephania C. Rey, Esther Gallego-Durán, Rocío Montero-Vallejo, Rocío de Cía, Javier Rodríguez Ampuero, Javier Romero-Gómez, Manuel García-Monzón, Carmelo
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Published in
Biomarker Research
Background Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide, being non-alcoholic steatohepatitis (NASH) its most clinically relevant form. Given the risks associated with taking a liver biopsy, the design of accurate non-invasive methods to identify NASH patients is of upmost importance. BMP2 plays...
