Jeong, Soyeon Lee, Hyeokjun Jeong, Yeonsu Cha, Hyung Joon
Published in
Biomacromolecules
Conventional anticancer therapies, including surgical resection, radiation, and chemotherapy, are the primary modalities for treating various forms of cancer. However, these treatments often bring significant side effects and risk of recurrence, underscoring the need for more targeted and less invasive therapeutic options. To address this challenge...
Wang, Yu Liao, Yusi Zhang, Ying-Jin Wu, Xiu-Hai Qiao, Zeng-Ying Wang, Hao
Published in
Biomacromolecules
Peptide materials, such as self-assembled peptide materials, are very important biomaterials. Driven by multiple interaction forces, peptide molecules can self-assemble into a variety of different macroscopic forms with different properties and functions. In recent years, the research on self-assembled peptides has made great progress from laborato...
Pascouau, Chloé Schweitzer, Maren Besenius, Pol
Published in
Biomacromolecules
Peptide-polymer conjugates (PPCs) are of particular interest in the development of responsive, adaptive, and interactive materials due to the benefits offered by combining both building blocks and components. This review presents pioneering work as well as recent advances in the design of peptide-polymer conjugates, with a specific focus on their t...
Sun, Bingbing Yang, Haowen Li, Yudong Scheerstra, Jari F van Stevendaal, Marleen H M E Li, Shukun van Hest, Jan C M
Published in
Biomacromolecules
Photodynamic therapy (PDT) has demonstrated efficacy in eliminating local tumors, yet its effectiveness against metastasis is constrained. While immunotherapy has exhibited promise in a clinical context, its capacity to elicit significant systemic antitumor responses across diverse cancers is often limited by the insufficient activation of the host...
Viola, Martina Ainsworth, Madison J Mihajlovic, Marko Cedillo-Servin, Gerardo van Steenbergen, Mies J van Rijen, Mattie de Ruijter, Mylène Castilho, Miguel Malda, Jos Vermonden, Tina
...
Published in
Biomacromolecules
Hydrogels are ideal materials to encapsulate cells, making them suitable for applications in tissue engineering and regenerative medicine. However, they generally do not possess adequate mechanical strength to functionally replace human tissues, and therefore they often need to be combined with reinforcing structures. While the interaction at the i...
Jäger, Eliézer Ilina, Olga Dölen, Yusuf Valente, Michael van Dinther, Eric A W Jäger, Alessandro Figdor, Carl G Verdoes, Martijn
Published in
Biomacromolecules
The antitumor immunity can be enhanced through the synchronized codelivery of antigens and immunostimulatory adjuvants to antigen-presenting cells, particularly dendritic cells (DCs), using nanovaccines (NVs). To study the influence of intracellular vaccine cargo release kinetics on the T cell activating capacities of DCs, we compared stimuli-respo...
Shatabayeva, Elvira O Kaldybekov, Daulet B Ulmanova, Leila Zhaisanbayeva, Balnur A Mun, Ellina A Kenessova, Zarina A Kudaibergenov, Sarkyt E Khutoryanskiy, Vitaliy V
Published in
Biomacromolecules
Gelatin is a water-soluble natural polyampholyte with poor mucoadhesive properties. It has traditionally been used as a major ingredient in many pharmaceuticals, including soft and hard capsules, suppositories, tissue engineering, and regenerative medicine. The mucoadhesive properties of gelatin can be improved by modifying it through conjugation w...
Fang, Yuekun Hu, Jie Zou, Yang Wang, Zhichen Ye, Yuchen Zhang, Changchun
Published in
Biomacromolecules
Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by the oxidative microenvironment. Herein, bone marrow mesenchymal stem cell ...
Li, Qifen Wang, Leixiang Yu, Lu Li, Chengbo Xie, Xianrui Yan, Huanhuan Zhou, Wenjuan Wang, Chunhua Liu, Zhonghao Hou, Guige
...
Published in
Biomacromolecules
In recent years, the utilization of medical devices has gradually increased and implantation procedures have become common treatments. However, patients are susceptible to the risk of implant infections. This study utilized chemical grafting to immobilize polyethylenimine (QPEI) and hyaluronic acid (HA) on the surface of the mesh to improve biocomp...
Flood, Ronan J Cerofolini, Linda Fragai, Marco Crowley, Peter B
Published in
Biomacromolecules
We describe complex formation between a designed pentameric β-propeller and the anionic macrocycle sulfonato-calix[8]arene (sclx8), as characterized by X-ray crystallography and NMR spectroscopy. Two crystal structures and 15N HSQC experiments reveal a single calixarene binding site in the concave pocket of the β-propeller toroid. Despite the symme...
