El-Hakim, Yumna Mani, Kathiresh Kumar Eldouh, Amir Pandey, Sivani Grimaldo, Maria T. Dabney, Alan Pilla, Rachel Sohrabji, Farida
Published in
Biology of Sex Differences
BackgroundSex differences in experimental stroke outcomes are well documented, such that adult males have a greater infarct volume, increased stroke-induced mortality, and more severe sensory-motor impairment. Based on recent evidence that the gut is an early responder to stroke, the present study tested the hypothesis that sex differences in strok...
Muilwijk, Mirthe Callender, Nardie Goorden, Susan Vaz, Frédéric M. van Valkengoed, Irene G. M.
Published in
Biology of Sex Differences
BackgroundMen have a higher risk for cardiovascular disease (CVD) early in life, while women have a higher risk later in life. The sex-related differences in CVD risk, especially by age, could be related to sphingolipid metabolism. We compared plasma sphingolipid concentrations and its increase by age in men and women.MethodsPlasma concentrations o...
Dupuis, Maria Luisa Pagano, Maria Teresa Pierdominici, Marina Ortona, Elena
Published in
Biology of Sex Differences
Over the last decades, a central role for vitamin D in immune modulation has been well established. The active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with vitamin D receptor, exerts different activities on the innate and adaptive immune system, among which suppression of inflammation and promotion of tolerogenic r...
Philbois, Stella V. Facioli, Tábata P. Gastaldi, Ada C. Rodrigues, Jhennyfer A. L. Tank, Jens Fares, Thauane H. Rodrigues, Karine P. Souza, Hugo C. D.
Published in
Biology of Sex Differences
BackgroundNormotensive premenopausal women show a vagal predominance of cardiac autonomic modulation, whereas age-matched men show a predominance of sympathetic modulation. However, some women develop systemic arterial hypertension (SAH) even with preserved ovarian function. Our hypothesis is that these women may have cardiovascular autonomic param...
Jašarević, Eldin Hecht, Patrick M. Fritsche, Kevin L. Geary, David C. Rivera, Rocío M. Beversdorf, David Q.
Published in
Biology of Sex Differences
Early life adversity is widely recognized as a key risk factor for early developmental perturbations and contributes to the presentation of neuropsychiatric disorders in adulthood. Neurodevelopmental disorders exhibit a strong sex bias in susceptibility, presentation, onset, and severity, although the underlying mechanisms conferring vulnerability ...
Gong, Xuhe Zhou, Li Ding, Xiaosong Li, Hongwei Chen, Hui
Published in
Biology of Sex Differences
BackgroundDifferences in outcomes for women and men after percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) patients remain controversial. Herein, we compared the clinical outcomes by sex in CTO patients undergoing PCI.MethodsA total of 563 consecutive patients (19% women) who were diagnosed with CTO at a single center in Ch...
Manwani, Bharti Fall, Pamela Zhu, Liang O’Reilly, Meaghan Roy Conway, Sarah Staff, Ilene McCullough, Louise D.
Published in
Biology of Sex Differences
BackgroundSex differences in stroke have been attributed to the neuroprotective effects of estrogen, yet most clinical trials of estrogen supplementation for stroke prevention have failed. The contribution of sex hormones to stroke outcome remains a subject of debate. Aromatization of testosterone to estradiol in neural tissue leads to sexual diffe...
Cattaneo, Maria Grazia Banfi, Cristina Brioschi, Maura Lattuada, Donatella Vicentini, Lucia M.
Published in
Biology of Sex Differences
BackgroundCellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with predictable sex differences is studied. In this perspective, proteomics, and “omics” approaches in general, can provide powerful tools to obtain comprehensive cellular maps, thus favoring the discovery of s...
Cunningham, Mark W. Jr Amaral, Lorena M. Campbell, Nathan E. Cornelius, Denise C. Ibrahim, Tarek Vaka, Venkata Ramana LaMarca, Babbette
Published in
Biology of Sex Differences
Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Moreover, RUPP and PE women have elevated vasoconstrictor peptide endothelin-1 (ET-1) and inflammation. Interleukin-2 (IL-2) is a cytokine that...
Mills, Lauren J. Spector, Logan G. Largaespada, David A. Williams, Lindsay A.
Published in
Biology of Sex Differences
BackgroundMales
