Luger, Tessy Seibt, Robert Rieger, Monika A. Steinhilber, Benjamin
Published in
Biology of Sex Differences
BackgroundMusculoskeletal disorders are more prevalent among women than among men, which may be explained by aspects of motor control, including neuromuscular requirements and motor variability. Using an exploratory approach, this study aimed to evaluate sex differences in neuromuscular responses and motor variability during a repetitive task perfo...
Peng, Chao Xu, Xinbo Li, Yanshu Li, Xueyang Yang, Xiaoyu Chen, Hongyan Zhu, Yin Lu, Nonghua He, Cong
Published in
Biology of Sex Differences
BackgroundAccumulating evidence indicates that high-fat diet (HFD)-induced metabolic disorders are associated with dysbiosis of the gut microbiota. However, the sex-specific characteristics of the gut microbiota and its association with a sexually dimorphic response to a HFD remain unclear.MethodsMale and female mice were randomly assigned to recei...
Pingili, Ajeeth K. Jennings, Brett L. Mukherjee, Kamalika Akroush, Wadah Gonzalez, Frank J. Malik, Kafait U.
Published in
Biology of Sex Differences
BackgroundPreviously, we showed that 6β-hydroxytestosterone (6β-OHT), a cytochrome P450 1B1 (CYP1B1)-derived metabolite of testosterone, contributes to angiotensin II (Ang II)-induced hypertension in male mice. This study was conducted to test the hypothesis that 6β-OHT contributes to increased vascular reactivity, endothelial dysfunction, vascular...
Meester, Irene Manilla-Muñoz, Edgar León-Cachón, Rafael B. R. Paniagua-Frausto, Gustavo A. Carrión-Alvarez, Diego Ruiz-Rodríguez, C. Orelli Rodríguez-Rangel, Ximena García-Martínez, Joyce M.
Published in
Biology of Sex Differences
BackgroundSex bias in immune function has been contributed in part to a preponderance of immune system-related genes (ISRG) on the X-chromosome. We verified whether ISRG are more abundant on the X chromosome as compared to autosomal chromosomes and reflected on the impact of our findings.MethodsConsulting freely accessible databases, we performed a...
Zhang, Wenxin Wu, Hui Xu, Qi Chen, Sheng Sun, Lihong Jiao, Cuicui Wang, Luyang Fu, Feng Feng, Ying Qian, Xiaowei
...
Published in
Biology of Sex Differences
Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack of consensus to regard estrogen as a variable when working with animal models; thus, the influence of hormones’ fluctuations on nociception has continually been neglec...
de Ritter, Rianneke de Jong, Marit Vos, Rimke C. van der Kallen, Carla J. H. Sep, Simone J. S. Woodward, Mark Stehouwer, Coen D. A. Bots, Michiel L. Peters, Sanne A. E.
Published in
Biology of Sex Differences
Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the relative risk of vascular disease associated with diabetes is substantially higher in women than men. The mechanisms that explain the sex difference have not been identified. However, this excess risk could be due to certain underlying biological difference...
Henricks, Angela M. Sullivan, Emily D. K. Dwiel, Lucas L. Keus, Karina M. Adner, Ethan D. Green, Alan I. Doucette, Wilder T.
Published in
Biology of Sex Differences
BackgroundAlthough male and female rats differ in their patterns of alcohol use, little is known regarding the neural circuit activity that underlies these differences in behavior. The current study used a machine learning approach to characterize sex differences in local field potential (LFP) oscillations that may relate to sex differences in alco...
Maxeiner, Stephan Sester, Martina Krasteva-Christ, Gabriela
Published in
Biology of Sex Differences
BackgroundSince the early days of PCR techniques, sex identification, “sex-typing,” of genomic DNA samples has been a fundamental part of human forensic analysis but also in animal genetics aiming at strategic livestock breeding. Most analyses are employing the AMELX/AMELY gene loci on the X and Y chromosomes present in most mammals. We hypothesize...
Che, Chen Dudick, Kayla Shoemaker, Robin
Published in
Biology of Sex Differences
BackgroundOver a third of reproductive-age women in the USA are obese, and the prevalence of cardiovascular disease (CVD) is rising in premenopausal women. Cardiac hypertrophy is an independent predictor of CVD. In contrast to pregnancy, where transiently increased left ventricular (LV) mass is not associated with cardiac damage, obesity-mediated c...
Ramírez Sepúlveda, Jorge I. Bolin, Karin Mofors, Johannes Leonard, Dag Svenungsson, Elisabet Jönsen, Andreas Bengtsson, Christine Zickert, Agneta Björk, Albin Bengtsson, Anders A.
...
Published in
Biology of Sex Differences
ObjectiveSystemic lupus erythematosus (SLE) predominantly affects women, but previous studies suggest that men with SLE present a more severe disease phenotype. In this study, we investigated a large and well-characterized patient group with the aim of identifying sex differences in disease manifestations, with a special focus on renal involvement....
