Published in Biology Open
Summary: Spermatogonial stem cell transplantation in mice with germline ablation by genetic modification of a specific gene.
Published in Biology Open
Summary: Knockout of Ctdp1 reveals its essential role in mammalian embryogenesis and regulation of the cell cycle.
Published in Biology Open
Summary: We report a novel sh3pxd2b mutant zebrafish model that develops cutaneous and musculoskeletal fibrosis, similar to that observed in people with Frank-Ter Haar syndrome.
Published in Biology open
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase C (PKC) agonists (e.g. ingenol A) or histone deace...
Published in Biology Open
Summary: Our findings provided a new role of miR-9-5p/PPAR in the occurrence and development of HS fibroblasts, promising a new target for HS.
Published in Biology Open
Summary: Our study identifies the role of parasite chorismate synthase and salicylic acid on host immunopathology and disease manifestation in cerebral malaria and points towards a pathway associated with salicylic acid-mediated autophagy of the malaria parasite.
Published in Biology Open
Summary: Under physiological conditions, CD47 differentially regulates white fat and brown fat function. Through a coordinated manner, altered fuel availability via white adipose tissue lipolysis may influence brown adipose tissue energy expenditure and then body weight management.
Published in Biology Open
Summary: We describe the development and validation of a hepatocyte differentiation protocol using iPSCs from a panel of NASH donors and healthy controls.
Published in Biology Open
Summary: Neuronal expression of an ALS-associated mutation in a DNA/RNA-binding protein disrupts the organization and function of the C. elegans neuromuscular junction.
Published in Biology Open
Summary: For spiders, the bouncing gait and the hydraulic system contribute to the lower transport cost at low speed, while the hydraulic system greatly increases the transport cost at high speed.
