Zhang, Xianyu Zhao, Xin Li, Guoling Zhang, Mao Xing, Pingping Li, Zicong Chen, Bin Yang, Huaqiang Wu, Zhenfang
Published in
Biology Open
Summary: Spermatogonial stem cell transplantation in mice with germline ablation by genetic modification of a specific gene.
Qiao, Fangfang Law, Henry C.-H. Krieger, Kimiko L. Clement, Emalie J. Xiao, Yi Buckley, Shannon M. Woods, Nicholas T.
Published in
Biology Open
Summary: Knockout of Ctdp1 reveals its essential role in mammalian embryogenesis and regulation of the cell cycle.
de Vos, Ivo J. H. M. Wong, Arnette Shi Wei Taslim, Jason Ong, Sheena Li Ming Syder, Nicole C. Goggi, Julian L. Carney, Thomas J. van Steensel, Maurice A. M.
Published in
Biology Open
Summary: We report a novel sh3pxd2b mutant zebrafish model that develops cutaneous and musculoskeletal fibrosis, similar to that observed in people with Frank-Ter Haar syndrome.
Taylor, Jared P Armitage, Lucas H Aldridge, Daniel L Cash, Melanie N Wallet, Mark A
Published in
Biology open
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase C (PKC) agonists (e.g. ingenol A) or histone deace...
Chai, Chi-Yung Tai, I.-Chun Zhou, Rui Song, Junlong Zhang, Chaoying Sun, Shengrong
Published in
Biology Open
Summary: Our findings provided a new role of miR-9-5p/PPAR in the occurrence and development of HS fibroblasts, promising a new target for HS.
Chakrabarti, Malabika Kannan, Deepika Munjal, Akshay Choudhary, Hadi Hasan Mishra, Satish Singh, Shailja
Published in
Biology Open
Summary: Our study identifies the role of parasite chorismate synthase and salicylic acid on host immunopathology and disease manifestation in cerebral malaria and points towards a pathway associated with salicylic acid-mediated autophagy of the malaria parasite.
Norman-Burgdolf, Heather Li, Dong Sullivan, Patrick Wang, Shuxia
Published in
Biology Open
Summary: Under physiological conditions, CD47 differentially regulates white fat and brown fat function. Through a coordinated manner, altered fuel availability via white adipose tissue lipolysis may influence brown adipose tissue energy expenditure and then body weight management.
Gurevich, Igor Burton, Sarah A. Munn, Christie Ohshima, Makiko Goedland, Madelyn E. Czysz, Katherine Rajesh, Deepika
Published in
Biology Open
Summary: We describe the development and validation of a hepatocyte differentiation protocol using iPSCs from a panel of NASH donors and healthy controls.
Markert, Sebastian M. Skoruppa, Michael Yu, Bin Mulcahy, Ben Zhen, Mei Gao, Shangbang Sendtner, Michael Stigloher, Christian
Published in
Biology Open
Summary: Neuronal expression of an ALS-associated mutation in a DNA/RNA-binding protein disrupts the organization and function of the C. elegans neuromuscular junction.
Hao, Xin Ma, Wenxing Liu, Chunbao Qian, Zhihui Ren, Luquan Ren, Lei
Published in
Biology Open
Summary: For spiders, the bouncing gait and the hydraulic system contribute to the lower transport cost at low speed, while the hydraulic system greatly increases the transport cost at high speed.