Bateman, Andrew
Published in
Biology Direct
AbstractTwo apparently irreconcilable models dominate research into the origin of eukaryotes. In one model, amitochondrial proto-eukaryotes emerged autogenously from the last universal common ancestor of all cells. Proto-eukaryotes subsequently acquired mitochondrial progenitors by the phagocytic capture of bacteria. In the second model, two prokar...
Lisitsyna, Olga M. Kurnaeva, Margarita A. Arifulin, Eugene A. Shubina, Maria Y. Musinova, Yana R. Mironov, Andrey A. Sheval, Eugene V.
Published in
Biology Direct
BackgroundThe origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one of the most important events in the evolution of eukaryotic cells. How proteins were selected for import into the forming nucleus r...
Mencía, Mario
Published in
Biology Direct
AbstractThe archaea-bacteria lipid divide is one of the big evolutionary enigmas concerning these two domains of life. In short, bacterial membranes are made of fatty-acid esters whereas archaeal ones contain isoprenoid ethers, though at present we do not have a good understanding on why they evolved differently. The lateral proton transfer mode of...
Lennon, Jay T. Locey, Kenneth J.
Published in
Biology Direct
AbstractUntil recently, our planet was thought to be home to ~ 107 species, largely belonging to plants and animals. Despite being the most abundant organisms on Earth, the contribution of microbial life to global biodiversity has been greatly underestimated and, in some cases, completely overlooked. Using a compilation of data known as the Global ...
Jin, Yuan Zhou, Jianglin Zhou, Jing Hu, Mingda Zhang, Qi Kong, Na Ren, Hongguang Liang, Long Yue, Junjie
Published in
Biology Direct
BackgroundAccurate classification of different Burkholderia cepacia complex (BCC) species is essential for therapy, prognosis assessment and research. The taxonomic status of BCC remains problematic and an improved knowledge about the classification of BCC is in particular needed.MethodsWe compared phylogenetic trees of BCC based on 16S rRNA, recA,...
Chierici, Marco Francescatto, Margherita Bussola, Nicole Jurman, Giuseppe Furlanello, Cesare
Published in
Biology Direct
BackgroundDrug-induced liver injury (DILI) is a major concern in drug development, as hepatotoxicity may not be apparent at early stages but can lead to life threatening consequences. The ability to predict DILI from in vitro data would be a crucial advantage. In 2018, the Critical Assessment Massive Data Analysis group proposed the CMap Drug Safet...
Omari, Mohamed Lange, Alexander Plöntzke, Julia Röblitz, Susanna
Published in
Biology Direct
BackgroundNutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of anovulation have been observed, resulting from alterations in luteinizing hormone concent...
Sumsion, G. Rex Bradshaw, Michael S. III Beales, Jeremy T. Ford, Emi Caryotakis, Griffin R. G. Garrett, Daniel J. LeBaron, Emily D. Nwosu, Ifeanyichukwu O. Piccolo, Stephen R.
Published in
Biology Direct
BackgroundDrug-induced liver injury (DILI) is a serious concern during drug development and the treatment of human disease. The ability to accurately predict DILI risk could yield significant improvements in drug attrition rates during drug development, in drug withdrawal rates, and in treatment outcomes. In this paper, we outline our approach to p...
Caputo, Aurélia Fournier, Pierre-Edouard Raoult, Didier
Published in
Biology Direct
BackgroundIn the recent years, genomic and pan-genomic studies have become increasingly important. Culturomics allows to study human microbiota through the use of different culture conditions, coupled with a method of rapid identification by MALDI-TOF, or 16S rRNA. Bacterial taxonomy is undergoing many changes as a consequence. With the help of pan...
DeLisi, Charles
Published in
Biology Direct
After publication of this article [1], the author brought to our attention that there are some errors in the article.
