Liu, Jin Chen, Lang Chang, Hyesang Rudoler, Jeremy Al-Zughoul, Ahmad Belal Kang, Julia Boram Abrams, Daniel A Menon, Vinod
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Memory impairments have profound implications for social communication and educational outcomes in children with autism spectrum disorder (ASD). However, the precise nature of memory dysfunction in children with ASD and the underlying neural circuit mechanisms remain poorly understood. The default mode network (DMN) is a brain network that is assoc...
Liloia, Donato Cauda, Franco Uddin, Lucina Q Manuello, Jordi Mancuso, Lorenzo Keller, Roberto Nani, Andrea Costa, Tommaso
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Although neuroimaging research has identified atypical neuroanatomical substrates in individuals with autism spectrum disorder (ASD), it is at present unclear whether and to what extent disorder-selective gray matter alterations occur in this spectrum of conditions. In fact, a growing body of evidence shows a substantial overlap between the pathomo...
de Cates, Angharad N Martens, Marieke A G Wright, Lucy C Gibson, Daisy Spitz, Gershon Gould van Praag, Cassandra D Suri, Sana Cowen, Philip J Murphy, Susannah E Harmer, Catherine J
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Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Cognitive deficits are often comorbid with mood disorders and can cause significant functional impairment even after resolution of the primary mood symptoms. We do not currently have pharmacological treatments that adequately address these deficits. 5-HT4 receptor agonists show promise as potential procognitive agents in animal and early human tran...
Fuelscher, Ian Hyde, Christian Thomson, Phoebe Vijayakumar, Nandita Sciberras, Emma Efron, Daryl Anderson, Vicki Hazell, Philip Silk, Timothy J
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Few longitudinal studies have investigated whether white matter development reflects differential outcomes for children with and without attention-deficit/hyperactivity disorder (ADHD). To examine whether deviations from typical trajectories of white matter development were associated with the persistence or remission of ADHD symptoms, this study e...
Jurgiel, Joseph Miyakoshi, Makoto Dillon, Andrea Piacentini, John Loo, Sandra K
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Attention-deficit/hyperactivity disorder (ADHD) and persistent tic disorder (PTD) are two neurodevelopmental disorders that frequently co-occur. Contributions of each disorder to cognitive and behavioral deficits have been reported. In this paper, we tested 3 models of pathophysiology for the two disorders (additive, interactive, and phenotypic) us...
Mei, Ting Forde, Natalie J Floris, Dorothea L Dell'Acqua, Flavio Stones, Richard Ilioska, Iva Durston, Sarah Moessnang, Carolin Banaschewski, Tobias Holt, Rosemary J
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Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Although many studies have explored atypicalities in gray matter (GM) and white matter (WM) morphology of autism, most of them relied on unimodal analyses that did not benefit from the likelihood that different imaging modalities may reflect common neurobiology. We aimed to establish brain patterns of modalities that differentiate between individua...
Broekhuizen, Aniek Vriend, Chris Wolf, Nadja Koenen, Emma H van Oppen, Patricia van Balkom, Anton J L M Visser, Henny A D van den Heuvel, Odile A
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Poor insight in obsessive-compulsive disorder (OCD) is associated with higher symptom severity, more comorbidities, and worse response to treatment. This study aimed to elucidate underlying mechanisms of poor insight in OCD by exploring its neurobiological correlates. Using a symptom provocation task during functional magnetic resonance imaging, we...
Fradkin, Isaac Nour, Matthew M Dolan, Raymond J
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Natural language processing (NLP) holds promise to transform psychiatric research and practice. A pertinent example is the success of NLP in the automatic detection of speech disorganization in formal thought disorder (FTD). However, we lack an understanding of precisely what common NLP metrics measure and how they relate to theoretical accounts of...
Saperia, Sarah Felsky, Daniel Da Silva, Susana Siddiqui, Ishraq Rector, Neil Remington, Gary Zakzanis, Konstantine K Foussias, George
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
A critical facet of motivation is effort-based decision making, which refers to the mental processes involved in deciding whether a potential reward is worth the effort. To advance understanding of how individuals with schizophrenia and major depressive disorder utilize cost-benefit information to guide choice behavior, this study aimed to characte...
Bagonis, Maria Cornea, Emil Girault, Jessica B Stephens, Rebecca L Kim, SunHyung Prieto, Juan Carlos Styner, Martin Gilmore, John H
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
The white matter (WM) connectome is important for cognitive development and intelligence and is altered in neuropsychiatric illnesses. Little is known about how the WM connectome develops or its relationship to IQ in early childhood. The development of node centrality in the WM connectome was studied in a longitudinal cohort of 226 (123 female) chi...
