Iraji, Armin Chen, Jiayu Lewis, Noah Faghiri, Ashkan Fu, Zening Agcaoglu, Oktay Kochunov, Peter Adhikari, Bhim M Mathalon, Daniel H Pearlson, Godfrey D
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Published in
Biological psychiatry
Schizophrenia research reveals sex differences in incidence, symptoms, genetic risk factors, and brain function. However, a knowledge gap remains regarding sex-specific schizophrenia alterations in brain function. Schizophrenia is considered a dysconnectivity syndrome, but the dynamic integration and segregation of brain networks are poorly underst...
Jefsen, Oskar Hougaard Holde, Katrine McGrath, John J Rajagopal, Veera Manikandan Albiñana, Clara Vilhjálmsson, Bjarni Jóhann Grove, Jakob Agerbo, Esben Yilmaz, Zeynep Plana-Ripoll, Oleguer
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Published in
Biological psychiatry
Education is essential for socioeconomic security and long-term mental health; however, mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap. We unrav...
Mariano, Marika Rossetti, Ileana Maravita, Angelo Paulesu, Eraldo Zapparoli, Laura
Published in
Biological psychiatry
Sensory attenuation (SA), the dampened perception of self-generated sensory information, is typically associated with reduced event-related potential signals, such as for the N1 component of auditory event-related potentials. SA, together with efficient monitoring of intentions and actions, should facilitate the distinction between self-generated a...
Dogra, Shalini Aguayo, Caleb Xiang, Zixiu Putnam, Jason Smith, Joshua Johnston, Curran Foster, Daniel J Lindsley, Craig W Niswender, Colleen M Conn, P Jeffrey
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Published in
Biological psychiatry
Polymorphisms in the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are associated with an increased likelihood of schizophrenia diagnosis and can predict improvements in negative symptoms following treatment with antipsychotics. However, the mechanisms by which mGlu3 can regulate brain circuits involved in schizophrenia pathophysiolog...
Meyer, Garance M Hollunder, Barbara Li, Ningfei Butenko, Konstantin Dembek, Till A Hart, Lauren Nombela, Cristina Mosley, Philip Akram, Harith Acevedo, Nicola
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Published in
Biological psychiatry
Deep brain stimulation (DBS) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Several stimulation targets have been used, mostly in and around the anterior limb of the internal capsule and ventral striatum. However, the precise target within this region remains a matter of debate. Here, we retrospectivel...
Tsetsos, Fotis Topaloudi, Apostolia Jain, Pritesh Yang, Zhiyu Yu, Dongmei Kolovos, Petros Tumer, Zeynep Rizzo, Renata Hartmann, Andreas Depienne, Christel
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Published in
Biological psychiatry
Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture and is characterized by multiple motor tics and at least one vocal tic persisting for more than 1 year. We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6133 indi...
Gadot, Ron Li, Ningfei Shofty, Ben Avendano-Ortega, Michelle McKay, Sarah Bijanki, Kelly R Robinson, Meghan E Banks, Garrett Provenza, Nicole Storch, Eric A
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Published in
Biological psychiatry
Deep brain stimulation (DBS) is an established and expanding therapy for treatment-refractory obsessive-compulsive disorder. Previous work has suggested that a white matter circuit providing hyperdirect input from the dorsal cingulate and ventrolateral prefrontal regions to the subthalamic nucleus could be an effective neuromodulatory target. We te...
Durand-de Cuttoli, Romain Martínez-Rivera, Freddyson J Li, Long Minier-Toribio, Angélica Dong, Zhe Cai, Denise J Russo, Scott J Nestler, Eric J Sweis, Brian M
Published in
Biological psychiatry
Economic stress can serve as a second hit for people who have already accumulated a history of adverse life experiences. How one recovers from a setback is a core feature of resilience but is seldom captured in animal studies. We challenged mice in a novel 2-hit stress model by first exposing them to chronic social defeat stress and then testing ad...
Zeng, Lu Fujita, Masashi Gao, Zongmei White, Charles C Green, Gilad S Habib, Naomi Menon, Vilas Bennett, David A Boyle, Patricia Klein, Hans-Ulrich
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Published in
Biological psychiatry
Depression, a common psychiatric illness and global public health problem, remains poorly understood across different life stages, which hampers the development of novel treatments. To identify new candidate genes for therapeutic development, we performed differential gene expression analysis of single-nucleus RNA sequencing data from the dorsolate...
Miller, Adam Bryant Jenness, Jessica L Elton, Amanda L Pelletier-Baldelli, Andrea Patel, Kinjal Bonar, Adrienne Martin, Sophia Dichter, Gabriel Giletta, Matteo Slavich, George M
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Published in
Biological psychiatry
Suicidal thoughts and behaviors (STBs) are common among adolescent girls and increase risk for suicide death. Emotion regulation difficulties are linked with STBs, particularly in response to targeted social rejection. However, neural correlates of this link have not been investigated and may identify novel targets for interventions. Here, we exami...
