Sharma, Nupur Osman, Christof
Published in
Biological Chemistry
The mitochondrial respiratory chain is composed of nuclear as well as mitochondrial-encoded subunits. A variety of factors mediate co-translational integration of mtDNA-encoded proteins into the inner membrane. In Saccharomyces cerevisiae, Mdm38 and Mba1 are ribosome acceptors that recruit the mitochondrial ribosome to the inner membrane, where the...
Olzog, V. Janett Freist, Lena I. Goldmann, Robin Fallmann, Jörg Weinberg, Christina E.
Published in
Biological Chemistry
Self-cleaving ribozymes are catalytic RNAs and can be found in all domains of life. They catalyze a site-specific cleavage that results in a 5′ fragment with a 2′,3′ cyclic phosphate (2′,3′ cP) and a 3′ fragment with a 5′ hydroxyl (5′ OH) end. Recently, several strategies to enrich self-cleaving ribozymes by targeted biochemical methods have been i...
Reiner, Andreas Kühl, Inge
Published in
Biological Chemistry
Gül, Désirée Habtemichael, Negusse Dietrich, Dimo Dietrich, Jörn Gößwein, Dorothee Khamis, Aya Deuss, Eric Künzel, Julian Schneider, Günter Strieth, Sebastian
...
Published in
Biological Chemistry
To improve management of head and neck squamous cell carcinoma patients, we need to increase our understanding of carcinogenesis, to identify biomarkers, and drug targets. This study aimed to identify novel biomarkers by providing transcriptomics profiles of matched primary tumors, lymph node metastasis, and non-malignant tissue of 20 HNSCC patient...
Behrendt, Marc
Published in
Biological Chemistry
The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3’s best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression p...
Lassak, Jürgen Sieber, Alina Hellwig, Michael
Published in
Biological Chemistry
Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantage...
Korn, Sophie Marianne Schlundt, Andreas
Published in
Biological Chemistry
The DNA-binding AT-rich interactive domain (ARID) exists in a wide range of proteins throughout eukaryotic kingdoms. ARID domain-containing proteins are involved in manifold biological processes, such as transcriptional regulation, cell cycle control and chromatin remodeling. Their individual domain composition allows for a sub-classification withi...
Li, Qing Wang, Wei Yang, Tao Li, Dongsheng Huang, Yinpeng Bai, Guang Li, Qiang
Published in
Biological Chemistry
Hepatocellular carcinoma (HCC) is one of the most common human cancers. Long non-coding RNA (lncRNA) has been demonstrated to play an important role in regulating tumor development. The current study aims to explore the specific role of LINC00520 during HCC progression. The present study identified that LINC00520 was upregulated in HCC tissues and ...
Fischer, Tobias F. Beck-Sickinger, Annette G.
Published in
Biological Chemistry
Chemerin is a small chemotactic protein and a key player in initiating the early immune response. As an adipokine, chemerin is also involved in energy homeostasis and the regulation of reproductive functions. Secreted as inactive prochemerin, it relies on proteolytic activation by serine proteases to exert biological activity. Chemerin binds to thr...
Xiao, Kai Peng, Gang
Published in
Biological Chemistry
Glioma is one of the most common primary intracranial carcinomas and typically associated with a dismal prognosis and poor quality of life. The identification of novel oncogenes is clinically valuable for early screening and prevention. Recently, the studies have revealed that long non-coding RNAs (lncRNAs) play important roles in the development a...
