D’Antoni, Simona de Bari, Lidia Valenti, Daniela Borro, Marina Bonaccorso, Carmela Maria Simmaco, Maurizio Vacca, Rosa Anna Catania, Maria Vincenza
Published in
Biological Chemistry
Impaired energy metabolism may play a role in the pathogenesis of neurodevelopmental disorders including fragile X syndrome (FXS). We checked brain energy status and some aspects of cell bioenergetics, namely the activity of key glycolytic enzymes, glycerol-3-phosphate shuttle and mitochondrial respiratory chain (MRC) complexes, in the cerebral cor...
Hassanlou, Maryam Soltani, Bahram M. Medlej, Abdallah Kay, Maryam Mowla, Seyed Javad
Published in
Biological Chemistry
MicroRNAs are small non-coding RNAs that are implicated in various biological processes. Hsa-miR-6165 (miR-6165), located in the p75NTR gene, is known to induce apoptosis in human cell lines, but its mechanism of action is not fully understood yet. Here, we predicted the insulin-like growth factor 1 receptor (IGF-1R) gene as a bona fide target for ...
Andrade, Sheila Siqueira de Sousa Faria, Alessandra Valéria de Paulo Queluz, Dagmar Ferreira-Halder, Carmen Veríssima
Published in
Biological Chemistry
Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the ‘natural factor...
Xu, Dejun Liu, Tianji He, Liu Han, Dongmei Ma, Ying Du, Jianshi
Published in
Biological Chemistry
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been identified as a regulatory molecule in angiogenesis. The goal of this study was to illustrate how MEG3 affects the angiogenesis of vascular endothelial cells. Expression of MEG3, miR-147 and intracellular cell adhesion molecule-1 (ICAM-1) in human microvascular endothelial cel...
Yamauchi, Kazuyoshi Kawakami, Yasushi
Published in
Biological Chemistry
Redox-mediated modulation of cysteine (Cys) thiols has roles in various pathophysiological functions. We recently found that formation of disulfide-linked complexes of apolipoprotein (apo) E3 prevented apoE3 from irreversible oxidation. In this report, the influence of modification of Cys thiols in apoE2 and apoE3 on interactions with lipids was in...
Basukala, Om Sarabia-Vega, Vanessa Banks, Lawrence
Published in
Biological Chemistry
Human papillomaviruses (HPVs) are major human carcinogens, causing around 5% of all human cancers, with cervical cancer being the most important. These tumors are all driven by the two HPV oncoproteins E6 and E7. Whilst their mechanisms of action are becoming increasingly clear through their abilities to target essential cellular tumor suppressor a...
Sarwar, Mohammad Tanvir Ohara-Nemoto, Yuko Kobayakawa, Takeshi Naito, Mariko Nemoto, Takayuki K.
Published in
Biological Chemistry
Prevotella intermedia, a Gram-negative anaerobic rod, is frequently observed in subgingival polymicrobial biofilms from adults with chronic periodontitis. Peptidases in periodontopathic bacteria are considered to function as etiological reagents. Prevotella intermedia OMA14 cells abundantly express an unidentified cysteine peptidase specific for Ar...
Kögler, Lisa Maria Stichel, Jan Beck-Sickinger, Annette G.
Published in
Biological Chemistry
G protein-coupled receptors (GPCRs) are of great pharmaceutical interest and about 35% of the commercial drugs target these proteins. Still there is huge potential left in finding molecules that target new GPCRs or that modulate GPCRs differentially. For a rational drug design, it is important to understand the structure, binding and activation of ...
Hill, Bradford G. Shiva, Sruti Ballinger, Scott Zhang, Jianhua Darley-Usmar, Victor M.
Published in
Biological Chemistry
It is now becoming clear that human metabolism is extremely plastic and varies substantially between healthy individuals. Understanding the biochemistry that underlies this physiology will enable personalized clinical interventions related to metabolism. Mitochondrial quality control and the detailed mechanisms of mitochondrial energy generation ar...
Aretz, Ina Jakubke, Christopher Osman, Christof
Published in
Biological Chemistry
Mitochondria supply virtually all eukaryotic cells with energy through ATP production by oxidative phosphoryplation (OXPHOS). Accordingly, maintenance of mitochondrial function is fundamentally important to sustain cellular health and various diseases have been linked to mitochondrial dysfunction. Biogenesis of OXPHOS complexes crucially depends on...
