Herrmann, Johannes M. Riemer, Jan
Published in
Biological Chemistry
The mitochondrial complex I serves as entry point for NADH into the electron transport chain. In animals, fungi and plants, additional NADH dehydrogenases carry out the same electron transfer reaction, however they do not pump protons. The apoptosis inducing factor (AIF, AIFM1 in humans) is a famous member of this group as it was the first pro-apop...
Herrmann, Johannes M. Becker, Katja Dick, Tobias P.
Published in
Biological Chemistry
Barbarino, Frederik Wäschenbach, Lucas Cavalho-Lemos, Virginia Dillenberger, Melissa Becker, Katja Gohlke, Holger Cortese-Krott, Miriam M.
Published in
Biological Chemistry
The mechanical properties of red blood cells (RBCs) are fundamental for their physiological role as gas transporters. RBC flexibility and elasticity allow them to survive the hemodynamic changes in the different regions of the vascular tree, to dynamically contribute to the flow thereby decreasing vascular resistance, and to deform during the passa...
Meyer, Andreas J. Dreyer, Anna Ugalde, José M. Feitosa-Araujo, Elias Dietz, Karl-Josef Schwarzländer, Markus
Published in
Biological Chemistry
Cys-based redox regulation was long regarded a major adjustment mechanism of photosynthesis and metabolism in plants, but in the recent years, its scope has broadened to most fundamental processes of plant life. Drivers of the recent surge in new insights into plant redox regulation have been the availability of the genome-scale information combine...
Linzner, Nico Loi, Vu Van Fritsch, Verena Nadin Antelmann, Haike
Published in
Biological Chemistry
Staphylococcus aureus is a major human pathogen, which encounters reactive oxygen, nitrogen, chlorine, electrophile and sulfur species (ROS, RNS, RCS, RES and RSS) by the host immune system, during cellular metabolism or antibiotics treatments. To defend against redox active species and antibiotics, S. aureus is equipped with redox sensing regulato...
Dehbashi, Moein Hojati, Zohreh Motovali-bashi, Majid Ganjalikhani-Hakemi, Mazdak Shimosaka, Akihiro Cho, William C.
Published in
Biological Chemistry
Cancer recurrence presents a huge challenge in cancer patient management. Immune escape is a key mechanism of cancer progression and metastatic dissemination. CD25 is expressed in regulatory T (Treg) cells including tumor-infiltrating Treg cells (TI-Tregs). These cells specially activate and reinforce immune escape mechanism of cancers. The suppres...
Erdbrügger, Pia Fröhlich, Florian
Published in
Biological Chemistry
Fatty acids (FAs) are a highly diverse class of molecules that can have variable chain length, number of double bonds and hydroxylation sites. FAs with 22 or more carbon atoms are described as very long chain fatty acids (VLCFAs). VLCFAs are synthesized in the endoplasmic reticulum (ER) through a four-step elongation cycle by membrane embedded enzy...
Brüne, Bernhard
Published in
Biological Chemistry
Lassak, Jürgen Schlundt, Andreas
Published in
Biological Chemistry
Kubíková, Jana Reinig, Rebecca Salgania, Harpreet Kaur Jeske, Mandy
Published in
Biological Chemistry
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesi...
