Denisov, Stepan S. Heinzmann, Alexandra C. A. Vajen, Tanja Vries, Mark H. M. Megens, Remco T. A. Suylen, Dennis Koenen, Rory R. Post, Mark J. Ippel, Johannes H. Hackeng, Tilman M.
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Published in
Bioconjugate Chemistry
Atherosclerosis is one of the leading causes of mortality in developed and developing countries. The onset of atherosclerosis development is accompanied by overexpression of several inflammatory chemokines. Neutralization of these chemokines by chemokine-binding agents attenuates atherosclerosis progression. Here, we studied structural binding feat...
Eid, Emad Boross, Gábor N. Sun, Hao Msallam, Muna Singh, Sumeet K. Brik, Ashraf
Published in
Bioconjugate Chemistry
Interferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like modifiers (ULM) family, which adopts a β-grasp fold domain(s) similar to ubiquitin (Ub) with only minor sequence homology. ISG15 consists of two Ub-like domains and aids the immune system in neutralizing infections by numerous pathogens and plays an important role in defending ...
Crone, Niek S. A. Kros, Alexander Boyle, Aimee L.
Published in
Bioconjugate Chemistry
Peptide stapling is a technique which has been widely employed to constrain the conformation of peptides. One of the effects of such a constraint can be to modulate the interaction of the peptide with a binding partner. Here, a cysteine bis-alkylation stapling technique was applied to generate structurally isomeric peptide variants of a heterodimer...
Chen, Ying-Chu Faver, John C. Ku, Angela F. Miklossy, Gabriella Riehle, Kevin Bohren, Kurt M. Ucisik, Melek N. Matzuk, Martin M. Yu, Zhifeng Simmons, Nicholas
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Published in
Bioconjugate Chemistry
DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C–N coupling is a valuable synthetic method for the construction of DECL chemical matter; however, currently disclosed methods have only been demonstr...
Wouters, Simone F. A. Vugs, Willem J. P. Arts, Remco de Leeuw, Nynke M. Teeuwen, Roy W. H. Merkx, Maarten
Published in
Bioconjugate Chemistry
Bioluminescent antibodies represent attractive detection agents in both bioanalytical assays and imaging. Currently, their preparation relies on genetic fusion of luciferases to antibodies or nonspecific chemical conjugation strategies. Here, we report a generic method to generate well-defined covalent antibody–luciferase conjugates starting from c...
Hensbergen, Albertus Wijnand van Willigen, Danny M. van Beurden, Florian van Leeuwen, Pim J. Buckle, Tessa Schottelius, Margret Maurer, Tobias Wester, Hans-Jürgen van Leeuwen, Fijs W. B.
Published in
Bioconjugate Chemistry
Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA–PET), it can also be used to guide ...
Pretto, Chiara van Hest, Jan C. M.
Published in
Bioconjugate Chemistry
Virus like particles obtained from the Cowpea Chlorotic Mottle Virus (CCMV) represent an innovative platform for drug delivery applications. Their unique reversible self-assembly properties as well as their suitability for both cargo loading and functionalization make them a versatile scaffold for numerous purposes. One of the main drawbacks of thi...
Du, Bujie Jiang, Xingya Huang, Yingyu Li, Siqing Lin, Jason C Yu, Mengxiao Zheng, Jie
Published in
Bioconjugate Chemistry
Subtle changes in size can induce distinct responses of the body to hard nanomaterials; however, it is largely unknown whether just a few ethylene oxide unit differences in soft poly(ethylene glycol) (PEG) molecules could significantly alter the renal clearance of small molecules. By systematically investigating in vivo transport of the representat...
Marqvorsen, Mikkel H. S. Araman, Can van Kasteren, Sander I.
Published in
Bioconjugate Chemistry
Glycosylation plays a myriad of roles in the immune system: Certain glycans can interact with specific immune receptors to kickstart a pro-inflammatory response, whereas other glycans can do precisely the opposite and ameliorate the immune response. Specific glycans and glycoforms can themselves become the targets of the adaptive immune system, lea...
Cremers, Glenn A. O. Rosier, Bas J. H. M. Riera Brillas, Roger Albertazzi, Lorenzo de Greef, Tom F. A.
Published in
Bioconjugate Chemistry
The combination of the specificity of antibodies and the programmability of DNA nanotechnology has provided the scientific community with a powerful tool to label and unambiguously distinguish a large number of subcellular targets using fluorescence-based read-out methods. Whereas primary antibodies are commercially available for a large class of t...
