Dos Santos, Patty K Altei, Wanessa F Danilucci, Taís M Lino, Rafael L B Pachane, Bianca C Nunes, Ana C C Selistre-de-Araujo, Heloisa S
Published in
Biochimie
Angiogenesis, a crucial process in tumor progression, is mainly regulated by vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown the interaction between α2β1 integrin, a collagen receptor, and VEGFR2 in VEGF-driven angiogenesis in vitro and in vivo. Alternagin-C (ALT-C), an ECD-disintegrin-like protein from Bothro...
Alifano, Marco Alifano, Pietro Forgez, Patricia Iannelli, Antonio
Published in
Biochimie
• Significant aspects of COVID-19 pandemic remain obscure. • Angiotensin converting enzyme 2 (ACE2) is the human cell receptor of SARS-CoV-2. • Receptor-ligand interactions, should be kept at the heart of scientific debate. • Ethnicity, environment, and behaviors factors interfere with these interactions. • Associated illness, and medications also ...
Kahroba, Houman Davatgaran-Taghipour, Yasamin
Published in
Biochimie
Accumulation of oxidative stress in cells is an essential feature of cellular senescence and aging. This phenomenon is involved in different age-related diseases through dysregulation of homeostasis and impairing repair and regeneration (wound healing) capacity, which can suppress antioxidant responses such as the activity of antioxidant enzymes an...
Ye, Shan Zeng, Rune Zhou, Jianyu An, Mingwei Ding, Zhong
Published in
Biochimie
Voltage-gated calcium channels (VGCCs) mediate the entry of Ca2+ ions into cells in response to membrane depolarization and play fundamental roles in the nervous system, and the α1 subunits are the main subunits of Ca2+ channels. Caenorhabditis elegans possesses genes encoding α1 subunits; however, very few of these genes have been cloned in plant-...
Shadrina, Olga Garanina, Irina Korolev, Sergey Zatsepin, Timofei Van Assche, Jeanne Daouad, Fadoua Wallet, Clementine Rohr, Olivier Gottikh, Marina
Published in
Biochimie
Human Ku heterodimeric protein composed of Ku70 and Ku80 subunits plays an important role in the non-homologous end-joining DNA repair pathway as a sensor of double strand DNA breaks. Ku is also involved in numerous cellular processes, and in some of them it acts in an RNA-dependent manner. However, RNA binding properties of the human Ku have not b...
Magnadóttir, Bergljót Uysal-Onganer, Pinar Kraev, Igor Svansson, Vilhjálmur Skírnisson, Karl Lange, Sigrun
Published in
Biochimie
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent enzymes which post-translationally convert arginine into citrulline in target proteins in an irreversible manner, leading to functional and structural changes in target proteins. Protein deimination can cause the generation of neo-epitopes, affect gene regulation an...
Cecilia, Colombero Sofía, Cárdenas Marcela, Venara Ayelen, Martin Patricia, Pennisi Marta, Barontini Susana, Nowicki
Published in
Biochimie
The importance of cytochrome P450 (CYP)-derived arachidonic acid (AA) metabolites, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) as tumor growth promotors has already been described in several cancer types. The aim of this study was to evaluate the role of these compounds in the biology of pheochromocytoma/paragangl...
Jafarzadeh, Meisam Soltani, Bahram M Soleimani, Masoud Hosseinkhani, Saman
Published in
Biochimie
Recent advances have revealed that lncRNAs play important roles in tumorigenesis. However, only a small number of functional lncRNAs have been well characterized, particularly in colorectal cancer. Therefore, more extensive studies are needed to identify and characterize these lncRNAs to better understand cancer progression. In the present study, u...
Letsiou, Sophia Félix, Rute C Cardoso, João C R Anjos, Liliana Mestre, Ana L Gomes, Henrique L Power, Deborah M
Published in
Biochimie
Cartilage acidic protein 1 (CRTAC1) is an extracellular matrix protein of human chondrogenic tissue that is also present in other vertebrates, non-vertebrate eukaryotes and in some prokaryotes. The function of CRTAC1 remains unknown but the protein's structure indicates a role in cell-cell or cell-matrix interactions and calcium-binding. The aim of...
Zhang, Gui-Xiong Liu, Yan-Lan Yang, Min Huang, Wen-Shan Xu, Jie-Hua
Published in
Biochimie
Aptamers which are promising and effective molecular probes, can deliver either fluorescent materials or radionuclides to tumors. This study aimed to develop a novel both fluorescent and radionuclide dual-modality probe based on a truncated aptamer and evaluate its stability and binding affinities in vitro. The aptamer JHIT2 with binding specifical...
