de Miranda, Marcelo Coutinho Ferreira, Andrea da Fonseca de Melo, Mariane Izabella Abreu Kunrath-Lima, Marianna Goes, Alfredo Miranda de Rodrigues, Michele Angela Gomes, Dawidson Assis Faria, Jerusa Araújo Quintão Arantes
Published in
Biochimie
It is becoming increasingly evident that mesenchymal stem/stromal cells are recruited by cancer cells from nearby endogenous host stroma and promote events such as tumor proliferation, angiogenesis, invasion, and metastasis, as well as mediate therapeutic resistance. Consequently, understanding the regulatory mechanisms of ASCs that influence the t...
Bortot, Leandro Oliveira Rangel, Victor Lopes Pavlovici, Francesca A El Omari, Kamel Wagner, Armin Brandao-Neto, Jose Talon, Romain von Delft, Frank Reidenbach, Andrew G Vallabh, Sonia M
...
Published in
Biochimie
Prion disease is caused by the misfolding of the cellular prion protein, PrPC, into a self-templating conformer, PrPSc. Nuclear magnetic resonance (NMR) and X-ray crystallography revealed the 3D structure of the globular domain of PrPC and the possibility of its dimerization via an interchain disulfide bridge that forms due to domain swap or by non...
Tsvetkov, Vladimir Varizhuk, Anna Kozlovskaya, Liubov Shtro, Anna Lebedeva, Olga Komissarov, Andrey Vedekhina, Tatjana Manuvera, Valentin Zubkova, Olga Eremeev, Artem
...
Published in
Biochimie
In the search for anti-SARS-CoV-2 drugs, much attention is given to safe and widely available native compounds. The green tea component epigallocatechin 3 gallate (EGCG) is particularly promising because it reportedly inhibits viral replication and viral entry in vitro. However, conclusive evidence for its predominant activity is needed. We tested ...
Maimoni Campanella, Jonatas Erick Ramos Junior, Sergio Luiz Rodrigues Kiraly, Vanessa Thomaz Severo Gomes, Antoniel Augusto de Barros, Andrea Coelho Mateos, Pablo Acera Freitas, Fernanda Zanolli de Mattos Fontes, Marcos Roberto Borges, Júlio Cesar Bertolini, Maria Célia
...
Published in
Biochimie
The RVB proteins, composed of the conservative paralogs, RVB1 and RVB2, belong to the AAA+ (ATPases Associated with various cellular Activities) protein superfamily and are present in archaea and eukaryotes. The most distinct structural features are their ability to interact with each other forming the RVB1/2 complex and their participation in seve...
Salman, Tabinda Afroz, Rushda Nawaz, Shazia Mahmood, Khalid Haleem, Darakhshan J Zarina, Shamshad
Published in
Biochimie
Methylphenidate (MPD), a psychostimulant, is a prescription medicine for treating attention deficit hyperactivity disorder (ADHD). Previously we have shown that moderate doses of MPD enhanced learning and memory while higher doses impaired it. To understand neurochemical mechanisms and receptors involved in memory enhancing and impairing effects of...
Brochier-Armanet, Céline Madern, Dominique
Published in
Biochimie
The NAD(P)-dependent malate dehydrogenases (MDH) (EC 1.1.1.37) and NAD-dependent lactate dehydrogenases (LDH) (EC. 1.1.1.27) form a large superfamily that has been characterized in organisms belonging to the three Domains of Life. MDH catalyzes the reversible conversion of the oxaloacetate into malate, while LDH operates at the late stage of glycol...
Ye, Wei Li, Saini Liu, Shuai Kong, Yali Zhang, Weiyang Liu, Shan Liu, Taomei Zhang, Weimin
Published in
Biochimie
Gliotoxins are epipolythiodioxopiperazine toxins produced by the filamentous fungi, which show great potential in the treatment of liver and lung cancer because of its cytotoxicity. In this study, three novel genes related to gliotoxin biosynthesis, gliT, gliM and gliK encoding thioredoxin reductase, O-methyltransferase and gamma-glutamyl cyclotran...
Beniaminov, Artemy Chashchina, Galina Shchyolkina, Anna Kaluzhny, Dmitry
Published in
Biochimie
Major advances have been made recently in the application of the highly selective G4 DNA ligand pyridostatin (PDS) for targeting and visualization of this noncanonical DNA structure in eukaryotic genomes. However, the interaction of PDS with the G4 structure constrained by double-stranded DNA has not yet been analyzed. Here, we induced folding of G...
Luo, Xuanjin Ouyang, Jianhong Wang, Yan Zhang, Minghui Fu, Lei Xiao, Ning Gao, Lianghui Zhang, Peng Zhou, Jiang Wang, Yipeng
...
Published in
Biochimie
Cathelicidin is a family of antimicrobial peptides (AMPs) existing in vertebrates, which play multiple functions in host responses against environmental stresses. All cathelicidins identified to date are cationic, no anionic member with net negative charges has been reported. In the present study, a novel anionic cathelicidin (TK-CATH) with a net c...
Verma, Smita Ravichandiran, Velayutham Ranjan, Nihar
Published in
Biochimie
Thioflavin T (ThT) is a commercially available fluorescent dye that is commonly used in biomedical research for over five decades. It was first reported as an extrinsic fluorescent probe for the detection of amyloid fibrils and related processes and it has also been used extensively for assessing protein binding in fluorescence-based assays. Althou...
