Ferreira, Graziele Cristina Bomediano Camillo, Lívia de Moraes Sasaki, Sergio Daishi
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Biochimie
Serine proteases are an important group of enzymes present in several organisms such as viruses, bacteria and eukaryotes involved in several physiological and pathological processes such as cancer, neurodegeneration, tissue inflammation and infections. Kunitz-type serine protease inhibitors have been studied as therapeutical targets with positive r...
Sudhakar Reddy, V Bhanuprakash Reddy, G
Published in
Biochimie
The small heat shock protein (sHsp) family is a group of proteins in which some are induced in response to external stimuli, such as environmental and pathological stresses, while others are constitutively expressed. They show chaperone-like activity, protect cells from apoptosis, and maintain cytoskeletal architecture. Short sequences or fragments...
Ramos-Martín, Francisco Herrera-León, Claudia Antonietti, Viviane Sonnet, Pascal Sarazin, Catherine D'Amelio, Nicola
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Biochimie
Sesquin is a wide spectrum antimicrobial peptide displaying a remarkable activity on fungi. Contrarily to most antimicrobial peptides, it presents an overall negative charge. In the present study, we elucidate the molecular basis of its mode of action towards biomimetic membranes by NMR and MD experiments. While a specific recognition of phosphatid...
Musabirova, Guzel Engberg, Oskar Gupta, Ankur Roy, Debsankar Saha Maiti, Sudipta Huster, Daniel
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Biochimie
Serotonin is an endogenous neurotransmitter involved in both physiological and pathophysiological processes. Traditionally, serotonin acts as a ligand for G protein-coupled receptors (GPCRs) leading to subsequent cell signaling. However, serotonin can also bind to lipid membranes with high affinity and modulate the phase behavior in 1-palmitoyl-2-o...
Magny, Romain Regazzetti, Anne Kessal, Karima Christin, Orane Baudouin, Christophe Roulland, Emmanuel Brignole-Baudouin, Françoise Laprévote, Olivier Auzeil, Nicolas
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Biochimie
Three new very long chain polyunsaturated fatty acids (VLC PUFA) belonging to the omega-3 family have been identified in meibum samples collected by Schirmer strips. These VLC PUFA, namely FA (32:3), FA (34:3) and FA (36:3), were detected in O-acyl-ω-hydroxy fatty acids using a molecular network approach, and as free fatty acids. Identification was...
Bakala-N'Goma, Jean-Claude Couëdelo, Leslie Vaysse, Carole Letisse, Marion Pierre, Véronique Géloen, Alain Michalski, Marie-Caroline Lagarde, Michel Leao, Jean-David Carrière, Frédéric
...
Published in
Biochimie
The specific activities of gastric and pancreatic lipases were measured using triacylglycerols (TAG) from rapeseed oil, purified 1,3-sn-DAG and 1,2(2,3)-sn-DAG produced from this oil, as well as a rapeseed oil enriched with 40% w/w DAG (DAGOIL). Gastric lipase was more active on 1,3-sn-DAG than on 1,2(2,3)-sn-DAG and TAG, whereas pancreatic lipase ...
Soulié, Marine Deletraz, Anais Wehbie, Moheddine Mahler, Florian Bouchemal, Ilham Le Roy, Aline Keller, Sandro Meister, Annette Pebay-Peyroula, Eva Breyton, Cécile
...
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Biochimie
We report herein the synthesis of zwitterionic sulfobetaine (SB) and dimethylamine oxide (AO) detergents whose alkyl chain is made of either a perfluorohexyl (F6H3) or a perfluoropentyl (F5H5) group linked to a hydrogenated spacer arm. In aqueous solution, the critical micellar concentrations (CMCs) measured by surface tensiometry (SFT) and isother...
Philippe, Aurélien Puel, Mathilde Narjoz, Céline Gendron, Nicolas Durey-Dragon, Marie Agnès Vedie, Benoit Balduyck, Malika Chocron, Richard Hauw-Berlemont, Caroline Sanchez, Olivier
...
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Biochimie
Thrombosis is a hallmark of severe COVID-19. Alpha-1-antitrypsin (AAT), an inflammation-inducible serpin with anti-inflammatory, tissue protective and anticoagulant properties may be involved in severe COVID-19 pathophysiology including thrombosis onset. In this study, we examined AAT ability to predict occurrence of thrombosis and in-hospital mort...
Turpin, Chloé Meilhac, Olivier Bourdon, Emmanuel Canonne-Hergaux, François Rondeau, Philippe
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Biochimie
Red blood cells (RBC) are the most abundant circulating cell of the human body. RBC are constantly exposed to multiple stresses in the circulation, leading to molecular and structural impairments and death. The physiological process of RBC senescence or ageing is referred to as eryptosis. At the end of their lifespan, aged RBC are recognized and re...
Gnocchi, Davide Kurzyk, Agata Mintrone, Antonella Lentini, Giovanni Sabbà, Carlo Mazzocca, Antonio
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Biochimie
Hepatocellular carcinoma (HCC) is one of the most threatening tumours in the world today. Pharmacological treatments for HCC mainly rely on protein kinase inhibitors, such as sorafenib and regorafenib. Even so, these approaches exhibit side effects and acquired drug resistance, which is an obstacle to HCC treatment. We have previously shown that se...