Adventures with Mike.
Published in Biochimica et biophysica acta. Molecular cell research
Here are a few personal recollections of my 'big adventure' with Mike. Copyright © 2020 Elsevier B.V. All rights reserved.
The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CRE...
Published in Biochimica et biophysica acta. Molecular cell research
Molybdenum cofactor biology, evolution and deficiency.
Published in Biochimica et biophysica acta. Molecular cell research
The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global scale. Given the diversity of biological processes dependent on Moco and their evolutionary age, Moco is traced back to the last universal common ancestor (LUCA), while Moco ...
Zinc homeostasis and signaling in the roundworm C. elegans.
Published in Biochimica et biophysica acta. Molecular cell research
C. elegans is a powerful model for studies of zinc biology. Here we review recent discoveries and emphasize the advantages of this model organism. Methods for manipulating and measuring zinc levels have been developed in or adapted to the worm. The C. elegans genome encodes highly conserved zinc transporters, and their expression and function are b...
Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production...
...Published in Biochimica et biophysica acta. Molecular cell research
Mitochondria are highly dynamic organelles. Alterations in mitochondrial dynamics are causal or are linked to numerous neurodegenerative, neuromuscular, and metabolic diseases. It is generally thought that cells with altered mitochondrial structure are prone to mitochondrial dysfunction, increased reactive oxygen species generation and widespread o...
A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes c...
Published in Biochimica et biophysica acta. Molecular cell research
We have recently reported that phosphatidylethanolamine (PE)-containing liposomes are endocytosed and then induce lipid droplets (LDs) in HEK293T cells. In this study, we elucidated a mechanism responsible for endocytosis of PE-containing liposomes and induction of LDs. By using fluorescence-labeled liposomes and flow cytometry, we found that PE-co...
Fungal iron homeostasis with a focus on Aspergillus fumigatus.
Published in Biochimica et biophysica acta. Molecular cell research
To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization to ensure sufficient supply and to avoid toxic excess of this essential trace element. As pathogens usually encounter iron limitation in the host niche, this metal plays a particular role during virulence. Siderophores are iron-chelators synthesized by mo...
Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch applicatio...
Published in Biochimica et biophysica acta. Molecular cell research
Dysfunctions of vascular smooth muscle cells (VSMCs) play crucial roles in vascular remodeling in hypertension, which correlates with pathologically elevated cyclic stretch due to increased arterial pressure. Recent researches reported that autophagy, a life-sustaining process, was increased in hypertension. However, the mechanobiological mechanism...
Kisspeptin preserves mitochondrial function by inducing mitophagy and autophagy in aging rat brain hippocampus and human...
Published in Biochimica et biophysica acta. Molecular cell research
It has become amply clear that mitochondrial function defined by quality, quantity, dynamics, homeostasis, and regulated by mitophagy and mitochondrial biogenesis is a critical metric of human aging and disease. As a consequence, therapeutic interventions that can improve mitochondrial function can have a profound impact on human health and longevi...
Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing g...
Published in Biochimica et biophysica acta. Molecular cell research
Lysophosphatidic acid (LPA) via transactivation dependent signalling pathways contributes to a plethora of physiological and pathophysiological responses. In the vasculature, hyperelongation of glycosaminoglycan (GAG) chains on proteoglycans leads to lipid retention in the intima resulting in the early pathogenesis of atherosclerosis. Therefore, we...
