Kang, Le Wang, Xinhua Wang, Jianfang Guo, Jing Zhang, Wang Lei, Ruirui
Published in
Biochimica et biophysica acta. General subjects
Excessive inflammation is the main cause of treatment failure in neonatal pneumonia (NP). CCCTC-binding factor (CTCF) represents an important node in various inflammatory diseases. In the present study, we tried to clarify the function and underlying molecular mechanism of CTCF on an in vitro cellular model of NP, which was generated by simulating ...
Khalid, Asimah Naseem, Imrana
Published in
Biochimica et biophysica acta. General subjects
The global prevalence of diabetes has increased sharply, with the number of cases expected to rise from 424.9 million in 2017 to 628.6 million by 2045. Flavonoids are plant derived molecules with well-established antioxidant potential in addition to other therapeutic properties. Silibinin is a naturally occurring flavonoid with antioxidant and anti...
Reutovich, Aliaksandra A Srivastava, Ayush K Arosio, Paolo Bou-Abdallah, Fadi
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Biochimica et biophysica acta. General subjects
The development of safe and effective vaccines against SARS-CoV-2 and other viruses with high antigenic drift is of crucial importance to public health. Ferritin is a well characterized and ubiquitous iron storage protein that has emerged not only as a useful nanoreactor and nanocarrier, but more recently as an efficient platform for vaccine develo...
Gorman, Brittney L Torti, Suzy V Torti, Frank M Anderton, Christopher R
Published in
Biochimica et biophysica acta. General subjects
Metals are pervasive throughout biological processes, where they play essential structural and catalytic roles. Metals can also exhibit deleterious effects on human health. Powerful analytical techniques, such as mass spectrometry imaging (MSI), are required to map metals due to their low concentrations within biological tissue. This Mini Review fo...
Mazrouei, Safoura Petry, Sebastian Friedrich Sharifpanah, Fatemeh Javanmard, Shaghayegh Haghjooy Kelishadi, Roya Schulze, P Christian Franz, Marcus Jung, Christian
Published in
Biochimica et biophysica acta. General subjects
There is great interest to understand causal pathophysiological correlation between obesity and diabetes mellitus (DM). Vascular endothelial dysfunction is crucially involved in pathogenesis of vascular complications in DM. Recently, increased arginase expression and activity have been described as underlying mechanisms of endothelial dysfunction i...
Nguyet, Vo Thi Anh Furutani, Noboru Ando, Ryoko Izawa, Shingo
Published in
Biochimica et biophysica acta. General subjects
Although the budding yeast, Saccharomyces cerevisiae, produces ethanol via alcoholic fermentation, high-concentration ethanol is harmful to yeast cells. Severe ethanol stress (> 9% v/v) inhibits protein synthesis and increases the level of intracellular protein aggregates. However, its effect on proteolysis in yeast cells remains largely unknown. W...
Bakman, Artemiy S Ishchenko, Alexander A Saparbaev, Murat Fedorova, Olga S Kuznetsov, Nikita A
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Biochimica et biophysica acta. General subjects
Human apurinic/apyrimidinic endonuclease APE1 catalyzes endonucleolytic hydrolysis of phosphodiester bonds on the 5' side of structurally unrelated damaged nucleotides in DNA or native nucleotides in RNA. APE1 additionally possesses 3'-5'-exonuclease, 3'-phosphodiesterase, and 3'-phosphatase activities. According to structural data, endo- and exonu...
Żaczek, Szymon Dybala-Defratyka, Agnieszka
Published in
Biochimica et biophysica acta. General subjects
Prenylated flavin mononucleotide (prFMN) is a recently discovered, heavily modified flavin compound. It is the only known cofactor that enables enzymatic 1,3-dipolar cycloaddition reactions. It is produced by enzymes from the UbiX family, from flavin mononucleotide and either dimethylallyl mono- or diphosphate. prFMN biosynthesis is currently repor...
Fiore, Ana Paula Zen Petisco Rodrigues, Ana Maria Ribeiro-Filho, Helder Veras Manucci, Antonio Carlos de Freitas Ribeiro, Pedro Botelho, Mayara Carolinne Silva Vogel, Christine Lopes-de-Oliveira, Paulo Sergio Pagano, Michele Bruni-Cardoso, Alexandre
...
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Biochimica et biophysica acta. General subjects
The Hippo pathway plays central roles in relaying mechanical signals during development and tumorigenesis, but how the proteostasis of the Hippo kinase MST2 is regulated remains unknown. Here, we found that chemical inhibition of proteasomal proteolysis resulted in increased levels of MST2 in human breast epithelial cells. MST2 binds SCFβTrCP E3 ub...
Ramalho, Suellen Rodrigues de Cássia Orlandi Sardi, Janaina Júnior, Edson Crusca Marchetto, Reinaldo Wender, Heberton Vargas, Luiz Felipe Plaça de Miranda, Antonio Almeida, Claudiane Vilharroel de Oliveira Almeida, Luís Henrique de Oliveira, Caio Fernando Ramalho
...
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Biochimica et biophysica acta. General subjects
Antimicrobial peptides (AMPs) are promising tools for developing new antibiotics. We described the design of IKR18, an AMP designed with the aid of computational tools. IKR18 showed antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). CD studies revealed that IKR18 as...
