Yang, Qian Wang, Mengyi Wang, Huan Ren, Cheng Li, Yifu
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Diabetic kidney disease (DKD) is a major contributor to chronic kidney disease. Hydrogen sulfide (H2S) serves as an endogenous gaseous signaling molecule capable of safeguarding renal function within the context of DKD. However, the underlying mechanisms need to be elucidated. This study was undertaken to unveil the mechanisms by which H2S countera...
Morin, Claire Verma, Vijay Tailor Arya, Tarun Casu, Bastien Jolicoeur, Eric Ruel, Réjean Marinier, Anne Sygusch, Jurgen Baron, Christian
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Biochemistry and cell biology = Biochimie et biologie cellulaire
We here describe the structure-based design of small molecule inhibitors of the type IV secretion system of Helicobacter pylori. The secretion system is encoded by the cag pathogenicity island, and we chose Cagα, a hexameric ATPase and member of the family of VirB11-like proteins, as target for inhibitor design. We first solved the crystal structur...
Li, Kemin Li, Tian Niu, Yanan Gao, Yu Shi, Yifan He, Yifan Zhang, Xuanping Wang, Yan Cao, Jing Hu, Xiaoling
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Mitoxantrone (MX) is an effective treatment for breast cancer; however, high efflux of MX that is accomplished by breast cancer resistance protein (BCRP) leads to acquired multidrug resistance (MDR), reducing MX's therapeutic efficacy in breast cancer. Non-muscle myosin IIA (NMIIA) and its heavy phosphorylation at S1943 have been revealed to play k...
Leyden, Melissa R Gowen, Brent Gonzalez-Romero, Rodrigo Eirin-Lopez, Jose Maria Kim, Bo-Hyun Hayashi, Fumio McCartney, Jay Zhang, Patrick C Kubo-Irie, Miyoko Shabanowitz, Jeffrey
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Insects are the largest group of animals when it comes to the number and diversity of species. Yet, with the exception of Drosophila, no information is currently available on the primary structure of their sperm nuclear basic proteins (SNBPs). This paper represents the first attempt in this regard and provides information about six species of Neopt...
Lapointe, Vanessa Couture, Frédéric
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Neutrophil myeloperoxidase/H2O2/chloride system is a key mechanism to control pathogen infection. This enzyme, myeloperoxidase, plays a pivotal role in the arsenal of azurophilic granules that are released through degranulation upon neutrophil activation, which trigger local hypochlorous acid production. Myeloperoxidase gene encodes a protein precu...
Ausió, Juan Knox, Alistair Kim, Bo-Hyun Humphrey, Elaine Gowen, Brent Minamino, Naoki von Aderkas, Patrick
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Sperm nuclear basic proteins (SNBPs) were isolated from extracted antheridia-rich male gametophytes raised from spores of the swordfern, Polystichum munitum. Electrophoretic (acetic acid-urea PAGE and SDS-PAGE) and chromatographic (rp-HPLC) characterization of the nuclear proteins exhibited the characteristics of the histone (H-type). In both types...
Jurkovic, Carla-Marie Boisvert, François-Michel
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Understanding the complex network of protein-protein interactions (PPI) that govern cellular functions is essential for unraveling the molecular basis of biological processes and diseases. Mass spectrometry (MS) has emerged as a powerful tool for studying protein dynamics, enabling comprehensive analysis of protein function, structure, post-transla...
Tiwari, Saurabh Shahat, Abdallah Kastelic, John Thakor, Nehal Thundathil, Jacob
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Increasing evidence of sperm RNA's role in fertilization and embryonic development has provided impetus for its isolation and thorough characterization. Sperm are considered tough-to-lyse cells due to the compact condensed DNA in sperm heads. Lack of consensus among bovine sperm RNA isolation protocols introduces experimental variability in transcr...
Cao, Xiaofang Zhang, Yan Shi, Yu Li, Ying Gao, Li Wang, Xiumei Sun, Liang
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Mitochondria play a critical role in nerve regeneration, yet the impact of gene expression changes related to mitochondria in facial nerve regeneration remains unknown. To address this knowledge gap, we analyzed the expression profile of the facial motor nucleus (FMN) using data obtained from the Gene Expression Omnibus (GEO) database (GSE162977). ...
Jacobs, Joadi Iranpour, Rosa Behrooz, Amir Barzegar da Silva Rosa, Simone C Ghavami, Saeid
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Biochemistry and cell biology = Biochimie et biologie cellulaire
Glioblastoma (GBM) is the most common aggressive central nervous system cancer. GBM has a high mortality rate, with a median survival time of 12-15 months after diagnosis. A poor prognosis and a shorter life expectancy may result from resistance to standard treatments such as radiation and chemotherapy. Temozolomide has been the mainstay treatment ...
