Morimoto, Daichi Walinda, Erik Takashima, Shingo Nishizawa, Mayu Iwai, Kazuhiro Shirakawa, Masahiro Sugase, Kenji
Published in
Biochemistry
Polyubiquitin is a multifunctional protein tag formed by the covalent conjugation of ubiquitin molecules. Due to the high rigidity of the ubiquitin fold, the ubiquitin moieties in a polyubiquitin chain appear to be structurally equivalent to each other. It is therefore unclear how a specific ubiquitin moiety in a chain may be preferentially recogni...
Pattnaik, Gourab Prasad Bhattacharjya, Surajit Chakraborty, Hirak
Published in
Biochemistry
Membrane fusion is an important step for the entry of the lipid-sheathed viruses into the host cells. The fusion process is being carried out by fusion proteins present in the viral envelope. The class I virus contains a 20–25 amino acid sequence at its N-terminal of the fusion domain, which is instrumental in fusion and is called as a “fusion pept...
Zhong, Aoshu Lee, Yu-Hsuan Liu, Yung-nan Liu, Hung-wen
Published in
Biochemistry
Kirpich, Julia S Chang, Che-Wei Franse, Jasper Yu, Qinhong Escobar, Francisco Velazquez Jenkins, Adam J Martin, Shelley S Narikawa, Rei Ames, James B Lagarias, J Clark
...
Published in
Biochemistry
Cyanobacteriochromes (CBCRs) are cyanobacterial photoreceptors that exhibit photochromism between two states: a thermally stable dark-adapted state and a metastable light-adapted state with bound linear tetrapyrrole (bilin) chromophores possessing 15Z and 15E configurations, respectively. The photodynamics of canonical red/green CBCRs have been ext...
Smith, Ryan H B Khan, Zaigham M Ung, Peter Man-Un Scopton, Alex P Silber, Lisa Mack, Seshat M Real, Alexander M Schlessinger, Avner Dar, Arvin C
Published in
Biochemistry
Pseudokinases play important roles in signal transduction and cellular processes similar to those of catalytically competent kinases. However, pseudokinase pharmacological tractability and conformational space accessibility are poorly understood. Pseudokinases have only recently been suggested to adopt "inactive" conformations or interact with conf...
Palacios-Ortega, Juan Rivera-de-Torre, Esperanza García-Linares, Sara Gavilanes, José G Martínez-Del-Pozo, Álvaro Slotte, J Peter
Published in
Biochemistry
Sticholysins are pore-forming toxins produced by sea anemones that are members of the actinoporin family. They exert their activity by forming pores on membranes, provided they have sphingomyelin. To assemble into pores, specific recognition, binding, and oligomerization are required. While recognition and binding have been extensively studied, del...
Buhrman, Greg Enríquez, Paul Dillard, Lucas Baer, Hayden Truong, Vivian Grunden, Amy M Rose, Robert B
Published in
Biochemistry
2-Oxoglutarate carboxylase (OGC), a unique member of the biotin-dependent carboxylase family from the order Aquificales, captures dissolved CO2 via the reductive tricarboxylic acid (rTCA) cycle. Structure and function studies of OGC may facilitate adaptation of the rTCA cycle to increase the level of carbon fixation for biofuel production. Here we ...
Hongdusit, Akarawin Fox, Jerome M
Published in
Biochemistry
Allosteric regulation enables dynamic adjustments to protein function that permit tight control over cellular biochemistry. Discrepancies in the allosteric systems of related proteins can thus reveal important differences in their susceptibilities to influential stimuli (e.g., allosteric ligands, mutations, or post-translational modifications). Thi...
Petrik, Igor D Davydov, Roman Kahle, Maximilian Sandoval, Braddock Dwaraknath, Sudharsan Ädelroth, Pia Hoffman, Brian Lu, Yi
Published in
Biochemistry
Efficiently carrying out the oxygen reduction reaction (ORR) is critical for many applications in biology and chemistry, such as bioenergetics and fuel cells, respectively. In biology, this reaction is carried out by large, transmembrane oxidases such as heme-copper oxidases (HCOs) and cytochrome bd oxidases. Common to these oxidases is the presenc...
Tararina, Margarita A Dam, Katie K Dhingra, Manaswni Janda, Kim D Palfey, Bruce A Allen, Karen N
Published in
Biochemistry
In Pseudomonas putida, the flavoprotein nicotine oxidoreductase (NicA2) catalyzes the oxidation of (S)-nicotine to N-methyl-myosmine, which is nonenzymatically hydrolyzed to pseudooxynicotine. Structural analysis reveals a monoamine oxidase (MAO)-like fold with a conserved FAD-binding domain and variable substrate-binding domain. The flavoenzyme ha...