Du, Yiwen Wang, Longling Zhou, Jingmei Hong, Wenxiang Cai, Xuanyan Ma, Hongbo Wei, Zonghui Nie, Wenwen Zhu, Hong Yang, Bo
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Published in
Biochemical pharmacology
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent eczematous lesions and severe itching, for which clinical treatments are limited. Selectively inhibiting Janus Kinase 3 (JAK3) and tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases is proposed as a promising strategy to treat AD with p...
Wang, Zihe Deng, Wei Tang, Kai Zhou, Yi Chen, Junchun Wang, Bin Zhang, Zhida Zou, Jian Zhao, Wenhua
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Biochemical pharmacology
Osteoporosis is characterized by excessive osteoclast activity leading to bone loss, decreased bone mineral density, and increased susceptibility to fractures. Through in vivo/vitro experiments, along with network pharmacology analysis, we aimed to explore the underlying mechanisms of Isoginkgetin (IGG) in inhibiting osteoclastogenesis, providing v...
Mattoo, Shria Arora, Muskaan Sharma, Priyanka Pore, Subrata Kumar
Published in
Biochemical pharmacology
Regulated protein degradation plays a crucial role in maintaining proteostasis along with protein refolding and compartmentalisation which collectively control biological functions. The N-end rule pathway is a major ubiquitin-dependent protein degradation system. The short-lived protein substrates containing destabilizing amino acid residues (N-deg...
Coccè, Valentina Bonelli, Mara Monica, Silvia La Alfieri, Roberta Doneda, Luisa Martegani, Eleonora Alessandri, Giulio Lagrasta, Costanza Annamaria Giannì, Aldo Sordi, Valeria
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Published in
Biochemical pharmacology
Ren, Zhaozhou Liu, Jie Chang, Xiyue Yang, Xuejing Zhang, Yuke Zhang, Xinyue Zhou, Siyu Liang, Qiushi Xu, Zhijie Yang, Fan
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Published in
Biochemical pharmacology
The peptides encoded by long noncoding RNAs (lncRNAs) have been shown to participate in cancer pathogenesis. In this study, lncRNA LINC00944 was validated to encode an endogenous 102-amino acid (aa) small peptide (named LINC00944 peptide). Functionally, LINC00944 peptide exerted an anti-growth effect in melanoma cells in vitro. Mechanistically, LIN...
Du, Wei Rahman, Sabrina N Barker, Eleanor Bräuner-Osborne, Hans Mathiesen, Jesper M Ward, Donald T Jensen, Anders A
Published in
Biochemical pharmacology
The calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and small-molecule and peptide positive allosteric modulators (PAMs) of CaSR, so-called calcimimetics, are used in the treatment of hyperparathyroidism and hypocalcemic disorders. In this study, four monovalent nanobodies - representing four distinct nanobody families with...
Liu, Zhiming Yoon, Chi-Su Lee, Hwan Kim, Eunae Yim, Joung Han Kim, Tai Kyoung Oh, Hyuncheol Lee, Dong-Sung
Published in
Biochemical pharmacology
Ramalin, a strong antioxidant isolated from Antarctic lichens, has been shown to have potential therapeutic effects in the treatment of Alzheimer's disease. However, this compound is readily degraded in aqueous solutions, which restricts its development as a therapeutic agent. With a view toward addressing this problem, in this study, we modified t...
Zhang, Qianbo Gu, Rifang Dai, Yuhe Chen, Jitao Ye, Penghui Zhu, Huan He, Wenping Nie, Xuqiang
Published in
Biochemical pharmacology
Wound healing is a complex biological process involving multiple cellular and molecular mechanisms. Ubiquitination, a crucial post-translational modification, plays a vital role in regulating various aspects of wound healing through protein modification and degradation. This review comprehensively examines the molecular mechanisms of ubiquitination...
Tang, Minyi Wang, Xinzi Wang, Shuai Xing, Chaofeng Xu, Qihua Mu, Yunping Wu, Xiaoli Zhao, Zijian Allan Li, Fanghong
Published in
Biochemical pharmacology
Nonalcoholic fatty liver disease (NAFLD) originates from metabolic dysfunctions, is one of the most commonly encountered liver disorders worldwide, characterized by ectopic lipid deposition within hepatocytes, accompanied by hepatocellular injury and necroinflammation. Currently, NAFLD has very few treatment options. Purified from royal jelly, 10-h...
Noronha-Matos, José Bernardo Sousa-Soares, Carlos Correia-de-Sá, Paulo
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Biochemical pharmacology
Nicotinic α7 receptors (α7 nAChRs) present in perisynaptic Schwann cells (PSCs) control acetylcholine (ACh) spillover from the neuromuscular synapse by transiently increasing intracellular Ca2+, which fosters adenosine release via type 1 equilibrative nucleoside transporters (ENT1) and retrograde activation of presynaptic A1 inhibitory receptors. T...