Liu, Jie Nie, Hongtao Huo, Zhongming Yan, Xiwu
Published in
Biochemical genetics
Studies have shown that the shellfish have innate immune system, which is a very important immune form of shellfish, and they rely on the innate immune system to resist diseases. As a transcription factor, Microphthalmia-associated transcription factor (MITF) plays a regulatory role in immune response and the shell color is also an important index ...
Zhu, Jiwen Zhang, Jiayao Hu, Peng Fan, Mingxiang Song, Dianwen Yin, Huabin Yan, Penghui Xian, Shuyuan Li, Zhenyu Guo, Juanru
...
Published in
Biochemical genetics
As the most common nonepithelial malignancy, prostate adenocarcinoma (PRAD) is the fifth chief cause of cancer mortality in men. Distant metastasis often occurs in advanced PRAD and most patients are dying from it. However, the mechanism of PRAD progression and metastasis is still unclear. It's widely reported that more than 94% of genes are select...
Chen, Zhao-Jun Xiao, Jie Chen, Hai-Hua
Published in
Biochemical genetics
COVID-19 has spread all over the world which poses a serious threat to social economic development and public health. Despite enormous progress has been made in the prevention and treatment of COVID-19, the specific mechanism and biomarker related to disease severity or prognosis have not been clarified yet. Our study intended to further explore th...
Faraji, Niloofar Abbaspour, Saima Ajamian, Farzam Keshavarz, Parvaneh
Published in
Biochemical genetics
Genetic factors are known to play a significant role in the susceptibility of diabetic patients to severe complications such as diabetic nephropathy (DN). This study aimed to evaluate the association between polymorphism of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) variants (rs997509, K121Q, rs1799774, and rs7754561) and DN in pati...
Hu, Di Lin, Zenan Li, Pan Zhang, Zhehuan Jiang, Junhong Yang, Chenhao
Published in
Biochemical genetics
Keratoconus is one of the most common causes leading to visual impairment in young adult population. The pathogenesis of keratoconus remains poorly understood. The aim of this study was to identify the potential key genes and pathways associated with keratoconus and to further analyze its molecular mechanism. Two RNA-sequencing datasets of keratoco...
Malekmohammadi, Laleh Sheidai, Masoud Ghahremaninejad, Farrokh Danehkar, Afshin Koohdar, Fahimeh
Published in
Biochemical genetics
The genus Avicennia with eight species grow in intertidal zones of tropical and temperate regions, ranging in distribution from West Asia, to Australia, and Latin America. These mangroves have several medicinal applications for mankind. Many genetic and phylogenetic studies have been carried out on mangroves, but none is concerned with geographical...
Rahimi, Ataollah Kahrizi, Danial Mirmoayedi, Alinaghi Zarei, Leila Jamali, Samad
Published in
Biochemical genetics
The genetic characterization of the Iranian honey bee was investigated by analyzing 10 polymorphic DNA microsatellite loci in 300 honey bee samples representative of twenty Iranian provinces. This study evaluated the heterozygosity (Ho and He), the Shannon index, the number of observed alleles, and F-statistics among tested populations as genetic p...
Wu, Haiyan Wang, Aikun Wang, Lisheng Shi, Feng Lin, Fengli Cui, Hengfeng
Published in
Biochemical genetics
Breast cancer (BC) is one of the most common malignant tumors in women. CircRNA/miRNA/mRNA regulatory axes have been shown to be involved in the pathogenesis of BC. Here, we sought to analyze the functional mechanism of circ_0104345 in BC. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the levels of circ_0104345,...
Shi, Yi Wu, Lixing Ji, Xuenian Li, Yunru Zhang, Zhicheng
Published in
Biochemical genetics
Previous studies found that the circadian clock gene participated in the genesis and development of breast cancer. However, research findings on the relationship between polymorphisms in the CLOCK gene and breast cancer risk were inconsistent. This study performed a meta-analysis of the association between CLOCK gene polymorphisms and breast cancer...
Banerjee, Pratibha Chaudhary, Ramprasad Singh, Atul Kumar Parulekar, Pratima Kumar, Shashank Senapati, Sabyasachi
Published in
Biochemical genetics
Immunogenicity of gliadin peptides in celiac disease (CD) is majorly determined by the pattern of molecular interactions with HLA-DQ and T-cell receptors (TCR). Investigation of the interactions between immune-dominant gliadin peptides, DQ protein, and TCR are warranted to unravel the basis of immunogenicity and variability contributed by the genet...
