Li, Yu Hu, Kaishun Xiao, Xing Wu, Wenjing Yan, Haiyan Chen, Hengxing Chen, Zhen Yin, Dong
Published in
Biochemical and biophysical research communications
FBW7 is an E3 ubiquitin ligase and frequently mutated in various types of cancer. As a component of SCF ubiquitin ligase complex, FBW7 usually targets the substrates via K11 or K48-linked ubiquitylation and subsequent degradation of target proteins. Nevertheless, the role of FBW7 in mediating non-degradable ubiquitin signaling remains unknown in hu...
Igarashi, Kentaro Kawaguchi, Kei Kiyuna, Tasuku Miyake, Kentaro Miyake, Masuyo Singh, Arun S Eckardt, Mark A Nelson, Scott D Russell, Tara A Dry, Sarah M
...
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Biochemical and biophysical research communications
Undifferentiated soft tissue sarcoma (USTS) is a recalcitrant and heterogeneous subgroup of soft tissue sarcoma with high risk of metastasis and recurrence. Due to heterogeneity of USTS, there is no reliably effective first-line therapy. We have generated tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R), which previously showed str...
Maalej, Marwa Kammoun, Thouraya Alila-Fersi, Olfa Kharrat, Marwa Ammar, Marwa Felhi, Rahma Mkaouar-Rebai, Emna Keskes, Leila Hachicha, Mongia Fakhfakh, Faiza
...
Published in
Biochemical and biophysical research communications
Leigh syndrome (LS) is a rare progressive neurodegenerative disorder occurring in infancy. The most common clinical signs reported in LS are growth retardation, optic atrophy, ataxia, psychomotor retardation, dystonia, hypotonia, seizures and respiratory disorders. The paper reported a manifestation of 3 Tunisian patients presented with LS syndrome...
Saikia, Karabi Chaudhary, Nitin
Published in
Biochemical and biophysical research communications
Antimicrobial peptides are critical components of defense systems in living forms. The activity is conferred largely by the selective membrane-permeabilizing ability. In our earlier work, we derived potent antimicrobial peptides from the 9-residue long, N-terminal amphipathic helix of E. coli MreB protein. The peptides display broad-spectrum activi...
Zhu, Guo-Dong Liu, Feng OuYang, Shi Zhou, Rui Jiang, Fu-Neng Zhang, Bei Liao, Wang-Jun
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Biochemical and biophysical research communications
The present study was to investigate clinical significance, biological functions and underlying mechanisms of BTB Domain and CNC Homolog 1(BACH1) deregulation in human colorectal cancer (CRC). The result showed that BACH1 upregulation was significantly associated with enhanced tumor invasion (P = 0.014) and gender (P = 0.028) of CRC patients. Kapla...
Ogura, Naoki Ogawa, Kazuya Watashi, Koichi Ito, Takayoshi Wakita, Takaji
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Biochemical and biophysical research communications
Chronic hepatitis B virus (HBV) infection is currently a major public health burden. Therefore, there is an urgent need for the development of novel antiviral inhibitors. The stable HBV-producing cell lines of genotype D are widely used to investigate the HBV life cycle and to evaluate antiviral agents. However, stable HBV-producing cell lines of d...
Li, Xiangxiao Sun, Weihong Xi, Wenda Shen, Weili Wei, Tong Chen, Wendong Gao, Pingjin Li, Qun
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Biochemical and biophysical research communications
Skin mesenchymal stem cells (S-MSCs) revealed an important immunomodulatory activity to markedly suppress the formation of the atherosclerosis (AS) plaque by modulating macrophages, and also inhibit the development of experimental autoimmune encephalomyelitis (EAE) by regulating T helper 17 (Th17) cell differentiation. Macrophages and Th17 cells pl...
Alila-Fersi, Olfa Tabebi, Mouna Maalej, Marwa Belguith, Neila Keskes, Leila Mkaouar-Rebai, Emna Fakhfakh, Faiza
Published in
Biochemical and biophysical research communications
Mitochondria are essential for early cardiac development and impaired mitochondrial function was described associated with heart diseases such as hypertrophic or dilated mitochondrial cardiomyopathy. In this study, we report a family including two individuals with severe dilated mitochondrial cardiomyopathy. The whole mitochondrial genome screening...
Qin, Shaolan Zhou, Yong Chen, Jianjun Yang Luo Qiu, Yier Tu, Shuiping Zhong, Ming
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Biochemical and biophysical research communications
Transforming growth factor β-stimulated clone 22 domain 1 (TSC22) has been identified as a cancer suppressor gene in various kinds of cancers. The purpose of this study was to explore the expression of TSC22 in colorectal cancer (CRC) tissues and cell lines. 24 matched CRC and normal tissue samples by qPCR along with 18 pairs of them by Western blo...
Noguchi, Hiroki Mylemans, Bram De Zitter, Elke Van Meervelt, Luc Tame, Jeremy R H Voet, Arnout
Published in
Biochemical and biophysical research communications
β-propeller proteins are highly symmetrical, being composed of a repeated motif with four anti-parallel β-sheets arranged around a central axis. Recently we designed the first completely symmetrical β-propeller protein, Pizza6, consisting of six identical tandem repeats. Pizza6 is expected to prove a useful building block for bionanotechnology, and...
