Khokhlova, Anastasia Myachina, Tatiana Butova, Xenia Volzhaninov, Denis Berg, Valentina Kochurova, Anastasia Kuznetsov, Daniil Mukhlynina, Elena Kopylova, Galina Shchepkin, Daniil
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Published in
Biochemical and biophysical research communications
Estrogen deficiency has a significant influence on the excitation-contraction coupling in the ventricular myocardium but its impact on the atrial contractile function has not been studied. We have compared the effects of estrogen deficiency on the contractility and cytosolic Ca2+ transient of single cardiomyocytes isolated from the left atrium (LA)...
Suda, Yukari Nakashima, Toshihisa Matsumoto, Hiroaki Sato, Daisuke Nagano, Satoshi Mikata, Haruka Yoshida, Sara Tanaka, Kenichi Hamada, Yusuke Kuzumaki, Naoko
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Published in
Biochemical and biophysical research communications
Hypothalamic aging is considered to be critical for systemic aging, and the accumulation of "exhausted glial cells" in the hypothalamus may contribute to brain dysfunction. In this study, we used normal aging mice and investigated aging-specific transcriptional identities of microglia and astrocytes in the hypothalamus. We confirmed that normal agi...
Hu, Guangrong He, Yonghan Li, Yaozong Hu, Xiao Liu, Sida Liao, Chang Zhang, Rui Zhou, Xinyao Sun, Hui
Published in
Biochemical and biophysical research communications
Chronic hypoxia plays an important role in the initiation and progression of chronic renal disease. The pathogenic role of chronic hypoxia in tubulointerstitial injury has been investigated widely, but little is known about acute hypoxia implications in glomerular damage. In this study, we investigated the effect of chronic hypoxia on transient rec...
Zhao, Xiangyu Zhang, Guirong Wu, Liuzhong Tang, Yulong Guo, Chuanbo
Published in
Biochemical and biophysical research communications
Bone marrow mesenchymal stem cells (BMMSCs) are characterized by their pluripotent differentiation and self-renewal capability and have been widely applied in regenerative medicine, gene therapy, and tissue repair. However, inflammatory response after BMMSCs transplantation was found to impair the osteogenic differentiation of BMMSCs. Thus, underst...
Chelluri, Lakshmi Kiran Mohanram, Yamuna Jain, Rashi Mallarpu, Chandra Shekar Ponnana, Meenakshi Kumar, Deepak Krishna Venuganti, Venkata Vamsi Kancherla, Ravindranath Papineni, Rao Vl Towner, Rheal
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Published in
Biochemical and biophysical research communications
A scientific approach is presented describing the fabrication of nanoprobe (GloTrack) that can act as cardiac precursor label to segregate cells from cardiac/non cardiac origins and traced by magnetic resonance imaging (MRI). Signal regulatory protein alpha (SIRPA) and kinase domain receptor (KDR) recognizing antibodies, form a layer on super param...
Kawaguchi, Koichiro Hashimoto, Michihiro Sugimoto, Masataka
Published in
Biochemical and biophysical research communications
Oxidative stress is one of the major causes of cellular senescence in mammalian cells. The excess amount of reactive oxygen species generated by oxygen metabolism is pathogenic and facilitates tissue aging. Lung tissue is more susceptible to oxidative stress than other organs because it is directly exposed to environmental stresses. The aging of lu...
Lee, Seung Won Moon, Sun Wook Park, Jin Sung Suh, Hye Rim Han, Hee Chul
Published in
Biochemical and biophysical research communications
Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating evidence have revealed that MB d...
Chen, Chen Han, Xu Chen, Cheng Wang, Fenghua Huang, Jinhai Zhang, Lei Wang, Zefang Yang, Haitao
Published in
Biochemical and biophysical research communications
Kato, Koki Ikliptikawati, Dini Kurnia Kobayashi, Akiko Kondo, Hiroya Lim, Keesiang Hazawa, Masaharu Wong, Richard W
Published in
Biochemical and biophysical research communications
The novel human betacoronavirus SARS-CoV-2 has caused an unprecedented pandemic in the 21st century. Several studies have revealed interactions between SARS-CoV-2 viral proteins and host nucleoporins, yet their functions are largely unknown. Here, we demonstrate that the open-reading frame 6 (ORF6) of SARS-CoV-2 can directly manipulate localization...
Takamori, Yukio Ando, Takehiro Fuji, Daisuke Yokoyama, Takumi Yamamoto, Mizuki Kawakami, Takashi
Published in
Biochemical and biophysical research communications
The interaction of the multifunctional cytokine interleukin (IL)-6 and its receptor (IL-6R) is involved in various diseases, including not only autoimmune diseases such as rheumatoid arthritis but also cancer and cytokine storms in coronavirus disease 2019 (COVID-19). In this study, systematic evolution of ligands by exponential enrichment (SELEX) ...
