Cho, Jun-Ho Lee, Young Mok Bae, Seong-Ho Chou, Janice Y
Published in
Biochemical and biophysical research communications
Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of the metabolic disorder glycogen storage disease type Ia (GSD-Ia) deficient in glucose-6-phosphatase-α (G6PC or G6Pase-α). We have shown previously that hepatic G6Pase-α deficiency leads to autophagy impairment, mitochondrial dysfunction, enhanced glycolysis, and augmented hex...
Patel, Neel G. Nguyen, Alyson Xu, Ningyong Ananthasekar, Shivani Alvarez, Diego F. Stevens, Troy Tambe, Dhananjay T.
Published in
Biochemical and biophysical research communications
In the field of endothelial biology, the term “shear forces” is tied to the forces exerted by the flowing blood on the quiescent cells. But endothelial cells themselves also exert physical forces on their immediate and distant neighbors. Specific factors of such intrinsic mechanical signals most relevant to immediate neighbors include normal (Fn) a...
Wang, Yilong Ju, Chenhui Hu, Ji Huang, Kai Yang, Ling
Published in
Biochemical and biophysical research communications
Myocardial infarction due to coronary artery occlusion leads to adverse cardiac remodeling and heart failure. Apoptotic loss of cardiomyocytes near the ischemia area enlarges infarct area and promotes cardiac remodeling. Protein arginine methyltransferase 4 (PRMT4), a type I protein arginine methyltransferase, is involved in many cellular processes...
Hao, Haiyang Lin, Rutao Li, Zhiyuan Shi, Wenshu Huang, Tongtong Niu, Jianqin Han, Jianyong Li, Qiuyan
Published in
Biochemical and biophysical research communications
Melanocortin 4 receptor (MC4R)-deficient mice had been used for several years to study human nonalcoholic steatohepatitis (NASH). However, although liver pathologic and biochemical indicators have been examined, mice models do not always faithfully display the phenotype of the human disease. In this study, we investigated the MC4R knockout phenotyp...
Isozumi, Noriyoshi Ohki, Shinya
Published in
Biochemical and biophysical research communications
Two mGluR7-derived peptides corresponding to residues 856 to 879 and 856 to 875 are known to bind to Ca2+-saturated calmodulin (Ca2+/CaM), and their binding manners are thought to differ. Met872 function is believed as one of the anchor residues for CaM-binding only in the shorter peptide. To uncover the role of Met872 in CaM-binding, we prepared a...
Vyatchin, Ilya G Shevchenko, Ulyana V Shelud'ko, Nikolay S
Published in
Biochemical and biophysical research communications
In the work, we performed densitometry of thick filaments of the Gray's mussel catch muscle; densitometry included determination of electrophoretic dye binding constants of proteins. The results of densitometry showed that the content of twitchin in thick filaments is significantly (10 times) lower than the content of myosin. We performed an in vit...
Shrader, Sarah H. Song, Zhao-Hui
Published in
Biochemical and biophysical research communications
The orphan G protein-coupled receptor 6 (GPR6) is highly expressed in the striatum and1 has been linked to multiple striatal pathologies. The identification of endogenous ligands and their mechanisms of action at GPR6 will help to elucidate the physiological and pathological roles of the receptor. In the current study, we tested the concentration-d...
Beqollari, D Kohrt, W M Bannister, R A
Published in
Biochemical and biophysical research communications
Loss of total muscle force during aging has both atrophic and non-atrophic components. The former deficit is a direct consequence of reduced muscle mass while the latter has been attributed to a depression of excitation-contraction (EC) coupling. It is well established that age-onset reductions in sex hormone production regulate the atrophic compon...
Okubo, Yohei Iino, Masamitsu Hirose, Kenzo
Published in
Biochemical and biophysical research communications
Astrocytes regulate various brain functions, for which Ca2+ release from the endoplasmic reticulum (ER) often play crucial roles. Because astrocytic ER Ca2+ release is robust and frequent, the ER Ca2+ refilling mechanism should be critical for ongoing Ca2+ signaling in astrocytes. In this study, we focused on the putative functional significance of...
Ishihara, Genki Kawamoto, Kosuke Komori, Nobuaki Ishibashi, Toru
Published in
Biochemical and biophysical research communications
Molecular hydrogen (H2) is recognized as a medical gas applicable to numerous diseases including neurodegenerative diseases, metabolic disorders, and rheumatoid arthritis. Although the efficacy of H2 is reportedly attributed to its scavenging capability against the hydroxyl radical, the mechanisms underlying its therapeutic efficacy are not fully u...
