Zhang, Ruixiang Li, Jian Xiang, Manyu Hong, Qinghua Xu, Bin Hu, Wei
Published in
Biochemical and biophysical research communications
Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identified and characterized the zinc...
Zhang, Shufan Wan, Huixuan Wang, Peng Liu, Mengmeng Li, Gongchen Zhang, Chunxue Sun, Yao
Published in
Biochemical and biophysical research communications
Mesenchymal Stem Cells (MSCs) are self-renewing and multipotent stem cells which was investigated for diverse clinical applications. However, complex mechanism of MSCs fate determination is still not fully disclosed. Extracellular matrix (ECM) proteins contribute to maintain MSCs stemness by providing extracellular microenvironment. Increasing evid...
Ray, Sreejana Tillo, Desiree Assad, Nima Ufot, Aniekanabasi Deppmann, Christopher Durell, Stewart R Porollo, Aleksey Vinson, Charles
Published in
Biochemical and biophysical research communications
Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle, which was attributed to a change in binding to methylated DNA sequences. To learn more about the role of this...
Harada, Kazuki Sada, Shoko Sakaguchi, Hidekazu Takizawa, Mai Ishida, Rika Tsuboi, Takashi
Published in
Biochemical and biophysical research communications
S-equol is one of gut bacterial metabolites produced from soybean isoflavone daizein. While S-equol is known to promote glucose-induced insulin secretion from pancreatic β cells, whether S-equol affects glucagon-like peptide-1 (GLP-1) secretion from enteroendoceine L cells remains unclear. Here we assessed the effect of S-equol on GLP-1 secretion f...
Tian, Feng Wang, Jiwei Sun, Haifeng Yang, Jianbo Wang, Peng Wan, Songlin Gao, Xuejin Zhang, Li Li, Jieshou Wang, Xinying
...
Published in
Biochemical and biophysical research communications
Parenteral nutrition (PN) is one of the basic therapies for patients with intestinal failure; however, hepatic steatosis associated with PN limits the long-term use of PN. N-3 polyunsaturated fatty acids (PUFAs) have been used to improve clinical outcomes of patients receiving PN; however, the mechanisms by which n-3 PUFAs ameliorate hepatic steato...
Takizawa, Mai Harada, Kazuki Nakamura, Kazuaki Tsuboi, Takashi
Published in
Biochemical and biophysical research communications
Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+]i) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spontaneous [Ca2+]i increase in as...
Kaneshiro, Nanaka Imaoka, Ryosuke Komai, Masato Kashiyama, Taku Sakurai, Takashi Uehara, Takashi Takasugi, Nobumasa
Published in
Biochemical and biophysical research communications
Amyloid-β precursor protein (APP) correlates with the pathogenesis of certain brain diseases, such as Alzheimer disease (AD). APP is cleaved by several enzymes to produce APP metabolites, including the amyloid beta peptide (Aβ), which accumulates in the brain of AD patients. However, the exact functions of APP metabolites remain elusive. In this st...
Masago, Kayo Kihara, Yasuyuki Yanagida, Keisuke Hamano, Fumie Nakagawa, Shinsuke Niwa, Masami Shimizu, Takao
Published in
Biochemical and biophysical research communications
Cerebral edema is a life-threatening neurological condition characterized by brain swelling due to the accumulation of excess fluid both intracellularly and extracellularly. Fulminant hepatic failure (FHF) develops cerebral edema by disrupting blood-brain barrier (BBB). However, the mechanisms by which mediator induces brain edema in FHF remain to ...
Kublanovsky, Margarita Aharoni, Amir Levy, Dan
Published in
Biochemical and biophysical research communications
Protein lysine methyltransferases (PKMTs) catalyze the methylation of lysine residues on many different cellular proteins. Despite extensive biochemical and structural studies, focusing on PKMT active site-peptide interactions, little is known regarding how PKMTs recognize globular substrates. To examine whether these enzymes recognize protein subs...
Jha, Rajiv Kumar Tare, Priyanka Nagaraja, Valakunja
Published in
Biochemical and biophysical research communications
DNA gyrase introduces negative supercoils into DNA to maintain topological homeostasis. The genes encoding gyrase, gyrB and gyrA, form a dicistronic operon in Mycobacterium tuberculosis (Mtb) and other actinobacteria. Earlier work indicated that DNA relaxation stimulates the expression of the gyr genes, a phenomenon termed relaxation-stimulated tra...
