Chakraborty, Sandipan
Published in
Biochemical and Biophysical Research Communications
The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. The objective of the work is to identify SARS-CoV2 spike variants that emerged during the pandemic and evaluate their binding affinity with ACE2. Evolutionary analysis of 2178 SARS-CoV2 genomes identifies RBD variants that are under selection bia...
Intawong, Kannikar Olson, Debra Chariyalertsak, Suwat
Published in
Biochemical and Biophysical Research Communications
Demands to address the COVID-19 pandemic rapidly surpassed global resources. Successful implementation of application technology resulting in people taking greater control of their own health and medical and public health personnel improving efficiency was requested by authorities in Thailand to reduce the demand on health resources to meet the hea...
Jang, Minsu Park, Rackhyun Park, Yea-In Cha, Yeo-Eun Yamamoto, Ayane Lee, Jin I. Park, Junsoo
Published in
Biochemical and Biophysical Research Communications
Image 1
Duarte, Carolina Akkaoui, Juliet Ho, Anny Garcia, Christopher Yamada, Chiaki Movila, Alexandru
Published in
Biochemical and Biophysical Research Communications
The SARS-CoV-2 virus causes elevated production of senescence-associated secretory phenotype (SASP) markers by macrophages. SARS-CoV-2 enters macrophages through its Spike-protein aided by cathepsin (Cat) B and L, which also mediate SASP production. Since M-CSF and IL-34 control macrophage differentiation, we investigated the age-dependent effects ...
Sakurai, Yasuteru Ngwe Tun, Mya Myat Kurosaki, Yohei Sakura, Takaya Inaoka, Daniel Ken Fujine, Kiyotaka Kita, Kiyoshi Morita, Kouichi Yasuda, Jiro
Published in
Biochemical and Biophysical Research Communications
The current COVID-19 pandemic requires urgent development of effective therapeutics. 5-amino levulinic acid (5-ALA) is a naturally synthesized amino acid and has been used for multiple purposes including as an anticancer therapy and as a dietary supplement due to its high bioavailability. In this study, we demonstrated that 5-ALA treatment potently...
Smits, Veronique A.J. Hernández-Carralero, Esperanza Paz-Cabrera, María Cristina Cabrera, Elisa Hernández-Reyes, Yeray Hernández-Fernaud, Juan Ramón Gillespie, David A. Salido, Eduardo Hernández-Porto, Miriam Freire, Raimundo
...
Published in
Biochemical and Biophysical Research Communications
• COVID-19 patients present a specific immune response against all regions of SARS-CoV-2 N protein. • COVID-19 patients also respond to a fragment containing amino acids 300–685 of the S protein. • Immunoreactivity against other S protein fragments or the M protein is low in COVID-19 patients. • Very few of the control patients display immunoreacti...
Kato, Koki Ikliptikawati, Dini Kurnia Kobayashi, Akiko Kondo, Hiroya Lim, Keesiang Hazawa, Masaharu Wong, Richard W
Published in
Biochemical and biophysical research communications
The novel human betacoronavirus SARS-CoV-2 has caused an unprecedented pandemic in the 21st century. Several studies have revealed interactions between SARS-CoV-2 viral proteins and host nucleoporins, yet their functions are largely unknown. Here, we demonstrate that the open-reading frame 6 (ORF6) of SARS-CoV-2 can directly manipulate localization...
Dang, Mei Li, Yifan Song, Jianxing
Published in
Biochemical and Biophysical Research Communications
• SARS-CoV-2 genomic RNA is packaged with its N protein via phase separation. • Here we discovered that ATP biphasically modulates phase separation of N protein. • ATP also specifically bind the RNA-binding domain of N protein with Kd of 3.3 mM. • ATP is thus critical for uncoating, localizing and packing of the viral genomic RNA. • ATP-Nprotein-RN...
Aldhumani, Ali H. Hossain, Md Ismail Fairchild, Emily A. Boesger, Hannah Marino, Emily C. Myers, Mason Hines, Jennifer V.
Published in
Biochemical and Biophysical Research Communications
• Central core of stem-loop-II motif in SARS-CoV-2 genomic RNA >98% conserved. • Stem-loop II motif RNA conformation altered by mutation present in all SARS-CoV-2. • Ligand-induced structural changes consistent with stem-loop II motif druggability.
Cao, Boqiang Kang, Ting
Published in
Biochemical and Biophysical Research Communications
• A COVID-19 model with media campaigns and treatment is established. • The adaptive control problem of COVID-19 model is proposed. • The controllers are designed by using estimated parameters to reach control goals. • The phenomenon of secondary or even multiple outbreaks of COVID-19 is shown.
