Some effects of fluoride on the IgA protease of the oral bacterium Streptococcus sanguis.
Published in Biochemical Society Transactions
Tyrosine phosphorylation: past, present and future
Published in Biochemical Society Transactions
Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches.
Published in Biochemical Society Transactions
Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are threefold, and result in hindrance of: (i) the generation of the pro-inflammatory peptide C3a, (ii) the generation of opsonin C3b (or its fragment C3d), and (iii) further complement activation of the ...
Multiple roles of arginine/serine-rich splicing factors in RNA processing.
Published in Biochemical Society Transactions
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses s...
Multiple roles of arginine/serine-rich splicing factors in RNA processing.
Published in Biochemical Society Transactions
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses s...
ESR studies of pig citrate synthase.
Published in Biochemical Society Transactions
Vascular zip codes in angiogenesis and metastasis.
Published in Biochemical Society Transactions
In vivo screening of phage-displayed peptide libraries has revealed extensive molecular differences in the blood vessels of individual normal tissues. Pathological lesions also put their signature on the vasculature; in tumours, both blood and lymphatic vessels differ from normal vessels. The changes that characterize tumour blood vessels include s...
ESR studies of pig citrate synthase.
Published in Biochemical Society Transactions
Structure of the 70 S ribosome: implications for movement.
Published in Biochemical Society Transactions
The ribosome is a complex molecular machine, with moving parts, many of which are structural elements of rRNA. We compared the X-ray crystal structures of three different functional states of the 30 S ribosomal subunit - two from crystal structures of the isolated 30 S subunit from the Ramakrishnan group and one from a complex of the 70 S ribosome....
Multiple roles of arginine/serine-rich splicing factors in RNA processing.
Published in Biochemical Society Transactions
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses s...
