Wang, Wenyi Hu, Yue Li, Bohan Wang, Huanan Shen, Jinhua
Published in
Biochemical pharmacology
Global health and economy are deeply influenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its newly emerging variants. Nanobodies with nanometer-scale size are promising for the detection and treatment of SARS-CoV-2 and its variants because they are superior to conventional antibodies in terms of cryptic epitope access...
Yasmeen, Nusrath Selvaraj, Harikrishnan Lakhawat, Sudarshan S Datta, Manali Sharma, Pushpender K Jain, Ajay Khanna, Rakhi Srinivasan, Jayalakshmi Kumar, Vikram
Published in
Biochemical Pharmacology
Fatal “cytokine storms (CS)” observed in critically ill COVID-19 patients are consequences of dysregulated host immune system and over-exuberant inflammatory response. Acute respiratory distress syndrome (ARDS), multi-system organ failure, and eventual death are distinctive symptoms, attributed to higher morbidity and mortality rates among these pa...
Chen, Hongyin Peng, Jiangyun Wang, Tengyao Wen, Jielu Chen, Sifan Huang, Yu Zhang, Yang
Published in
Biochemical pharmacology
Cardiovascular disease is the major cause of mortality and disability, with hypertension being the most prevalent risk factor. Excessive activation of the renin-angiotensin system (RAS) under pathological conditions, leading to vascular remodeling and inflammation, is closely related to cardiovascular dysfunction. The counter-regulatory axis of the...
Aloor, Arya Aradhya, Rajaguru Venugopal, Parvathy Gopalakrishnan Nair, Bipin Suravajhala, Renuka
Published in
Biochemical Pharmacology
Glycan is an essential molecule that controls and drives life in a precise direction. The paucity of research in glycobiology may impede the significance of its role in the pandemic guidelines. The SARS-CoV-2 spike protein is heavily glycosylated, with 22 putative N-glycosylation sites and 17 potential O-glycosylation sites discovered thus far. It ...
Xu, Xiaoying Chen, Yuheng Lu, Xinyu Zhang, Wanlin Fang, Wenxiu Yuan, Luping Wang, Xiaoyan
Published in
Biochemical Pharmacology
The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19 pandemic, bring new waves of infection worldwide. Identification of effective therapeutic drugs to combat the COVID-19 pandemic is an urgent global need. RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication, is the most promising ta...
Huang, Jin Zhou, Chi Deng, Jinniu Zhou, Jianfeng
Published in
Biochemical Pharmacology
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic continues to spread globally. The rapid dispersion of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 drives an urgent need for effective treatments, especially for patients who develop severe pneumonia. The excessive and uncontrolled release of pro-inflammatory cyto...
Hattori, Yuichi Hattori, Kohshi Machida, Takuji Matsuda, Naoyuki
Published in
Biochemical pharmacology
Vascular endothelial cells are major participants in and regulators of immune responses and inflammation. Vascular endotheliitis is regarded as a host immune-inflammatory response of the endothelium forming the inner surface of blood vessels in association with a direct consequence of infectious pathogen invasion. Vascular endotheliitis and consequ...
Parthasarathy, Upasana Martinelli, Roberta Vollmann, Elisabeth H Best, Katharine Therien, Alex G
Published in
Biochemical pharmacology
The host response to SARS-CoV-2, the virus that causes COVID-19, is highly heterogeneous, ranging from mild/asymptomatic to severe. The moderate to severe forms of COVID-19 often require hospitalization, are associated with a high rate of mortality, and appear to be caused by an inappropriately exaggerated inflammatory response to the virus. Emergi...
De Clercq, Erik
Published in
Biochemical pharmacology
Remdesivir (GS-5734, Veklury®) has remained the only antiviral drug formally approved by the US FDA for the treatment of Covid-19 (SARS-CoV-2 infection). Its key structural features are the fact that it is a C-nucleoside (adenosine) analogue, contains a 1'-cyano function, and could be considered as a ProTide based on the presence of a phosphoramida...
Giacomelli, Chiara Piccarducci, Rebecca Marchetti, Laura Romei, Chiara Martini, Claudia
Published in
Biochemical pharmacology
Pulmonary fibrosis (PF) is characterised by several grades of chronic inflammation and collagen deposition in the interalveolar space and is a hallmark of interstitial lung diseases (ILDs). Recently, infectious agents have emerged as driving causes for PF development; however, the role of viral/bacterial infections in the initiation and propagation...
