Liang, Li Shen, Yi Dong, Zhifeng Gu, Xin
Published in
Bioactive materials
Stem cell-derived exosomes (SC-EXO) was an emerging therapeutic agent in regenerative medicine. Intratunical injection of SC-EXO is considered as a prospective approach for erectile dysfunction (ED) treatment. However, high vascularization of cavernous body makes effective retention a major challenge for SC-EXO intratunical injection. In this study...
Ma, Yu-Xuan Jiao, Kai Wan, Qian-Qian Li, Jing Liu, Ming-Yi Zhang, Zi-Bin Qin, Wen Wang, Kai-Yan Wang, Ya-Zhou Tay, Franklin R
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Published in
Bioactive materials
Sensory nerves promote osteogenesis through the release of neuropeptides. However, the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive. The present study identified that new bone formation was more abundantly produced after implantation of silicified collagen...
Xiao, Yun Tian, Jing Wu, Wen-Cheng Gao, Yu-Han Guo, Yu-Xin Song, Sheng-Jiao Gao, Rui Wang, Li-Bin Wu, Xiao-Yu Zhang, Yuan
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Bioactive materials
The lack of targeted and high-efficiency drug delivery to the central nervous system (CNS) nidus is the main problem in the treatment of demyelinating disease. Extracellular vesicles (EVs) possess great promise as a drug delivery vector given their advanced features. However, clinical applications are limited because of their inadequate targeting a...
Li, Zhaonan Tian, Chuan Jiao, Dechao Li, Jing Li, Yahua Zhou, Xueliang Zhao, Huiping Zhao, Yanan Han, Xinwei
Published in
Bioactive materials
Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents. In this work, silver nanoparticles (AgNPs) and cisplatin (DDP) were combined in a synergistic modification strategy to improve the surface function of airway stents. Using polycaprolactone (PCL) as a drug carrier, a dual-functional P...
Fu, Liwei Li, Pinxue Zhu, Junyao Liao, Zhiyao Gao, Cangjian Li, Hao Yang, Zhen Zhao, Tianyuan Chen, Wei Peng, Yu
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Bioactive materials
Many recent studies have shown that joint-resident mesenchymal stem cells (MSCs) play a vital role in articular cartilage (AC) in situ regeneration. Specifically, synovium-derived MSCs (SMSCs), which have strong chondrogenic differentiation potential, may be the main driver of cartilage repair. However, both the insufficient number of MSCs and the ...
Ren, Lanfang Gao, Yang Cheng, Yiyun
Published in
Bioactive materials
Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability. Here, we reported the use of metal-terpyridine based coordinative dendrimer for cytosolic peptide delivery. Among the investigated ...
Liu, Wenjing Luo, Haiyun Wei, Qinwei Liu, Jia Wu, Junrong Zhang, Yanli Chen, Lili Ren, Wencai Shao, Longquan
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Bioactive materials
Graphene oxide (GO) exhibits good mechanical and physicochemical characteristics and has extensive application prospects in bone tissue engineering. However, its effect on angiogenesis is unclear, and its potential toxic effects are heavily disputed. Herein, we found that nanographene oxide (NGO) synthesized by one-step water electrolytic oxidation...
Feng, Qi Li, Dingguo Li, Qingtao Cao, Xiaodong Dong, Hua
Published in
Bioactive materials
Microgel assembly, a macroscopic aggregate formed by bottom-up assembly of microgels, is now emerging as prospective biomaterials for applications in tissue engineering and regenerative medicine (TERM). This mini-review first summarizes the fabrication strategies available for microgel assembly, including chemical reaction, physical reaction, cell-...
Han, Yi Jiang, Lu Shi, Huihui Xu, Chenfang Liu, Minting Li, Qingjian Zheng, Lan Chi, Hong Wang, Mingyue Liu, Zuguo
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Bioactive materials
Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface, which limits their therapeutic effects. Therefore, it is imperative to design...
Chen, Jiaxin Zhu, Haifeng Zhu, Yutao Zhao, Chenchen Wang, Shengyu Zheng, Yixin Xie, Ziang Jin, Yang Song, Honghai Yang, Linjun
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Bioactive materials
Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydroge...
