Mondadori, Carlotta Chandrakar, Amit Lopa, Silvia Wieringa, Paul Talò, Giuseppe Perego, Silvia Lombardi, Giovanni Colombini, Alessandra Moretti, Matteo Moroni, Lorenzo
...
Published in
Bioactive materials
The dual role of macrophages in the healing process depends on macrophage ability to polarize into phenotypes that can propagate inflammation or exert anti-inflammatory and tissue-remodeling functions. Controlling scaffold geometry has been proposed as a strategy to influence macrophage behavior and favor the positive host response to implants. Her...
Ye, Teng Chen, Zhengsheng Zhang, Jieyuan Luo, Lei Gao, Renzhi Gong, Liangzhi Du, Yuhang Xie, Zongping Zhao, Bizeng Li, Qing
...
Published in
Bioactive materials
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance. The therapeutic effect of stem cell derived-small extracellular vesicles (sEVs) for tendinopathy has been validated in recent years. However, whether large extracellular vesicles (lEVs), another subset of extracellular vesicles, possesses the ab...
Su, Yingchao Fu, Jiayin Zhou, Juncen Georgas, Elias Du, Shaokang Qin, Yi-Xian Wang, Yadong Zheng, Yufeng Zhu, Donghui
Published in
Bioactive materials
Zinc (Zn) is a new class of bioresorbable metal that has potential for cardiovascular stent material, orthopedic implants, wound closure devices, etc. However, pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation behavior. Alloying is the most common/effective way to overcome this limitation. Stil...
Cao, Zhicheng Wang, Hongmei Chen, Jialin Zhang, Yanan Mo, Qingyun Zhang, Po Wang, Mingyue Liu, Haoyang Bao, Xueyang Sun, Yuzhi
...
Published in
Bioactive materials
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation. Conventional strategies, such as the control of implant microstructure or the introduction of growth factors, have limited functions failing to manage these co...
Xu, Bingbing Ye, Jing Fan, Bao-Shi Wang, Xinjie Zhang, Ji-Ying Song, Shitang Song, Yifan Jiang, Wen-Bo Wang, Xing Yu, Jia-Kuo
...
Published in
Bioactive materials
Meniscus is a wedge-shaped fibrocartilaginous tissue, playing important roles in maintaining joint stability and function. Meniscus injuries are difficult to heal and frequently progress into structural breakdown, which then leads to osteoarthritis. Regeneration of heterogeneous tissue engineering meniscus (TEM) continues to be a scientific and tra...
Kang, Yong Kong, Na Ou, Meitong Wang, Ying Xiao, Qicai Mei, Lin Liu, Bing Chen, Liqun Zeng, Xiaobin Ji, Xiaoyuan
...
Published in
Bioactive materials
Cancer therapies based on energy conversion, such as photothermal therapy (PTT, light-to-thermal energy conversion) and photodynamic therapy (PDT, light-to-chemical energy conversion) have attracted extensive attention in preclinical research. However, the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied...
Li, Mengna Xu, Jing-Wei Li, Jiayong Wang, Wei Luo, Chenqi Han, Haijie Xu, Zhi-Kang Yao, Ke
Published in
Bioactive materials
Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-related difficulties or other noticeable drawbacks. To p...
Ying, Kangkang Zhu, Yifeng Wan, Jianqin Zhan, Chenyue Wang, Yuchen Xie, Binbin Xu, Peirong Pan, Hongming Wang, Hangxiang
Published in
Bioactive materials
The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various diseases. Numerous synthetic nanoparticles have been developed for pharmaceutical delivery and cancer t...
Wang, Donghui Xing, Shun Peng, Feng Zhang, Xianming Tan, Ji Hao, Xueqing Qiao, Yuqin Ge, Naijian Liu, Xuanyong
Published in
Bioactive materials
Implantable biomaterials are widely used in the curative resection and palliative treatment of various types of cancers. However, cancer residue around the implants usually leads to treatment failure with cancer reoccurrence. Postoperation chemotherapy and radiation therapy are widely applied to clear the residual cancer cells but induce serious si...
Meuwese, Rob T C Versteeg, Elly M M van Drongelen, Joris de Hoog, Daniëlle Bouwhuis, Debora Vandenbussche, Frank P H A van Kuppevelt, Toin H Daamen, Willeke F
Published in
Bioactive materials
Iatrogenic preterm premature rupture of fetal membranes (iPPROM) after fetal surgery remains a strong trigger for premature birth. As fetal membrane defects do not heal spontaneously and amniotic fluid leakage and chorioamniotic membrane separation may occur, we developed a biocompatible, fetoscopically-applicable collagen plug with shape memory to...
