Schipper, Pieter Henckens, Marloes J A G Lopresto, Dora Kozicz, Tamas Homberg, Judith R
Published in
Behavioural brain research
Life stress increases risk for developing post-traumatic stress disorder (PTSD), and more prominently so in short-allele carriers of the serotonin transporter linked polymorphic region (5-HTTLPR). Serotonin transporter knockout (5-HTT-/-) rats show compromised extinction (recall) of conditioned fear, which might mediate the increased risk for PTSD ...
Kader, Farzeen Ghai, Meenu Maharaj, Leah
Published in
Behavioural brain research
DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in development, genomic imprinting, X inactivation, chromosome stability, gene expression and methylation aberrations are involved in an array of human diseases. Methylation at promoters is associated with transcriptional repression, whereas gene body methylation ...
Alexander, Tyler C Simecka, Christy M Kiffer, Frederico Groves, Thomas Anderson, Julie Carr, Hannah Wang, Jing Carter, Gwendolyn Allen, Antiño R
Published in
Behavioural brain research
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer and accounts for 26.8% of cancer diagnoses among children, worldwide-approximately 3000 children each year. While advancements in treating ALL have led to a remission rate of more than 90%, many survivors experience adverse neurocognitive and/or neurobehavioral effects as a r...
Kikusui, Takefumi Kajita, Mayu Otsuka, Natsumi Hattori, Tatsuya Kumazawa, Kanako Watarai, Akiyuki Nagasawa, Miho Inutsuka, Ayumu Yamanaka, Akihiro Matsuo, Naoki
...
Published in
Behavioural brain research
Olfactory signals, including the scent of urine, are thought to be processed by specific brain regions, such as the medial amygdala (Me), and regulate sexual behavior in a sex-dependent manner. We aimed to reveal the sex-specific neural circuit from the accessory olfactory bulb (AOB) to Me by using a transgenic mouse. We quantified the long-lasting...
Green, Amanda Esser, Michael J Perrot, Tara S
Published in
Behavioural brain research
Stressful events during gestation can have sex-specific effects on brain and behaviour, and may contribute to some of the differences observed in adult stress responding and psychopathology. We investigated the impact of a novel repeated prenatal psychological stress (prenatal predator exposure - PPS) during the last week of gestation in rats on of...
Bjånes, David A Moritz, Chet T
Published in
Behavioural brain research
Holten-Rossing, S Slimani, H Ptito, M Danti, S Kupers, R
Published in
Behavioural brain research
We have shown that congenitally blind individuals are more sensitive to painful heat compared to their sighted counterparts. This hypersensitivity might be at least partly mediated by psychological and cognitive factors, such as pain expectation and anxiety. Here we investigate whether uncertainty about the intensity of a pending painful stimulus a...
Dib, Tatiana Martínez-Pinto, Jonathan Reyes-Parada, Miguel Torres, Gonzalo E Sotomayor-Zárate, Ramón
Published in
Behavioural brain research
Research in programming is focused on the study of stimuli that alters sensitive periods in development, such as prenatal and neonatal stages, that can produce long-term deleterious effects. These effects can occur in various organs or tissues such as the brain, affecting brain circuits and related behaviors. Our laboratory has demonstrated that ne...
Lee, Kwang-Wook Kim, Kyungin Kim, Hyoung-Chun Lee, Seok-Yong Jang, Choon-Gon
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Behavioural brain research
Gαq/11 protein transduces signals from neurotransmitter receptors and has been implicated in several functions of the central nervous system. In this study, the role of Gαq/11 protein in methamphetamine (METH)-induced behavioral sensitization was investigated using neurochemical and behavioral approaches. Repeated treatment with METH (2mg/kg, intra...
Ahmed, Heba A Ishrat, Tauheed Pillai, Bindu Bunting, Kristopher M Patel, Ashni Vazdarjanova, Almira Waller, Jennifer L Arbab, Ali S Ergul, Adviye Fagan, Susan C
...
Published in
Behavioural brain research
Growing evidence suggests that renin angiotensin system (RAS) modulators support cognitive function in various animal models. However, little is known about their long-term effects on the brain structure in aged hypertensive animals with chronic cerebral hypoperfusion as well as which specific domains of cognition are most affected. Therefore, in t...
