Home therapy of COVID‐19 at the earliest may greatly prevent hospitalization
Published in Basic & Clinical Pharmacology & Toxicology
Home therapy of COVID‐19 at the earliest may greatly prevent hospitalization
COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?
Published in Basic & Clinical Pharmacology & Toxicology
Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebr...
Published in Basic & Clinical Pharmacology & Toxicology
The Keap1-Nrf2-ARE system serves as a premier defence mechanism to curb oxidative stress, which remains as one of the major causes of ageing and pathogenesis in various diseases. Nrf2 is the principal master regulator of the cellular defence system, and its activation remains the prospective therapeutic approach against chronic diseases. One of the...
Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice.
Published in Basic & clinical pharmacology & toxicology
The purpose of this study was to investigate whether photocatalytic TiO(2) nanoparticles have adjuvant effect, when administered in combination with ovalbumin (OVA) in mice. Mice were immunized via intraperitoneal injections of OVA, OVA + TiO(2) or OVA + Al(OH)(3) and challenged with aerosols of OVA. At the end of the study, serum was analysed for ...
Uptake/Efflux Transport of Tramadol Enantiomers and O -Desmethyl-Tramadol: Focus on P -Glycoprotein
Published in Basic & Clinical Pharmacology & Toxicology
Abstract: The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and (−)-TMD as well as its opioid metabolite (+)- O -desmethyl-tramadol (M1). P -glycoprotein ( P -gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P...
Chronic Pharmacological and Safety Evaluation of Hematide™, a PEGylated Peptidic Erythropoiesis-Stimulating Agent, in Ro...
Published in Basic & Clinical Pharmacology & Toxicology
Hematide™ is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented including rat subchronic and chroni...
Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats.
Published in Basic & clinical pharmacology & toxicology
Sodium azulene sulfonate is a water-soluble derivative of azulene which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium azulene sulfonate is clinically used as a therapeutic agent in the treatment of pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis. There has bee...
