Niwaha, Anxious J Rodgers, Lauren R Greiner, Rosamund Balungi, Priscilla A Mwebaze, Raymond McDonald, Timothy J Hattersley, Andrew T Shields, Beverley M Nyirenda, Moffat J Jones, Angus G
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Published in
BMJ Open Diabetes Research & Care
Introduction The utility of HbA1c (glycosylated hemoglobin) to estimate glycemic control in populations of African and other low-resource countries has been questioned because of high prevalence of other medical conditions that may affect its reliability. Using continuous glucose monitoring (CGM), we aimed to determine the comparative performance o...
Ishimwe, M C Sage Wentzel, Annemarie Shoup, Elyssa M Osei-Tutu, Nana H Hormenu, Thomas Patterson, Arielle C Bagheri, Hadi DuBose, Christopher W Mabundo, Lilian S Ha, Joon
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Published in
BMJ Open Diabetes Research & Care
Introduction Uncertainties exist on whether the main determinant of abnormal glucose tolerance (Abnl-GT) in Africans is β-cell failure or insulin resistance (IR). Therefore, we determined the prevalence, phenotype and characteristics of Abnl-GT due to β-cell failure versus IR in 486 African-born blacks (male: 64%, age: 38±10 years (mean±SD)) living...
Utzschneider, Kristina M Younes, Naji Rasouli, Neda Barzilay, Joshua I Banerji, Mary Ann Cohen, Robert M Gonzalez, Erica V Ismail-Beigi, Faramarz Mather, Kieren J Raskin, Philip
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Published in
BMJ Open Diabetes Research & Care
Introduction The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to det...
Anoop S, Shajith Dasgupta, Riddhi Rebekah, Grace Jose, Arun Inbakumari, Mercy Prem Finney, Geethanjali Thomas, Nihal
Published in
BMJ Open Diabetes Research & Care
Introduction We aimed to compare the predictive accuracy of surrogate indices namely the lipid accumulation product (LAP) index, homeostatic model of assessment of insulin resistance (HOMA-IR), fasting glucose-insulin ratio (FG-IR) and the quantitative-insulin sensitivity check index (QUICKI), against the M value of hyperinsulinemic-euglycemic clam...
Wellens, Martine J Vollenbrock, Charlotte E Dekker, Pim Boesten, Lianne S M Geelhoed-Duijvestijn, Petronella H de Vries-Velraeds, Martine M C Nefs, Giesje Wolffenbuttel, Bruce H R Aanstoot, Henk-Jan van Dijk, Peter R
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Published in
BMJ Open Diabetes Research & Care
Introduction This study aimed to assess the association between fasting serum C-peptide levels and the presence of impaired awareness of hypoglycemia (IAH) in people with type 1 diabetes. Research design and methods We performed a cross-sectional study among 509 individuals with type 1 diabetes (diabetes duration 5–65 years). Extensive clinical dat...
Lameijer, Annel Fokkert, Marion J Edens, Mireille A Gans, Reinold O B Bilo, Henk J G van Dijk, Peter R
Published in
BMJ Open Diabetes Research & Care
Introduction The FreeStyle Libre (FSL) is a flash glucose monitoring (FGM) system. The Flash Monitor Register in the Netherlands (FLARE-NL-4) study previously demonstrated the positive effects of FSL-FGM use during 1 year on glycemic control, quality of life and disease burden among persons with diabetes mellitus (DM). The present follow-up study a...
Liu, Zhiping Jiang, Hong Townsend, Justin H Wang, Jianhua
Published in
BMJ Open Diabetes Research & Care
Introduction To evaluate effects of Ocufolin on retinal microvasculature in mild non-proliferative diabetic retinopathy patients who carried methylenetetrahydrofolate reductase (MTHFR) polymorphisms (DR+MTHFRP). Research design and methods This is a prospective cohort study. Eight DR+MTHFRP (administrated Ocufolin for 6 months) and 15 normal contro...
Zobel, Emilie H Wretlind, Asger Ripa, Rasmus S Rotbain Curovic, Viktor von Scholten, Bernt J Suvitaival, Tommi Hansen, Tine W Kjær, Andreas Legido-Quigley, Cristina Rossing, Peter
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Published in
BMJ open diabetes research & care
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can reduce risk of cardiovascular disease (CVD) in persons living with type 2 diabetes, however the mechanisms explaining this cardiovascular benefit are still debated. We investigated changes in the plasma lipidome following treatment with the GLP-1 RA liraglutide. In a double-bl...
Goff, Louise M Rivas, Carol Moore, Amanda Beckley-Hoelscher, Nicholas Reid, Fiona Harding, Seeromanie
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BMJ open diabetes research & care
Black-British communities are disproportionately affected by type 2 diabetes (T2D). Structured education programs are a core component of T2D healthcare but they are less successful in people from minority ethnic groups. Culturally tailored T2D education has demonstrated greater benefits than usual care. The aim of our study was to evaluate accepta...
Zhou, Qiulun Wang, Ying Gu, Yuqin Li, Jing Wang, Hui Leng, Junhong Li, Weiqin Yu, Zhijie Hu, Gang Ma, Ronald Ching Wan
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Published in
BMJ open diabetes research & care
To investigate associations between genetic variants related to beta-cell (BC) dysfunction or insulin resistance (IR) in type 2 diabetes (T2D) and bile acids (BAs), as well as the risk of gestational diabetes mellitus (GDM). We organized a case-control study of 230 women with GDM and 217 without GDM nested in a large prospective cohort of 22 302 Ch...
