Jia, Yu Li, Dongze You, Yi Yu, Jing Jiang, Wenli Liu, Yi Zeng, Rui Wan, Zhi Lei, Yi Liao, Xiaoyang
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Published in
BMC medicine
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system diseases remains unclear, and the time-dependent sequence of these diseases requires further clarification. After propensity score matching, 163,...
Gao, Hui Zheng, Shuhao Yuan, Xin Xie, Jiarong Xu, Lei
Published in
BMC medicine
The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers. Independent genetic variants strongly associated with IBD were extracted as instrumental variables fr...
Xu, Mingtong Sun, Kan Xu, Wenjie Wang, Chuan Yan, Dewen Li, Shu Cong, Li Pi, Yinzhen Song, Weihong Sun, Qingyuan
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Published in
BMC medicine
Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the findings from a multicenter, randomized, double-blind, placebo-controlled phase 3 clinical trial, which was designed to assess the efficacy and safe...
Zou, Zhuoru Zhang, Lei
Published in
BMC medicine
Lu, Xiaolin Liu, Ruiqi Liao, Yuanyu Cui, Luying Sun, Haoxiu Zhang, Dongzhi Wang, Bojun Fang, Lin Guan, Xin Yao, Yuanfei
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Published in
BMC medicine
Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is limited; the underlined mechanism remains largely elusive. Our study was aimed to find out the resistance mechanism of mTKIs in CRC. RNA seq...
Yan, Ling Li, Yanli Fan, Fengmei Gou, Mengzhuang Xuan, Fangling Feng, Wei Chithanathan, Keerthana Li, Wei Huang, Junchao Li, Hongna
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Published in
BMC medicine
Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrophages contribute to schizophrenia is not well established. We hypothesized that effector molecules expressed in microglia/macrophages were in...
Zhou, Longyuan Zhu, Liguo Wu, Xiaomin Hu, Shixian Zhang, Shenghong Ning, Min Yu, Jun Chen, Minhu
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BMC medicine
Disrupted intestinal epithelial barrier is one of the major causes of Crohn's disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is an adhesion molecule that regulates cell adhesion, migration, and enterocyte differentiation....
Kim, Sooyeon Cho, Juhee Shin, Dong Wook Jeong, Su-Min Kang, Danbee
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BMC medicine
The current guidelines for survivorship in adolescents and young adults (AYA) cancer are based on studies conducted in the United States and European AYA survivors. However, previous studies have shown that the health-related quality of life in cancer survivors can vary depending on race, yet the long-term health differences among AYA survivors by ...
Clark, Rebecca A Weerasuriya, Chathika K Portnoy, Allison Mukandavire, Christinah Quaife, Matthew Bakker, Roel Scarponi, Danny Harris, Rebecca C Rade, Kirankumar Mattoo, Sanjay Kumar
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Published in
BMC medicine
India had an estimated 2.9 million tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01E and BCG-revaccination have recently completed phase IIb trials and estimates of their population-level impact are needed. We estimated the potential health and economic impact ...
Buh, Franklin Chu Hutchinson, Peter J A Anwar, Fahim
Published in
BMC medicine
Traumatic brain injury (TBI) is a global public health challenge, affecting about 69 million individuals annually and being one of the leading causes of mortality. It has adverse consequences in terms of cognitive and physical functioning, which makes rehabilitation interventions an integral part of its management. Early neuro-rehabilitation guidel...
