Bottieau, Emmanuel Van Duffel, Lukas El Safi, Sayda Koirala, Kanika Deshpande Khanal, Basudha Rijal, Suman Bhattarai, Narayan Raj Phe, Thong Lim, Kruy Mukendi, Deby
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Published in
BMC medicine
Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ubiquitous priority (i.e., severe and treatable) infections causing persistent fever in the tropics. In s...
Tong, Tong Qin, Xing Jiang, Yingying Guo, Haiyan Wang, Xiaoning Li, Yan Xie, Fei Lu, Hao Zhai, Peisong Ma, Hailong
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Published in
BMC medicine
Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. RNA sequencing, RT-PCR, and immunoblotting were used to identify differentially exp...
Degnes, Maren-Helene Langeland Westerberg, Ane Cecilie Zucknick, Manuela Powell, Theresa L Jansson, Thomas Henriksen, Tore Roland, Marie Cecilie Paasche Michelsen, Trond Melbye
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BMC medicine
Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown due to the inaccessibility of the human placenta and limitations in assay technologies. We aimed to identify proteins derived from and taken...
Conroy, Andrea L Hawkes, Michael T Leligdowicz, Aleksandra Mufumba, Ivan Starr, Michelle C Zhong, Kathleen Namasopo, Sophie John, Chandy C Opoka, Robert O Kain, Kevin C
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Published in
BMC medicine
Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic significance of BWF and AKI are not well understood. A prospective observational cohort study was conducted to evaluate the association between BWF and AKI in children hospitalize...
Morris, Sarah E Sanislow, Charles A Pacheco, Jenni Vaidyanathan, Uma Gordon, Joshua A Cuthbert, Bruce N
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BMC medicine
In 2013, a few years after the launch of the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative, Cuthbert and Insel published a paper titled "Toward the future of psychiatric diagnosis: the seven pillars of RDoC." The RDoC project is a translational research effort to encourage new ways of studying psychopathology thro...
Zhao, Maoxiang Song, Lulu Zhao, Qianqian Chen, Yating Li, Bin Xie, Zhonghui Fu, Zihao Zhang, Nan Cheng, Xiaowei Li, Xiaoqian
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Published in
BMC medicine
Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of body mass index (BMI) and waist circumference (WC) on the risk...
Adjobimey, Tomabu Meyer, Julia Terkeš, Vedrana Parcina, Marijo Hoerauf, Achim
Published in
BMC medicine
The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary to the predictions, prevalence and mortality due to COVID-19 have remained moderate on the African continent. Several factors, including age, ...
Chen, Li Zhao, Ying Liu, Fangqu Chen, Huimin Tan, Tianqi Yao, Ping Tang, Yuhan
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BMC medicine
Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk factors. This study aims to evaluate the associations of urinary metals with OA risk and the mediated effect of biological aging. Nine urinary...
Lerch, Anita Ten Bosch, Quirine A L'Azou Jackson, Maïna Bettis, Alison A Bernuzzi, Mauro Murphy, Georgina A V Tran, Quan M Huber, John H Siraj, Amir S Bron, Gebbiena M
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Published in
BMC medicine
Despite large outbreaks in humans seeming improbable for a number of zoonotic pathogens, several pose a concern due to their epidemiological characteristics and evolutionary potential. To enable effective responses to these pathogens in the event that they undergo future emergence, the Coalition for Epidemic Preparedness Innovations is advancing th...
Bourguignon, Lucie Tong, Bobo Geisler, Fred Schubert, Martin Röhrich, Frank Saur, Marion Weidner, Norbert Rupp, Rüdiger Kalke, Yorck-Bernhard B Abel, Rainer
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Published in
BMC medicine
The epidemiological international landscape of traumatic spinal cord injury (SCI) has evolved over the last decades along with given inherent differences in acute care and rehabilitation across countries and jurisdictions. However, to what extent these differences may influence neurological and functional recovery as well as the integrity of intern...
