Kim, Honghyok Lee, Jong-Tae Fong, Kelvin C. Bell, Michelle L.
Published in
BMC Medical Research Methodology
BackgroundTime-series analysis with case-only data is a prominent method for the effect of environmental determinants on disease events in environmental epidemiology. In this analysis, adjustment for seasonality and long-term time-trend is crucial to obtain valid findings. When applying this analysis for long-term exposure (e.g., months, years) of ...
Raynaud, Marc Zhang, Huanxi Louis, Kevin Goutaudier, Valentin Wang, Jiali Dubourg, Quentin Wei, Yongcheng Demir, Zeynep Debiais, Charlotte Aubert, Olivier
...
Published in
BMC Medical Research Methodology
BackgroundSince the start of the COVID-19 outbreak, a large number of COVID-19-related papers have been published. However, concerns about the risk of expedited science have been raised. We aimed at reviewing and categorizing COVID-19-related medical research and to critically appraise peer-reviewed original articles.MethodsThe data sources were Pu...
Hubert, Hervé Baert, Valentine Beuscart, Jean-Baptiste Chazard, Emmanuel
Published in
BMC Medical Research Methodology
BackgroundIn most countries, the official statistics for the coronavirus disease 2019 (COVID-19) take account of in-hospital deaths but not those that occur at home. The study’s objective was to introduce a methodology to assess COVID-19 home deaths by analysing the French national out-of-hospital cardiac arrest (OHCA) registry (RéAC).MethodsWe per...
Christensen, Heidi S. Borgbjerg, Jens Børty, Lars Bøgsted, Martin
Published in
BMC Medical Research Methodology
BackgroundTo assess the agreement of continuous measurements between a number of observers, Jones et al. introduced limits of agreement with the mean (LOAM) for multiple observers, representing how much an individual observer can deviate from the mean measurement of all observers. Besides the graphical visualisation of LOAM, suggested by Jones et a...
Zou, Linyi Guo, Hui Berzuini, Carlo
Published in
BMC Medical Research Methodology
BackgroundMendelian randomization (MR) has been widely applied to causal inference in medical research. It uses genetic variants as instrumental variables (IVs) to investigate putative causal relationship between an exposure and an outcome. Traditional MR methods have mainly focussed on a two-sample setting in which IV-exposure association study an...
Mattes, André Roheger, Mandy
Published in
BMC Medical Research Methodology
BackgroundEven though investigating predictors of intervention success (e.g Cognitive Training, CT) is gaining more and more interest in the light of an individualized medicine, results on specific predictors of intervention success in the overall field are mixed and inconsistent due to different and sometimes inappropriate statistical methods used...
Rosychuk, Rhonda J. Bachman, Jeff W.N. Chen, Anqi Hu, X. Joan
Published in
BMC Medical Research Methodology
BackgroundAdministrative databases offer vast amounts of data that provide opportunities for cost-effective insights. They simultaneously pose significant challenges to statistical analysis such as the redaction of data because of privacy policies and the provision of data that may not be at the level of detail required. For example, ages in years ...
Verma, Vivek Mishra, Ashwani Kumar Dhawan, Anju Nath, Dilip C.
Published in
BMC Medical Research Methodology
BackgroundShannon’s index is one of the measures of biodiversity, which is intended to quantify both richness and evenness of the species/individuals in the ecosystem or community. However, application of Shannon’s index in the field of substance use among the street children has not been done till date.MethodsThis paper is concerned with methods o...
Duhazé, Julianne Caubet, Miguel Hässler, Signe Bachelet, Delphine Allez, Matthieu Deisenhammer, Florian Fogdell-Hahn, Anna Gleizes, Aude Hacein-Bey-Abina, Salima Mariette, Xavier
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Published in
BMC Medical Research Methodology
BackgroundWith the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the novel production of antibodies from B-cell clones by a fraction of the exposed subjects. Identifying g...
Pate, Alexander van Staa, Tjeerd Emsley, Richard
Published in
BMC Medical Research Methodology
BackgroundA downwards secular trend in the incidence of cardiovascular disease (CVD) in England was identified through previous work and the literature. Risk prediction models for primary prevention of CVD do not model this secular trend, this could result in over prediction of risk for individuals in the present day. We evaluate the effects of mod...
