Gao, Jie Li, Yan Liu, Zijin Wang, Dong Zhang, Huawu
Published in
BMC Molecular and Cell Biology
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown. The aim of this study is to investigate the effect of acetaminophen on inflammation and extracellular matrix degradation in human chondrocytes, and the possible molecular mechanisms involved ...
Xin, Wenhu Zhang, Jian Zhang, Haibin Ma, Xueyao Zhang, Yunzhong Li, Yufeng Wang, Fang
Published in
BMC Molecular and Cell Biology
Cervical cancer is an important malignant tumor threatening the physical and mental health of women in the world. As a new calcium activated chloride channel protein, calcium activated chloride channel ( CLCA2 ) plays an important role in tumorigenesis and development. But its role and exact regulatory mechanism in cervical cancer are still unclear...
Liu, Yang Niu, Pingping Zhou, Mengqi Xue, Hui
Published in
BMC Molecular and Cell Biology
Background The cranial region is a complex set of blood vessels, cartilage, nerves and soft tissues. The reconstruction of cranial defects caused by trauma, congenital defects and surgical procedures presents clinical challenges. Our previous data showed that deficiency of the proteoglycan (PG) form of dentin matrix protein 1 (DMP1-PG) could lead t...
Zhu, Zemin Zhao, Zhijian Chen, Xun Chu, Zhou He, Yi Tan, Yingzheng Zhou, Juan Tang, Caixi
Published in
BMC Molecular and Cell Biology
Background COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth hormone (GH)/estrogen/androgen in normal human lung epithelial BEAS-2B cells on COVID-19-type proinflammatory responses. Methods A BEAS-2B COVID-19-like proinflammatory cell model was constructed. Aft...
Aly, Riham M. Aglan, Hadeer A. Eldeen, Ghada Nour Ahmed, Hanaa H.
Published in
BMC Molecular and Cell Biology
Background Despite the recent progress in the differentiation strategies of stem cells into pancreatic beta cell lineage, current protocols are not optimized for different cell types. The purpose of this study is to investigate and compare the ability of stem cells derived from dental pulp (DPSCs) and periodontal ligament (PDLSCs) as two anatomical...
Mansourabadi, Amir Hossein Aghamajidi, Azin Faraji, Fatemeh Taghizadeh, Shirin Mohamed Khosroshahi, Leila Bahramkiya, Mona Azimi, Maryam
Published in
BMC Molecular and Cell Biology
Background Aquaporins are channel proteins, form pores in the membrane of biological cells to facilitate the transcellular and transepithelial water movement. The role of Aquaporins in carcinogenesis has become an area of interest. In this study, we aimed to investigate the effects of adipose-derived mesenchymal stem cells secreted exosomes on the ...
Mirzadeh, Abolfazl Kobakhidze, George Vuillemot, Rémi Jonic, Slavica Rouiller, Isabelle
Published in
BMC Molecular and Cell Biology
Background The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events and organelle biogenesis during mitosis in which it acts in concert with cofactors p47 and p37. Cofactors assist p97 in extracting a...
Chen, Hao Li, Chunlin Hu, Haiyang Zhang, Bin
Published in
BMC molecular and cell biology
Glioblastoma (GBM) represents nearly one-half of primary brain tumors, and the median survival of patients with GBM is only 14.6 months. Surgery followed by radiation with concomitant temozolomide (TMZ) therapy is currently the standard of care. However, an increasing body of evidence suggests that GBM acquires resistance to TMZ, compromising the e...
He, Yanan Wang, J. Jiang, Xinyan Gao, Jianhua Cheng, Yan Liang, Tian Zhou, Jun Sun, Liyuan Zhang, Guangmei
Published in
BMC Molecular and Cell Biology
Background Endometriosis is one of the most common gynecological diseases, and seriously reduces the quality of life of patients. However, the pathogenesis of this disease is unclear. Therefore, more studies are needed to elucidate its pathogenesis. Our previous publication found that the Sonic Hedgehog (SHH) signaling pathway was activated in endo...
Nuiyen, Aussanee Rattanasri, Araya Wipa, Piyamaporn Roytrakul, Sittiruk Wangteeraprasert, Apirath Pongcharoen, Sutatip Ngoenkam, Jutaporn
Published in
BMC Molecular and Cell Biology
Background The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell receptor signalling as well as actin polymerisation. However, the role of Nck1 in the lipid metabolism in T cells is unknown. In the present study, we investigated t...
