Klatte, Tobias Gallagher, Kevin M. Afferi, Luca Volpe, Alessandro Kroeger, Nils Ribback, Silvia McNeill, Alan Riddick, Antony C. P. Armitage, James N. ‘Aho, Tevita F.
...
Published in
BMC Medicine
BackgroundThe current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as the same disease, simply because they occur in the same organ. Specifically, there is a paucity of tools to risk-stratify patients w...
Zucchelli, Alberto Vetrano, Davide L. Grande, Giulia Calderón-Larrañaga, Amaia Fratiglioni, Laura Marengoni, Alessandra Rizzuto, Debora
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BMC Medicine
BackgroundThe identification of individuals at increased risk of poor health-related outcomes is a priority. Geriatric research has proposed several indicators shown to be associated with these outcomes, but a head-to-head comparison of their predictive accuracy is still lacking. We therefore aimed to compare the accuracy of five geriatric health i...
Rigoli, Felix Mascarenhas, Sergio Alves, Domingos Canelas, Tiago Duarte, Geraldo
Published in
BMC Medicine
BackgroundThe healthcare system can be understood as the dynamic result of the interaction of hospitals, patients, providers, and government configuring a complex network of reciprocal influences. In order to better understand such a complex system, the analysis must include characteristics that are feasible to be studied in order to redesign its f...
Leslie, R. David Vartak, Tanwi
Published in
BMC Medicine
Wilson-Jones, Megan Smith, Kyla Jones, Dan Hamilton, Helen Richardson, Leah Macintyre, Alison Gautam, Om Prasad Harvey, Erik Northover, Henry
Published in
BMC Medicine
Please see related article: https://doi.org/10.1186/s12916-019-1410-x
Funk, Sebastian Knapp, Jennifer K. Lebo, Emmaculate Reef, Susan E. Dabbagh, Alya J. Kretsinger, Katrina Jit, Mark Edmunds, W. John Strebel, Peter M.
Published in
BMC Medicine
BackgroundVaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipulated at 90–95%. This figure does...
His, Mathilde Viallon, Vivian Dossus, Laure Gicquiau, Audrey Achaintre, David Scalbert, Augustin Ferrari, Pietro Romieu, Isabelle Onland-Moret, N. Charlotte Weiderpass, Elisabete
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Published in
BMC Medicine
BackgroundMetabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk.MethodsA nested case-control study was established within the European Prospective Investigation int...
Lawlor, Deborah A.
Published in
BMC Medicine
BMC Medicine was launched in November 2003 as an open access, open peer-reviewed general medical journal that has a broad remit to publish “outstanding and influential research in all areas of clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedica...
Schnall, Jesse Rajkhowa, Arjun Ikuta, Kevin Rao, Puja Moore, Catrin E.
Published in
BMC Medicine
Fountoulakis, Nikolaos Wijesuriya, Mahen Gnudi, Luigi Gulliford, Martin Karalliedde, Janaka
Published in
BMC Medicine
BackgroundWe have previously demonstrated in the DIABRISK-SL trial that a trimonthly pragmatic lifestyle modification (P-LSM), as compared to a 12-monthly LSM advice (C-LSM), significantly reduced the primary composite endpoint of predictors of cardio-metabolic disease (new onset type 2 diabetes (T2DM), hypertension, impaired glucose tolerance (IGT...
