Weerasuriya, Chathika K Harris, Rebecca C McQuaid, C Finn Bozzani, Fiammetta Ruan, Yunzhou Li, Renzhong Li, Tao Rade, Kirankumar Rao, Raghuram Ginsberg, Ann M
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Published in
BMC Medicine
Background Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic prevention of disease TB vaccines ...
Ho, Kuo-Hao Huang, Tzu-Wen Shih, Chwen-Ming Lee, Yi-Ting Liu, Ann-Jeng Chen, Peng-Hsu Chen, Ku-Chung
Published in
BMC Medicine
Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism. However, glycolysis-associated lncRNA signatures and their clinical relevance in cancers remain unclear. We investigated the roles of glycolysis-associated lncRNAs in can...
Quinn, Terence J. Burton, Jennifer K. Carter, Ben Cooper, Nicola Dwan, Kerry Field, Ryan Freeman, Suzanne C. Geue, Claudia Hsieh, Ping-Hsuan McGill, Kris
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Published in
BMC Medicine
Background Following the initial identification of the 2019 coronavirus disease (covid-19), the subsequent months saw substantial increases in published biomedical research. Concerns have been raised in both scientific and lay press around the quality of some of this research. We assessed clinical research from major clinical journals, comparing me...
Chen, Ling-Wei Aubert, Adrien M. Shivappa, Nitin Bernard, Jonathan Y. Mensink-Bout, Sara M. Geraghty, Aisling A. Mehegan, John Suderman, Matthew Polanska, Kinga Hanke, Wojciech
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Published in
BMC Medicine
Background Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We investigated whether maternal whole diet quality and inflammatory potential influence childhood adiposity. Methods We harmonized and poo...
McKeigue, Paul M. Kennedy, Sharon Weir, Amanda Bishop, Jen McGurnaghan, Stuart J. McAllister, David Robertson, Chris Wood, Rachael Lone, Nazir Murray, Janet
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Published in
BMC Medicine
Background The objective of this study was to investigate the relation of severe COVID-19 to prior drug prescribing. Methods Severe cases were defined by entry to critical care or fatal outcome. For this matched case-control study (REACT-SCOT), all 4251 cases of severe COVID-19 in Scotland since the start of the epidemic were matched for age, sex a...
Neven, Kristof Y. Cox, Bianca Cosemans, Charlotte Gyselaers, Wilfried Penders, Joris Plusquin, Michelle Roels, Harry A. Vrijens, Karen Ruttens, Ann Nawrot, Tim S.
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Published in
BMC Medicine
Background The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects short-term iodine intake, to gestational diabetes mellitus (GDM) is inconclusive. Although the placental concentrations would bet...
Jarvis, Christopher I. Gimma, Amy van Zandvoort, Kevin Wong, Kerry L. M. Abbas, Kaja Villabona-Arenas, C. Julian O’Reilly, Kathleen Quaife, Matthew Rosello, Alicia Kucharski, Adam J.
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Published in
BMC Medicine
Background England’s COVID-19 response transitioned from a national lockdown to localised interventions. In response to rising cases, these were supplemented by national restrictions on contacts (the Rule of Six), then 10 pm closing for bars and restaurants, and encouragement to work from home. These were quickly followed by a 3-tier system applyin...
Liang, Weihao Wu, Yuzhong Xue, Ruicong Wu, Zexuan Wu, Dexi He, Jiangui Dong, Yugang Lip, Gregory Y. H. Zhu, Wengen Liu, Chen
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Published in
BMC Medicine
Background The C2HEST score has been validated for predicting AF in the general population or post-stroke patients. We aimed to assess whether this risk score could predict incident AF and other clinical outcomes in heart failure with preserved ejection fraction (HFpEF) patients. Methods A total of 2202 HFpEF patients without baseline AF in the TOP...
Guldiken, Nurdan Argemi, Josepmaria Gurbuz, Berivan Atkinson, Stephen R. Oliverius, Martin Fila, Petr Hamesch, Karim Bruns, Tony Cabezas, Joaquín Lozano, Juan J.
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Published in
BMC Medicine
Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions. The aim of this study was to explore whether serum transferrin reflects HNF4α activity. Methods Factors regulating transferrin expression in alco...
Lokuge, K. Banks, E. Davis, S. Roberts, L. Street, T. O’Donovan, D. Caleo, G. Glass, K.
Published in
BMC Medicine
Background Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strategy to detect remaining COVID-19 community cases through exhaustive identification of every active transmission chain. We identifie...
