Sun, Yiting Duan, Jianchun Fang, Wenfeng Wang, Zhijie Du, Xinyang Wang, Xin Li, Chengcheng Cai, Shangli Zhao, Jie Li, Sini
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Published in
BMC Medicine
Background With the revolutionary progress of immune checkpoint inhibitors (ICIs) achieved in non-small cell lung cancers (NSCLC), identifying patients benefiting from ICIs becomes critical and urgent. The associations of genomic alterations in protein tyrosine phosphatase receptor-type (PTPRs) and ICIs responses are unknown. Methods Whole-exome se...
Fernández-Bañares, Fernando López-Palacios, Natalia Corzo, María Arau, Beatriz Rubio, Mercedes Fernández-Prieto, Marta Tristán, Eva Pujals, Mar Farrais, Sergio Horta, Saúl
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Published in
BMC Medicine
Background The diagnosis of coeliac disease (CD) in individuals that have started a gluten-free diet (GFD) without an adequate previous diagnostic work-out is a challenge. Several immunological assays such as IFN-γ ELISPOT have been developed to avoid the need of prolonged gluten challenge to induce the intestinal damage. We aimed to evaluate the d...
Unger, Holger W. Laurita Longo, Valentina Bleicher, Andie Ome-Kaius, Maria Karl, Stephan Simpson, Julie A. Karahalios, Amalia Aitken, Elizabeth H. Rogerson, Stephen J.
Published in
BMC Medicine
Background Iron deficiency (ID) has been associated with adverse pregnancy outcomes, maternal anaemia, and altered susceptibility to infection. In Papua New Guinea (PNG), monthly treatment with sulphadoxine-pyrimethamine plus azithromycin (SPAZ) prevented low birthweight (LBW;
Quaife, Matthew Li, Shuai
Published in
BMC Medicine
Farinholt, Timothy Doddapaneni, Harsha Qin, Xiang Menon, Vipin Meng, Qingchang Metcalf, Ginger Chao, Hsu Gingras, Marie-Claude Avadhanula, Vasanthi Farinholt, Paige
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Published in
BMC Medicine
Background This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health. Methods Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 (severe acute respiratory syndrome coro...
Zhao, Shen Zhang, Zhonghan Zhan, Jianhua Zhao, Xin Chen, Xinru Xiao, Liyun Wu, Kui Ma, Yuxiang Li, Mengzhen Yang, Yunpeng
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Published in
BMC Medicine
Background With the identification of new targetable drivers and the recent emergence of novel targeted drugs, using comprehensive genomic profiling in lieu of the routine testing for classic drivers in the clinical care for advanced NSCLC has been increasingly advocated. However, the key assumption justifying this practice, that comprehensive geno...
Biggs, Joseph R. Sy, Ava Kristy Sherratt, Katharine Brady, Oliver J. Kucharski, Adam J. Funk, Sebastian Reyes, Mary Anne Joy Quinones, Mary Ann Jones-Warner, William Avelino, Ferchito L.
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Published in
BMC Medicine
Background Stratifying dengue risk within endemic countries is crucial for allocating limited control interventions. Current methods of monitoring dengue transmission intensity rely on potentially inaccurate incidence estimates. We investigated whether incidence or alternate metrics obtained from standard, or laboratory, surveillance operations rep...
Hjorth, Cathrine Fonnesbech Damkier, Per Ejlertsen, Bent Lash, Timothy Sørensen, Henrik Toft Cronin-Fenton, Deirdre
Published in
BMC Medicine
Background To investigate how socioeconomic position (SEP) influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients in terms of breast cancer recurrence and mortality. Methods We conducted a cohort study nested in the ProBeCaRe (Predictors of Breast Cancer Recurrence) cohort ( n = 5959). We identified all pr...
Verelst, Frederik Hermans, Lisa Vercruysse, Sarah Gimma, Amy Coletti, Pietro Backer, Jantien A. Wong, Kerry L. M. Wambua, James van Zandvoort, Kevin Willem, Lander
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Published in
BMC Medicine
Background SARS-CoV-2 dynamics are driven by human behaviour. Social contact data are of utmost importance in the context of transmission models of close-contact infections. Methods Using online representative panels of adults reporting on their own behaviour as well as parents reporting on the behaviour of one of their children, we collect contact...
Nilson, Eduardo Augusto Fernandes Pearson-Stuttard, Jonathan Collins, Brendan Guzman-Castillo, Maria Capewell, Simon O’Flaherty, Martin Jaime, Patrícia Constante Kypridemos, Chris
Published in
BMC Medicine
Background Excessive sodium consumption is one of the leading dietary risk factors for non-communicable diseases, including cardiovascular disease (CVD), mediated by high blood pressure. Brazil has implemented voluntary sodium reduction targets with food industries since 2011. This study aimed to analyse the potential health and economic impact of ...
