Bottieau, Emmanuel Van Duffel, Lukas El Safi, Sayda Koirala, Kanika Deshpande Khanal, Basudha Rijal, Suman Bhattarai, Narayan Raj Phe, Thong Lim, Kruy Mukendi, Deby
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Published in
BMC medicine
Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ubiquitous priority (i.e., severe and treatable) infections causing persistent fever in the tropics. In s...
Mansoor, Rashid Commons, Robert J. Douglas, Nicholas M. Abuaku, Benjamin Achan, Jane Adam, Ishag Adjei, George O. Adjuik, Martin Alemayehu, Bereket H. Allan, Richard
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Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods Individual patient data from eligible antimalar...
Gautheron, Jérémie Lima, Lara Akinci, Baris Zammouri, Jamila Auclair, Martine Ucar, Sema Kalkan Ozen, Samim Altay, Canan Bax, Bridget E. Nemazanyy, Ivan
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Published in
BMC Medicine
Background Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyuridine, to thymine and uracil. Biallelic TYMP variants are responsible for Mitochondrial NeuroGastroIntestinal Encephalomyopathy (...
Colomier, Esther Melchior, Chloé Algera, Joost P. Hreinsson, Jóhann P. Störsrud, Stine Törnblom, Hans Van Oudenhove, Lukas Palsson, Olafur S. Bangdiwala, Shrikant I. Sperber, Ami D.
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Published in
BMC Medicine
Background Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain a...
Zhang, Chengcheng Qin, Fengqin Li, Xiaojing Du, Xiangdong Li, Tao
Published in
BMC Medicine
Background Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analytical pipeline to efficiently transform genetic associations to identify novel proteins for lacunar stroke. Methods We systematical...
Guo, Ping Gong, Weiming Li, Yuanming Liu, Lu Yan, Ran Wang, Yanjun Zhang, Yanan Yuan, Zhongshang
Published in
BMC Medicine
Background The current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In addition, the genetic determinants underlying LBD and the shared genetic etiology with Alzheimer’s disease (AD) and Parkinson’s disease (PD) remain poorly understood. Methods Using the largest GWAS summary ...
Schwalm, J. D. Ivers, Noah M. Bouck, Zachary Taljaard, Monica Natarajan, Madhu K. Nguyen, Francis Hijazi, Waseem Thavorn, Kednapa Dolovich, Lisa McCready, Tara
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Published in
BMC Medicine
Background Preliminary evidence suggests that providing longer duration prescriptions at discharge may improve long-term adherence to secondary preventative cardiac medications among post-myocardial infarction (MI) patients. We implemented and assessed the effects of two hospital-based interventions—(1) standardized prolonged discharge prescription...
Blankenberger, Jacob Kaufmann, Marco Albanese, Emiliano Amati, Rebecca Anker, Daniela Camerini, Anne-Linda Chocano-Bedoya, Patricia Cullati, Stéphane Cusini, Alexia Fehr, Jan
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Published in
BMC Medicine
Background We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association. Methods SARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and F...
Li, Chao Chen, Kangyu Shi, Guoshuai Shi, Rui Wu, Zhenqiang Yuan, Xiaodan Watson, Vicky Jiang, Zhixin Mai, Hui Yang, Tian
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Published in
BMC Medicine
Background Recent guidelines recommended a systolic blood pressure (SBP) target of
Chen, Li Zhao, Ying Liu, Fangqu Chen, Huimin Tan, Tianqi Yao, Ping Tang, Yuhan
Published in
BMC medicine
Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk factors. This study aims to evaluate the associations of urinary metals with OA risk and the mediated effect of biological aging. Nine urinary...
