Ferreira, João Pedro Mehta, Cyrus Sharma, Abhinav Nissen, Steven E. Rossignol, Patrick Zannad, Faiez
Published in
BMC Medicine
BackgroundThe EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because alogliptin is cleared by the kidney, patients were stratified according to screening renal function within two independently rando...
Domenech de Cellès, Matthieu Campbell, Helen Borrow, Ray Taha, Muhamed-Kheir Opatowski, Lulla
Published in
BMC Medicine
BackgroundThe recent emergence of strains belonging to the meningococcal serogroup W (MenW) sequence type-11 clonal complex and descending from the South American sub-lineage (MenW:cc11/SA) has caused significant shifts in the epidemiology of meningococcal disease worldwide. Although MenW:cc11/SA is deemed highly transmissible and invasive, its epi...
Naidoo, Nivantha Nguyen, Van Thu Ravaud, Philippe Young, Bridget Amiel, Philippe Schanté, Daniel Clarke, Mike Boutron, Isabelle
Published in
BMC Medicine
BackgroundParticipation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT.MethodsWe conducted a systematic review of qualit...
Houchen, Courtney W. Li, Min
Published in
BMC Medicine
Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunotherapy have failed in pancreatic cancer. Understanding the underlying mechanism that drives immune evasion of pancreatic cancer is critical f...
Verhagen, Mark D. Brazel, David M. Dowd, Jennifer Beam Kashnitsky, Ilya Mills, Melinda C.
Published in
BMC Medicine
BackgroundCOVID-19 poses one of the most profound public health crises for a hundred years. As of mid-May 2020, across the world, almost 300,000 deaths and over 4 million confirmed cases were registered. Reaching over 30,000 deaths by early May, the UK had the highest number of recorded deaths in Europe, second in the world only to the USA. Hospita...
Ioannidis, Konstantinos Askelund, Adrian Dahl Kievit, Rogier A. van Harmelen, Anne-Laura
Published in
BMC Medicine
An amendment to this paper has been published and can be accessed via the original article.
Xu, Wei He, Yazhou Wang, Yuming Li, Xue Young, Jane Ioannidis, John P. A. Dunlop, Malcolm G. Theodoratou, Evropi
Published in
BMC Medicine
BackgroundThere is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such variables.MethodsWe conducted an umbrella review of all systematic reviews of observational studies (with/without meta-analysis) th...
Kohler, Jillian C. Mackey, Tim K.
Published in
BMC Medicine
Bagdasarian, N. Cross, G. B. Fisher, D.
Published in
BMC Medicine
BackgroundPreprint manuscripts, rapid publications and opinion pieces have been essential in permitting the lay press and public health authorities to preview data relating to coronavirus disease 2019 (COVID-19), including the range of clinical manifestations and the basic epidemiology early on in the pandemic. However, the rapid dissemination of i...
Brill, Simon E. Jarvis, Hannah C. Ozcan, Ezgi Burns, Thomas L. P. Warraich, Rabia A. Amani, Lisa J. Jaffer, Amina Paget, Stephanie Sivaramakrishnan, Anand Creer, Dean D.
...
Published in
BMC Medicine
BackgroundData from the UK COVID-19 outbreak are emerging, and there are ongoing concerns about a disproportionate effect on ethnic minorities. There is very limited information on COVID-19 in the over-80s, and the rates of hospital-onset infections are unknown.MethodsThis was a retrospective cohort study from electronic case records of the first 4...
