Conduct and reporting of individual participant data network meta-analyses need improvement
Published in BMC Medicine
Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the E...
Published in BMC Medicine
BackgroundThe EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because alogliptin is cleared by the kidney, patients were stratified according to screening renal function within two independently rando...
Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American str...
Published in BMC Medicine
BackgroundThe recent emergence of strains belonging to the meningococcal serogroup W (MenW) sequence type-11 clonal complex and descending from the South American sub-lineage (MenW:cc11/SA) has caused significant shifts in the epidemiology of meningococcal disease worldwide. Although MenW:cc11/SA is deemed highly transmissible and invasive, its epi...
The research burden of randomized controlled trial participation: a systematic thematic synthesis of qualitative evidenc...
Published in BMC Medicine
BackgroundParticipation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT.MethodsWe conducted a systematic review of qualit...
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
Published in BMC Medicine
BackgroundPotential routes whereby systemic inflammation, oxidative stress and mitochondrial dysfunction may drive the development of endothelial dysfunction and atherosclerosis, even in an environment of low cholesterol, are examined.Main textKey molecular players involved in the regulation of endothelial cell function are described, including PEC...
Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-b...
...Published in BMC Medicine
BackgroundThe coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes.MethodWe conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China. All p...
A machine learning analysis of a “normal-like” IDH-WT diffuse glioma transcriptomic subgroup associated with prolonged s...
Published in BMC Medicine
BackgroundClassification of primary central nervous system tumors according to the World Health Organization guidelines follows the integration of histologic interpretation with molecular information and aims at providing the most precise prognosis and optimal patient management. According to the cIMPACT-NOW update 3, diffuse isocitrate dehydrogena...
Adapting hospital capacity to meet changing demands during the COVID-19 pandemic
...Published in BMC Medicine
BackgroundTo calculate hospital surge capacity, achieved via hospital provision interventions implemented for the emergency treatment of coronavirus disease 2019 (COVID-19) and other patients through March to May 2020; to evaluate the conditions for admitting patients for elective surgery under varying admission levels of COVID-19 patients.MethodsW...
Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway
...Published in BMC Medicine
BackgroundChildhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.MethodsParticipants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry...
Early warning signals in psychopathology: what do they tell?
...Published in BMC Medicine
BackgroundDespite the increasing understanding of factors that might underlie psychiatric disorders, prospectively detecting shifts from a healthy towards a symptomatic state has remained unattainable. A complex systems perspective on psychopathology implies that such symptom shifts may be foreseen by generic indicators of instability, or early war...
