Lefort, M Sharmin, S Andersen, J B Vukusic, S Casey, R Debouverie, M Edan, G Ciron, J Ruet, A De Sèze, J
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Published in
BMC medical research methodology
Natalizumab and fingolimod are used as high-efficacy treatments in relapsing-remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different methods to control treatment indication bias and manage censoring. The objective of this empirical study was to elucidate the impact of method...
Sarkies, Mitchell N. Francis-Auton, Emilie Long, Janet C. Pomare, Chiara Hardwick, Rebecca Braithwaite, Jeffrey
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BMC Medical Research Methodology
Implementation science in healthcare aims to understand how to get evidence into practice. Once this is achieved in one setting, it becomes increasingly difficult to replicate elsewhere. The problem is often attributed to differences in context that influence how and whether implementation strategies work. We argue that realist research paradigms p...
Sullivan, Edith V. Thompson, Wesley K. Brumback, Ty Prouty, Devin Tapert, Susan F. Brown, Sandra A. De Bellis, Michael D. Nooner, Kate B. Baker, Fiona C. Colrain, Ian M.
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Published in
BMC Medical Research Methodology
Background Accurate measurement of trajectories in longitudinal studies, considered the gold standard method for tracking functional growth during adolescence, decline in aging, and change after head injury, is subject to confounding by testing experience. Methods We measured change in cognitive and motor abilities over four test sessions (baseline...
Smith, Aiden Lambert, Paul C. Rutherford, Mark J.
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BMC Medical Research Methodology
Background A lack of available data and statistical code being published alongside journal articles provides a significant barrier to open scientific discourse, and reproducibility of research. Information governance restrictions inhibit the active dissemination of individual level data to accompany published manuscripts. Realistic, high-fidelity t...
Lamarche, Larkin Clark, Rebecca E. Parascandalo, Fiona Mangin, Dee
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BMC Medical Research Methodology
Background Normalization process theory (NPT) has been widely used to better understand how new interventions are implemented and embedded. The NoMAD (Normalization Measurement Development questionnaire) is a 23-item NPT instrument based on NPT. As the NoMAD is a relatively new instrument, the objectives of this paper are: to describe the experienc...
Soogun, Adenike O. Kharsany, Ayesha B. M. Zewotir, Temesgen North, Delia Ogunsakin, Ropo Ebenezer
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BMC Medical Research Methodology
Background Sustainable Human Immunodeficiency Virus (HIV) virological suppression is crucial to achieving the Joint United Nations Programme of HIV/AIDS (UNAIDS) 95–95-95 treatment targets to reduce the risk of onward HIV transmission. Exploratory data analysis is an integral part of statistical analysis which aids variable selection from complex s...
Fidahic, Mahir Nujic, Danijela Civljak, Marta Runjic, Renata Markotic, Filipa Vidak, Marin Puljak, Livia
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BMC Medical Research Methodology
Background The concept of standard of care (SoC) treatment is commonly utilized in clinical trials. However, in a setting of an emergent disease, such as COVID-19, where there is no established effective treatment, it is unclear what the investigators considered as the SoC in early clinical trials. The aim of this study was to analyze and classify ...
Arayeshgari, Mahya Roshanaei, Ghodratollah Ghaleiha, Ali Poorolajal, Jalal Tapak, Leili
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BMC medical research methodology
Schizophrenia is a chronic, severe, and debilitating mental disorder always considered one of the recurrent psychiatric diseases. This study aimed to use penalized count regression models to determine factors associated with the number of rehospitalizations of schizophrenia disorder. This retrospective cohort study was performed on 413 schizophreni...
Wang, Huan Song, Jinlu Lin, Yali Dai, Wenjie Gao, Yinyan Qin, Lang Chen, Yancong Tam, Wilson Wu, Irene Xy Chung, Vincent Ch
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BMC medical research methodology
To summarize the up-to-date empirical evidence on trial-level characteristics of randomized controlled trials associated with treatment effect estimates. A systematic review searched three databases up to August 2020. Meta-epidemiological (ME) studies of randomized controlled trials on intervention effect were eligible. We assessed the methodologic...
Garg, Ravi Mickenautsch, Steffen
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BMC medical research methodology
The NINDS rt-PA Stroke Study is frequently cited in support of alteplase for acute ischemic stroke within 3 h of symptom onset. Multiple post-hoc reanalyses of this trial have been published to adjust for a baseline imbalance in stroke severity. We performed a risk of selection bias assessment and reanalyzed trial data to determine if the etiology ...
