Xian, Tew Hui Sinniah, Kurunathan Yean, Chan Yean Krishnamoorthy, Venkateskumar Bahari, Mohd Baidi Ravichandran, Manickam Prabhakaran, Guruswamy
Published in
BMC Immunology
BackgroundCholera, an acute watery diarrhoeal disease caused by Vibrio cholerae serogroup O1 and O139 across the continents. Replacing the existing WHO licensed killed multiple-dose oral cholera vaccines that demand ‘cold chain supply’ at 2–8 °C with a live, single-dose and cold chain-free vaccine would relieve the significant bottlenecks and cost ...
Lu, Zengsheng He, Beihui Chen, Zhiyun Yan, Maoxiang Wu, Liyan
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BMC Immunology
BackgroundNonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in the progression of nonalcoholic fatty liver disease. Our study investigated the possible molecular mechanisms of berberine (BBR) i...
Gerstner, Christina Turcinov, Sara Hensvold, Aase H. Chemin, Karine Uchtenhagen, Hannes Ramwadhdoebe, Tamara H. Dubnovitsky, Anatoly Kozhukh, Genadiy Rönnblom, Lars Kwok, William W.
...
Published in
BMC Immunology
BackgroundHLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune diseases. Rheumatoid arthritis (RA) is a chronic autoimmune disorder for which many autoantigens have been described.ResultsUsing mu...
Xu, Jinrui Zhou, Yanbing Yang, Yi Lv, Cuiping Liu, Xiaoming Wang, Yujiong
Published in
BMC Immunology
BackgroundUnderstanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent studies demonstrated that host cholesterol levels have implications in the establishment of Mycobacterium tuberculosis (M. tuberculosis, Mtb) infection in host cells, in which the intrac...
Peterson, Milene Murphy, Sierra Nicole Lainson, John Zhang, Jian Shen, Luhui Diehnelt, Chris W. Johnston, Stephen Albert
Published in
BMC Immunology
BackgroundIt is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It requires obtaining and sequencing tumor DNA/RNA, predicting potentially immunogenic neoepitopes and manufacturing a one-use vaccine. T...
Meckley, Lisa M. Wu, Yanyu Ito, Diane Berner, Todd McCoy, Barbara Yel, Leman
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BMC Immunology
BackgroundOften, patients with primary immunodeficiency diseases (PID), which are marked by the absence or loss of functional antibodies, require lifelong treatment with immunoglobulin (IG) replacement therapy administered either intravenously (intravenous immunoglobulin [IVIG]) or subcutaneously (subcutaneous immunoglobulin [SCIG]). In patients wi...
Liu, Guihuan Yu, Yuming Feng, Fu Zhu, Ping Zhang, Hua Zhang, Danni Feng, Xiaoqiang Zhang, Zedan Liu, Yanjun
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BMC Immunology
BackgroundCD8+CD28− T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro.ResultsCD8+CD28− Ts cells were expanded by stimulating human CD8+ T cells with allogeneic antigen presenting cells in the presence of the c...
McGoverne, Isabella Dunn, Jenny Batham, Jacob Tu, Wen Juan Chrisp, Jeremy Rao, Sudha
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BMC Immunology
BackgroundCancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell tolerance to cancers, thereby facilitating tumor progression. The recent clinical success of immunotherapy, particularly checkpoint...
Shen, Yuqi Ma, Yuhua Xie, Jingyuan Lin, Li Shi, Yifan Li, Xiao Shen, Pingyan Pan, Xiaoxia Ren, Hong
Published in
BMC Immunology
BackgroundCD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren’s syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to ...
Cho, Whajung Choe, Jongseon
Published in
BMC Immunology
BackgroundProstaglandin E2 (PGE2) is an endogenous lipid mediator of inflammation. Its production is regulated by the rate-limiting upstream enzyme cyclooxygenase-2 (COX-2). We have recently demonstrated that the major cell type expressing COX-2 in the germinal center is follicular dendritic cell (FDC). In this study, to elucidate the molecular mec...
