Desalegn, Girmay Tsegaye, Aster Gebreegziabiher, Dawit Aseffa, Abraham Howe, Rawleigh
Published in
BMC Immunology
BackgroundHIV-infected individuals with latent TB infection are at increased risk of developing active TB. HAART greatly reduces the incidence rate of TB in HIV-infected patients and reconstitutes Mycobacterium tuberculosis (M. tuberculosis)-specific immune response in the first 12 months of therapy. The durability of the anti-mycobacterial immune ...
Ogawa, Kazushige Tsurutani, Mayu Hashimoto, Aya Soeda, Miharu
Published in
BMC Immunology
BackgroundResident macrophages (Mø) originating from yolk sac Mø and/or foetal monocytes colonise tissues/organs during embryonic development. They persist into adulthood by self-renewal at a steady state, independent of adult monocyte inputs, except for those in the intestines and dermis. Thus, many resident Mø can be propagated in vitro under opt...
Aziz, Najib Detels, Roger Quint, Joshua J. Gjertson, David Ryner, Timothy Butch, Anthony W.
Published in
BMC Immunology
BackgroundCytokines, chemokines, adipocytokines, soluble cell receptors, and immune activation markers play an important role in immune responsiveness and can provide prognostic value since they reflect underlying conditions and disease states. This study was undertaken to investigate the components of biological variation for various laboratory te...
Zhao, Chunmiao Chu, Yanfang Liang, Zhaoyun Zhang, Bingying Wang, Xuxia Jing, Xiaona Hao, Meihua Wang, Yiqi An, Jia Zhang, Xingzhe
...
Published in
BMC Immunology
BackgroundThe development of Systemic lupus erythematosus (SLE) has been associated with the balance of Th17 and Treg cells. IL-2 and rapamycin can influence the populations of both Th17 and Treg cells. However, it is unclear whether low dose of IL-2 and rapamycin can relieve the symptoms of SLE patients and what is the mechanisms. In this study, w...
Li, Chong-Xi Li, Yu-Ye He, Li-Ping Kou, Jing Bai, Jin-Song Liu, Jun Tian, Bo Cao, Li-Juan Wang, Kun-Hua Kuang, Yi-Qun
...
Published in
BMC Immunology
BackgroundThe immune reconstitution after initiation of highly active antiretroviral therapy (HAART) among HIV-infected individuals substantially affects patients’ prognosis. However, the dynamic characteristics and predictors of reconstitution outcome remain unclear.MethodsIn this study, the HIV/AIDS patients with sustained virological suppression...
Rahban, Dariush Mohammadi, Forogh Alidadi, Mehdi Ghantabpour, Taha Kheyli, Pedram Abbasi Ghasem Ahmadi, Majid
Published in
BMC Immunology
BackgroundThe persistent the inflammatory condition in multiple sclerosis (MS) may due to the aberrant regulation of the elimination of the pathogenic autoreactive lymphocytes through apoptosis. Survivin, encoded by the BIRC5 gene, has been indicated to be involved in the regulation of apoptosis. This survey intended to investigate the genetic and ...
Parker, Antony R. Skold, Markus Harding, Stephen Barton, J. Clayborn Bertoli, Luigi F. Barton, James C.
Published in
BMC Immunology
BackgroundWe sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL and aggregate response as IgG > 1...
Yue, Tao Ji, Mei Qu, Huanru Guo, Mengru Bai, Fengmin Zhang, Zhanming Wang, Weifeng Gong, Xuming Zhang, Zhenghua
Published in
BMC Immunology
BackgroundThe aim of the current study was to investigate the long non-coding RNA (lncRNA) expression profiles in psoriatic arthritis (PSA) patients by RNA sequencing, and to further explore potential biomarkers that were able to predict PSA risk and activity.MethodsLncRNA and mRNA expression profiles in peripheral blood mononuclear cells (PBMC) of...
Dong, Yuejiao Li, Xuefen Zhang, Lu Zhu, Qiaoyun Chen, Chunlei Bao, Jiaqi Chen, Yu
Published in
BMC Immunology
BackgroundImmune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection. Here, we analyzed the relationship between programmed death-1 (PD-1) and lymphocyte activation gene-3 (LAG-3) expression on CD4+ T cells and HBV disease progression.ResultsPD-1 and LAG-3...
Yan, Lin Li, Yamei Li, Yi Wu, Xiaojuan Wang, Xianding Wang, Lanlan Shi, Yunying Tang, Jiangtao
Published in
BMC Immunology
BackgroundT follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit Tfh-B cell interaction.MethodsTo identify whether circulating Tfh (cTfh) and Tfr (cTfr) cells contribute to chronic renal allograft dysfunction (CAD), 67 kidney transplant recip...
