Xu, Ling Liu, Yubin Song, Xiaojing Li, Yanling Han, Yang Zhu, Ting Cao, Wei Li, Taisheng
Published in
BMC Immunology
BackgroundSome long-term non-progressors (LTNPs) have decreasing CD4+ T cell counts and progress to AIDS. Exploring which subsets of CD4+ T cell decreasing and the determinants associated with the decay in these patients will improve disease progression surveillance and provide further understanding of HIV pathogenesis.MethodsTwenty-five LTNPs infe...
Ramu, Sangeetha Akbarshahi, Hamid Mogren, Sofia Berlin, Frida Cerps, Samuel Menzel, Mandy Hvidtfeldt, Morten Porsbjerg, Celeste Uller, Lena Andersson, Cecilia K.
...
Published in
BMC Immunology
BackgroundMast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the pathogenesis of asthma exacerbations. However, effects of MC mediators on bronchial epithelial immune respo...
Qiong, Huang Han, Ling Zhang, Nanxue Chen, Huyan Yan, Kexiang Zhang, Zhenghua Ma, Ying Xu, Jinhua
Published in
BMC Immunology
BackgroundThe anti-inflammatory effect of glycyrrhizin has been widely recognized, while the specific mechanism of glycyrrhizin in psoriasis remains poorly understood.ResultsIn the imiquimod-induced mouse model of psoriasis (IMD), we found that glycyrrhizin can substantially improve the adverse symptoms in mice. The hematoxylin-eosin staining resul...
Liu, Jiajia Tian, Xiaoyi Wang, Yan Kang, Xixiong Song, Wenqi
Published in
BMC Immunology
BackgroundThe cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is widely considered as a pivotal immune checkpoint molecule to suppress antitumor immunity. However, the significance of soluble CTLA-4 (sCTLA-4) remains unclear in the patients with brain glioma. Here we aimed to investigate the significance of serum sCTLA-4 levels as a noninvasiv...
Benjamin, Sarah J. Hawley, Kelly L. Vera-Licona, Paola La Vake, Carson J. Cervantes, Jorge L. Ruan, Yijun Radolf, Justin D. Salazar, Juan C.
Published in
BMC Immunology
BackgroundMacrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88−/−Bb-stimulated bone marrow-derived macrophages (BMDMs).ResultsMyD88−/− B...
Andrade, Itana Gomes Alves de Souza, Fabíola Isabel Suano Fonseca, Fernando Luiz Affonso Aranda, Carolina Sanchez Sarni, Roseli Oselka Saccardo
Published in
BMC Immunology
BackgroundCommon variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this immune-inflammatory stimulation and increased oxidative stress. A positive impact on the survival of pa...
Lee, Hwa-Youn Lee, Eun-Hee Yi, Jawoon Ji, Kon-Young Kim, Su-Man Choi, Ha-Rim Yee, Su-Min Kang, Hyung-Sik Kim, Eun-Mi
Published in
BMC Immunology
BackgroundTriggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity, and Alzheimer’s disease pathogenesis. However, little is known regarding the effect of TREM2 on natural killer (NK) cells.ResultsH...
Hong, Xiaoyang Li, Shuanglei Wang, Jie Zhao, Zhe Feng, Zhichun
Published in
BMC Immunology
BackgroundCircular RNA circFADS2 plays protective roles in LPS-induced inflammation, which promotes sepsis, suggesting its involvement in sepsis.MethodsExpression of circFADS2, mature miR-15a-5p, and miR-15a-5p precursor in plasma samples from sepsis patients and healthy controls was determined by RT-qPCR. The circFADS2 expression vector was transf...
Mendes, João Rodrigues-Santos, Paulo Areia, Ana Luísa Almeida, Jani-Sofia Alves, Vera Santos-Rosa, Manuel Mota-Pinto, Anabela
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BMC Immunology
BackgroundPreterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, the inflammatory process plays a pivotal role during the...
Smits, Mark Meijerink, Marjolein Le, Thuy-My Knulst, André de Jong, Aard Caspers, Martinus Petrus Maria Lima, Everton Souto Babé, Lilia Ladics, Gregory McClain, Scott
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Published in
BMC Immunology
BackgroundFood proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigate the potential of a human peripheral blood mononuclear cell (PBMC) gene expression assay to identify biomarkers to predict the all...
