Fatemi, Alimohammad Alipour, Razieh Khanahmad, Hossein Alsahebfosul, Fereshteh Andalib, Alireza Pourazar, Abbasali
Published in
BMC Immunology
BackgroundNET (neutrophil extracellular trap) has been shown to directly influence inflammation; in SLE (systemic lupus erythematosus), it is reportedly a plausible cause for the broken self-tolerance that contributes to this pathology. Meanwhile, the role of NET is not easily explicable, and there is a serious discrepancy in the role of NET in SLE...
Li, Qingran Liu, Weiping Gao, Shidong Mao, Yao Xin, Yanfei
Published in
BMC Immunology
BackgroundInterleukin-17A (IL17A) is a proinflammatory cytokine critically involved in autoimmune diseases, and monoclonal antibodies of IL17A have been approved for clinical treatment of psoriasis. However, a usable psoriatic animal model has been always required for preclinical evaluation of IL17A antagonists. Imiquimod (IMQ)-induced psoriasis mo...
Alemnew, Birhan Hoff, Soren T. Abebe, Tamrat Abebe, Markos Aseffa, Abraham Howe, Rawleigh Wassie, Liya
Published in
BMC Immunology
BackgroundUnderstanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their roles as potential diagnostic ...
Liu, Yixuan Xie, Suhong Li, Lei Si, Yanhui Zhang, Weiwei Liu, Xin Guo, Lin Liu, Baochi Lu, Renquan
Published in
BMC Immunology
BackgroundThis study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL).MethodsA total of 32 patients with ARL participated in this study. Among them, 16 participants were treated with conventional surgery and chemotherapy (...
Zhu, Qingling Wang, Junli Ma, Jingqiu Sheng, Xiaoyang Li, Feng
Published in
BMC Immunology
BackgroundThe role of serum S100A8/A9 in intestinal inflammation has been confirmed, and its role in food allergy is currently being investigated.ObjectiveTo explore the levels of S100A8/A9 and inflammatory factors, including Toll-like receptors 4 (TLR4), Nuclear transcription factors (NF-κB) and Tumor necrosis factor α (TNF-α), in mild food allerg...
Tucker, Samantha L. Sarr, Demba Rada, Balázs
Published in
BMC Immunology
BackgroundNeutrophils are key components of the exacerbated inflammation and tissue damage in cystic fibrosis (CF) airways. Neutrophil extracellular traps (NETs) trap and kill extracellular pathogens. While NETs are abundant in the airways of CF patients and have been hypothesized to contribute to lung damage in CF, the in vivo role of NETs remains...
Wang, Qiu-bo Du, Yun-ting Liu, Fei Sun, Xiao-dan Sun, Xun Chen, Guang Pang, Wei Cao, Ya-Ming
Published in
BMC Immunology
BackgroudIt is important to expound the opposite clinical outcomes between children and adulthood for eradicate malaria. There remains unknown about the correlation between adaptive immune response and age-related in malaria.Methods4 and 8-week-old mice were used to mimic children and adulthood, respectively. Parasitemia and the survival rate were ...
Garg, Himanshu Yeh, Rose Watts, Douglas M. Mehmetoglu-Gurbuz, Tugba Resendes, Robert Parsons, Bruce Gonzales, Fernando Joshi, Anjali
Published in
BMC Immunology
BackgroundRecent outbreaks of Zika Virus (ZIKV) infection and associated microcephaly has raised multiple scientific questions. The close antigenic relatedness between flaviviruses makes diagnosis of specific infection difficult. This relatedness also raises the potential of Antibody Dependent Enhancement (ADE) via cross reactive antibodies to flav...
Xiu, Weigang Luo, Jingjing
Published in
BMC Immunology
BackgroundTumor-associated dendritic cells (TADCs) can interact with tumor cells to suppress anti-tumor T cell immunity. However, there is no information on whether and how TADCs can modulate programmed death-ligand 1 (PD-L1) expression by cancer cells.MethodsHuman peripheral blood monocytes were induced for DCs and immature DCs were cultured alone...
Li, Jingyang Wu, Jinhong Liu, Haipei Hua, Li Liu, Quanhua Fang, Dingzhu Chen, Yi Ji, Ruoxu Zhang, Jianhua Zhong, Wenwei
...
Published in
BMC Immunology
BackgroundNo reliable biological marker for the diagnosis of asthma in younger children is currently available. In this study, we analyzed the differences in basophil activation test (BAT) results among children with recurrent wheezing episodes who had different asthma outcomes.ResultsA prospective cohort study was conducted in children aged under ...
