Boilève, Alice Maillard, Aline Wagner, Mathilde Dromain, Clarisse Laurent, Christophe Bierre, Eric Dupont Le Sourd, Samuel Audemar, Franck Ulusakarya, Ayhan Guerin-Meyer, Veronique
...
Published in
BMC Cancer
BackgroundApproximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10–15% of CRLM are initially considered resectable. The objective response rates (ORR) after current first-line systemic chemotherapy (s...
Sun, Kai-Yu Hu, Hang-Tong Chen, Shu-Ling Ye, Jin-Ning Li, Guang-Hua Chen, Li-Da Peng, Jian-Jun Feng, Shi-Ting Yuan, Yu-Jie Hou, Xun
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Published in
BMC Cancer
BackgroundNeoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients’ responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatment response to neoadjuvant chemotherapy and to investigate its efficacy in survival stratification.MethodsA total of 106 patients w...
Singleton, Dean C. Dechaume, Anne-Lise Murray, Pamela M. Katt, William P. Baguley, Bruce C. Leung, Euphemia Y.
Published in
BMC Cancer
BackgroundGlutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate has many uses, including acting as an anaplerotic substrate (via alpha-ketoglutarate) to replenish TCA cycle in...
Tran, Maxine G. B. Bibby, Becky A. S. Yang, Lingjian Lo, Franklin Warren, Anne Y. Shukla, Deepa Osborne, Michelle Hadfield, James Carroll, Thomas Stark, Rory
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Published in
BMC Cancer
BackgroundTherapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to castrate-resistant prostate cancer (CRPC). Hypoxia and HIF1a have been implicated in the development of resistance to andro...
Berghen, Charlien Joniau, Steven Rans, Kato Devos, Gaëtan Poels, Kenneth Slabbaert, Koen Dumez, Herlinde Albersen, Maarten Goffin, Karolien Haustermans, Karin
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Published in
BMC Cancer
BackgroundPatients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2–3 years. A subgroup of those patients with mCRPC presents with oligoprogressive disease, with a limited number of progressive lesions while other metastases are still controlle...
Thiis-Evensen, Espen Poole, Amalie Christine Nguyen, Hong-Thien Thi Sponheim, Jon
Published in
BMC Cancer
BackgroundThere are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis has been put on inducing the tumors to stop growing without a reduction in total tumor load; termed as stable disease (SD). We wa...
Howlett, Jennifer Benzenine, Eric Cottenet, Jonathan Foucher, Pascal Fagnoni, Philippe Quantin, Catherine
Published in
BMC Cancer
BackgroundVenous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to evaluate the impact of VTE and major bleeding on survival and to identify significant risk factors for these events in lung cancer pati...
Lin, Hsuan-Jen Sheu, Phillip C.-Y. Tsai, Jeffrey J. P. Wang, Charles C. N. Chou, Che-Yi
Published in
BMC Cancer
BackgroundUrothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature can be challenging. In this study, we use text mining to explore UC publications to identify important information that may lead to...
Cong, Rong Kong, Fanfei Ma, Jian Li, Qing Wu, Qijun Ma, Xiaoxin
Published in
BMC Cancer
BackgroundThe preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancers but are always discussed separately. The aim of this study is to bring the combination of NLR, PLR and MLR into the prognostic as...
Kpoghomou, Marce-Amara Wang, Jinchen Wang, Tianpei Jin, Guanfu
Published in
BMC Cancer
BackgroundThe association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.MethodsCase-control studies involving the association between H. pylori babA2 gene ...
