Couderc, Anne-Laure Villani, Patrick Berbis, Julie Nouguerède, Emilie Rey, Dominique Rossi, Dominique Lechevallier, Éric Badinand, Delphine Bastide, Cyrille Karsenty, Gilles
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Published in
BMC Cancer
BackgroundSarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal muscle mass. Ageing greatly contributes to sarcopenia as may many other factors such as cancer or androgen deprivation therapies (ADT). This cohort study aims to evaluate (1) the prevalence of muscle disorders and sarcopenia in older patients before in...
Reis, Joana Boavida, Joao Tran, Hang T. Lyngra, Marianne Reitsma, Laurens Cornelus Schandiz, Hossein Melles, Woldegabriel A. Gjesdal, Kjell-Inge Geisler, Jürgen Geitung, Jonn Terje
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Published in
BMC Cancer
Background Axillary lymph node (LN) metastasis is one of the most important predictors of recurrence and survival in breast cancer, and accurate assessment of LN involvement is crucial. Determining extent of residual disease is key for surgical planning after neoadjuvant therapy. The aim of the study was to evaluate the diagnostic reliability of MR...
Ruan, Guo-Tian Xie, Hai-Lun Gong, Yi-Zhen Ge, Yi-Zhong Zhang, Qi Wang, Zi-Wen Zhang, Xi Zhang, He-Yang Tang, Meng Song, Meng-Meng
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Published in
BMC Cancer
Background Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in patients with cancer. Methods This multicenter prospective study included 5,221 patients with cancer, with a mean age of 59.41±11.1...
Wieczorek, Aleksandra Stefanowicz, Joanna Hennig, Marcin Adamkiewicz-Drozynska, Elzbieta Stypinska, Marzena Dembowska-Baginska, Bozenna Gamrot, Zuzanna Woszczyk, Mariola Geisler, Julia Szczepanski, Tomasz
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Published in
BMC Cancer
Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the presentation and assessment of the incidence and clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients trea...
Principe, Daniel R. Cataneo, Jose L. Timbers, Kaytlin E. Koch, Regina M. Valyi-Nagy, Klara Mellgren, Anders Rana, Ajay Gantt, Gerald
Published in
BMC Cancer
Background Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care chemoradiation. However, outcomes are poor for the 20–30% of patients who are refractory to this approach, and many will require additional invasive procedures with no guarantee of disease resolution. Method...
Luo, Qian-wen Gao, Shan Lv, Xiao Li, Si-jia Wang, Bo-fang Han, Qing-qing Wang, Yun-peng Guan, Quan-lin Gong, Tao
Published in
BMC Cancer
Nimptsch, Katharina Aleksandrova, Krasimira Fedirko, Veronika Jenab, Mazda Gunter, Marc J Siersema, Peter D Wu, Kana Katzke, Verena Kaaks, Rudolf Panico, Salvatore
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Published in
BMC cancer
The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on d...
Deguchi, Sota Tanaka, Hiroaki Suzuki, Shugo Natsuki, Seji Mori, Takuya Miki, Yuichiro Yoshii, Mami Tamura, Tatsuro Toyokawa, Takahiro Lee, Shigeru
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Published in
BMC Cancer
Background Tertiary lymphoid structures (TLSs) have been reported to be involved in immune responses in many carcinomas. This study investigated the significance of TLSs in esophageal squamous cell carcinoma, focusing on TLS maturation. Methods The relationships of TLSs with clinicopathological features of 236 patients who underwent curative surge...
Lin, Zheng Rao, Wenqing Xiang, Zhisheng Zeng, Qiaoyan Liu, Shuang Yu, Kaili Zhou, Jinsong Wang, Jianwen Chen, Weilin Chen, Yuanmei
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Published in
BMC cancer
Esophageal microbiota may influence esophageal squamous cell carcinoma (ESCC) pathobiology. Therefore, we investigated the characteristics and interplay of the esophageal microbiota in ESCC. We performed 16S ribosomal RNA sequencing on paired esophageal tumor and tumor-adjacent samples obtained from 120 primarily ESCC patients. Analyses were perfor...
Gou, Rui Zheng, Mingjun Hu, Yuexin Gao, Lingling Wang, Shuang Liu, Ouxuan Li, Xiao Zhu, Liancheng Liu, Juanjuan Lin, Bei
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Published in
BMC cancer
Nucleolar and spindle-associated protein 1 (NUSAP1) was shown to be involved in cell cycle regulation in cancer. However, its prognostic value and underlying mechanism in ovarian cancer remain unclear. Oncomine, TCGA, CCLE, and UALCAN databases were used to analyze the expression level of NUSAP1 in ovarian cancer. The Kaplan-Meier plotter database ...
