Chen, Mingqiu Liu, Xiaohong Han, Chun Wang, Xin Zhao, Yidian Pang, Qingsong Sun, Xinchen Li, Gaofeng Zhang, Kaixian Li, Ling
...
Published in
BMC Cancer
BackgroundThe aim of the present study was to assess the efficacy of concurrent chemoradiotherapy (CRT) or radiotherapy alone (RT-alone) in elderly patients with esophageal squamous cell carcinoma (ESCC).MethodsThe clinical data of patients with ESCC treated with RT-alone or CRT were collected and retrospectively reviewed. The 1-, 3- and 5-year ove...
Gu, Bingxin Zhang, Jianping Ma, Guang Song, Shaoli Shi, Liqun Zhang, Yingjian Yang, Zhongyi
Published in
BMC Cancer
BackgroundIntratumoral heterogeneity has an enormous effect on patient treatment and outcome. The purpose of the current study was to establish and validate a nomogram with intratumoral heterogeneity derived from 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prognosis of 5-Year progression-free survival ...
Liang, Jianfeng Lv, Xiaomin Lu, Changyu Ye, Xun Chen, Xiaolin Fu, Jia Luo, Chenghua Zhao, Yuanli
Published in
BMC Cancer
BackgroundThe prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide basis for treatment and management of patients.MethodA total of 335 patients with glioma were included in this study. These patien...
Connell, Claire M. Brais, Rebecca Whitaker, Hayley Upponi, Sara Beh, Ian Risdall, Jane Corrie, Pippa Janowitz, Tobias Jodrell, Duncan I.
Published in
BMC Cancer
BackgroundPancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is largely unknown.Case presentationWe describe the case of a 51 year old woman with pancreatic adeno...
Yuan, Shuo Lin, Li-song Gan, Rui-Huan Huang, Li Wu, Xiao-ting Zhao, Yong Su, Bo-hua Zheng, Dali Lu, You-Guang
Published in
BMC Cancer
BackgroundMatrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression pattern and function in tongue cancer is not clear.MethodsThe expression of MMP7 in human tongue squamous cell carcinoma (TSCC) specimens...
Moore, Assaf Hikri, Elad Goshen-Lago, Tal Barkan, Tamar Morgenstern, Sara Brook, Elena Maderer, Annett Roth, Wilfried Gordon, Noa Kashtan, Hanoch
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Published in
BMC Cancer
ObjectiveGastric cancer (GC) is a leading cause of cancer death, occurs predominantly in older age, with increasing incidence in young patients. The Cancer Genome Atlas indicates four subtypes for GC among which Epstein-Barr virus (EBV) subtype is estimated at 8.7%. We aim to determine the prevalence of EBV subtype in young GC patients (≤45 years) ...
Zhang, Ji-Gang Zhou, He-Ming Zhang, Xue Mu, Wan Hu, Juan-Ni Liu, Gao-Lin Li, Qin
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BMC Cancer
BackgroundVasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated kinase (PAK), hypoxia or epithelial-mesenchymal transition (EMT) contributed to the VM potential. However, the details underlying ...
Liao, Xia Song, Ge Xu, Zihan Bu, Yang Chang, Fan Jia, Fengan Xiao, Xuelian Ren, Xuejiao Zhang, Mei Jia, Qingan
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Published in
BMC Cancer
BackgroundChemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportunity to impede tumor through combination or sequential therapy, while the accurate effect is vague.MethodsThe efficacy of combinatio...
Nielsen, Kirstine Binderup, Tina Langer, Seppo W. Kjaer, Andreas Knigge, Pauline Grøndahl, Veronica Melchior, Linea Federspiel, Birgitte Knigge, Ulrich
Published in
BMC Cancer
BackgroundHigh grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogranin A (CgA) and somatostatin-rec...
Yang, Ye Liu, Ping Yin Bao, Wei Chen, Song Jun Wu, Fang Su Zhu, Ping Ya
Published in
BMC Cancer
BackgroundPyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis.MethodsWe performed...
