Ramon-Mateu, Julia Ellison, S. Tori Angelini, Thomas E. Martindale, Mark Q.
Published in
BMC Biology
BackgroundThe ability to regenerate is a widely distributed but highly variable trait among metazoans. A variety of modes of regeneration has been described for different organisms; however, many questions regarding the origin and evolution of these strategies remain unanswered. Most species of ctenophore (or “comb jellies”), a clade of marine anim...
Kirst, Henning Kerfeld, Cheryl A.
Published in
BMC Biology
Bacterial cells have long been thought to be simple cells with little spatial organization, but recent research has shown that they exhibit a remarkable degree of subcellular differentiation. Indeed, bacteria even have organelles such as magnetosomes for sensing magnetic fields or gas vesicles controlling cell buoyancy. A functionally diverse group...
Quan, Honghu Arsala, Deanna Lynch, Jeremy A.
Published in
BMC Biology
BackgroundThe oosome is the germline determinant in the wasp Nasonia vitripennis and is homologous to the polar granules of Drosophila. Despite a common evolutionary origin and developmental role, the oosome is morphologically quite distinct from polar granules. It is a solid sphere that migrates within the cytoplasm before budding out and forming ...
Xu, Tong Yuchi, Zhiguang
Published in
BMC Biology
BackgroundRyanodine receptor (RyR), a calcium-release channel located in the sarcoplasmic reticulum membrane of muscles, is the target of insecticides used against a wide range of agricultural pests. Mammalian RyRs have been shown to be under the regulatory control of several kinases and phosphatases, but little is known about the regulation of ins...
Willmann, Matthias Vehreschild, Maria J. G. T. Biehl, Lena M. Vogel, Wichard Dörfel, Daniela Hamprecht, Axel Seifert, Harald Autenrieth, Ingo B. Peter, Silke
Published in
BMC Biology
BackgroundThe selection pressure exercised by antibiotic drugs is an important consideration for the wise stewardship of antimicrobial treatment programs. Treatment decisions are currently based on crude assumptions, and there is an urgent need to develop a more quantitative knowledge base that can enable predictions of the impact of individual ant...
Kuon, Joel-E. Qi, Weihong Schläpfer, Pascal Hirsch-Hoffmann, Matthias von Bieberstein, Philipp Rogalla Patrignani, Andrea Poveda, Lucy Grob, Stefan Keller, Miyako Shimizu-Inatsugi, Rie
...
Published in
BMC Biology
BackgroundCassava is an important food crop in tropical and sub-tropical regions worldwide. In Africa, cassava production is widely affected by cassava mosaic disease (CMD), which is caused by the African cassava mosaic geminivirus that is transmitted by whiteflies. Cassava breeders often use a single locus, CMD2, for introducing CMD resistance int...
Xu, Ziye You, Wenjing Zhou, Yanbing Chen, Wentao Wang, Yizhen Shan, Tizhong
Published in
BMC Biology
BackgroundIn mammals, cold exposure induces browning of white adipose tissue (WAT) and alters WAT gene expression and lipid metabolism to boost adaptive thermogenesis and maintain body temperature. Understanding the lipidomic and transcriptomic profiles of WAT upon cold exposure provides insights into the adaptive changes associated with this proce...
Zhou, Haining Zheng, Tao Wang, Tianning Li, Qi Wang, Fulin Liang, Xin Chen, Jianguo Teng, Junlin
Published in
BMC Biology
BackgroundSpindle microtubule organization, regulated by microtubule-associated proteins, is critical for cell division. Proper organization of kinetochore fiber (K-fiber), connecting spindle poles and kinetochores, is a prerequisite for precise chromosomal alignment and faithful genetic material transmission. However, the mechanisms of K-fiber org...
Park, Sung-Joon Onizuka, Satoru Seki, Masahide Suzuki, Yutaka Iwata, Takanori Nakai, Kenta
Published in
BMC Biology
BackgroundMicrobial contamination poses a major difficulty for successful data analysis in biological and biomedical research. Computational approaches utilizing next-generation sequencing (NGS) data offer promising diagnostics to assess the presence of contaminants. However, as host cells are often contaminated by multiple microorganisms, these ap...
Bando, Yuki Grimm, Christiane Cornejo, Victor H Yuste, Rafael
Published in
BMC Biology
As a “holy grail” of neuroscience, optical imaging of membrane potential could enable high resolution measurements of spiking and synaptic activity in neuronal populations. This has been partly achieved using organic voltage-sensitive dyes in vitro, or in invertebrate preparations yet unspecific staining has prevented single-cell resolution measure...
