Horemans, Steff Pitoulias, Matthaios Holland, Alexandria Pateau, Emilie Lechaplais, Christophe Ekaterina, Dariy Perret, Alain Soultanas, Panos Janniere, Laurent
Published in
BMC Biology
Background In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences for cell viability and human health, including cancer. To cope with these th...
Martinez, P. Ballarin, L. Ereskovsky, A. V. Gazave, E. Hobmayer, B. Manni, L. Rottinger, E. Sprecher, S. G. Tiozzo, S. Varela-Coelho, A.
...
Published in
BMC Biology
Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have ...
Bon, Cécile Cabantous, Stéphanie Julien, Sylviane Guillet, Valérie Chalut, Christian Rima, Julie Brison, Yoann Malaga, Wladimir Sanchez-Dafun, Angelique Gavalda, Sabine
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Published in
BMC Biology
Background Type I polyketide synthases (PKSs) are multifunctional enzymes responsible for the biosynthesis of a group of diverse natural compounds with biotechnological and pharmaceutical interest called polyketides. The diversity of polyketides is impressive despite the limited set of catalytic domains used by PKSs for biosynthesis, leading to con...
Tantoso, Erwin Eisenhaber, Birgit Kirsch, Miles Shitov, Vladimir Zhao, Zhiya Eisenhaber, Frank
Published in
BMC biology
Escherichia coli (E. coli) has been one of the most studied model organisms in the history of life sciences. Initially thought just to be commensal bacteria, E. coli has shown wide phenotypic diversity including pathogenic isolates with great relevance to public health. Though pangenome analysis has been attempted several times, there is no systema...
Mahly, Adnan Padmanabhan, Krishnanand Soffer, Arad Cohen, Jonathan Omar, Jana Sagi-Eisenberg, Ronit Luxenburg, Chen
Published in
BMC biology
The establishment of tissue architecture requires coordination between distinct processes including basement membrane assembly, cell adhesion, and polarity; however, the underlying mechanisms remain poorly understood. The actin cytoskeleton is ideally situated to orchestrate tissue morphogenesis due to its roles in mechanical, structural, and regul...
Sun, Xiyang Liu, Yingtao Liu, Chang Mayumi, Koichi Ito, Kohzo Nose, Akinao Kohsaka, Hiroshi
Published in
BMC Biology
Background Animal locomotion requires dynamic interactions between neural circuits, the body (typically muscles), and surrounding environments. While the neural circuitry of movement has been intensively studied, how these outputs are integrated with body mechanics (neuromechanics) is less clear, in part due to the lack of understanding of the biom...
Gao, Yaning Tai, Wanbo Wang, Xinyi Jiang, Shibo Debnath, Asim K Du, Lanying Chen, Shizhong
Published in
BMC biology
Zika virus (ZIKV) and dengue virus (DENV) cause microcephaly and dengue hemorrhagic fever, respectively, leading to severe problems. No effective antiviral agents are approved against infections of these flaviviruses, calling for the need to develop potent therapeutics. We previously identified gossypol as an effective inhibitor against ZIKV and DE...
Nelson, Randy J Bumgarner, Jacob R Liu, Jennifer A Love, Jharnae A Meléndez-Fernández, O Hecmarie Becker-Krail, Darius D Walker, William H 2nd Walton, James C DeVries, A Courtney Prendergast, Brian J
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Published in
BMC biology
Circadian rhythms are important for all aspects of biology; virtually every aspect of biological function varies according to time of day. Although this is well known, variation across the day is also often ignored in the design and reporting of research. For this review, we analyzed the top 50 cited papers across 10 major domains of the biological...
Cypris, Olivia Franzen, Julia Frobel, Joana Glück, Philipp Kuo, Chao-Chung Schmitz, Stephani Nüchtern, Selina Zenke, Martin Wagner, Wolfgang
Published in
BMC biology
DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B). DNMT3A is one of the most frequently mutated genes in clonal hematopoiesis and leukemia, indicating that it plays a crucial role for hematopoietic different...
Wu, Baojun Hao, Weilong Cox, Murray P
Published in
BMC biology
Fungi exhibit astonishing diversity with multiple major phenotypic transitions over the kingdom's evolutionary history. As part of this process, fungi developed hyphae, adapted to land environments (terrestrialization), and innovated their sexual structures. These changes also helped fungi establish ecological relationships with other organisms (an...
