Martinez, P. Ballarin, L. Ereskovsky, A. V. Gazave, E. Hobmayer, B. Manni, L. Rottinger, E. Sprecher, S. G. Tiozzo, S. Varela-Coelho, A.
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Published in
BMC Biology
Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have ...
Meshnik, Lana Bar-Yaacov, Dan Kasztan, Dana Neiger, Tali Cohen, Tal Kishner, Mor Valenci, Itay Dadon, Sara Klein, Christopher J. Vance, Jeffery M.
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Published in
BMC Biology
BackgroundMitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules frequently co-exist (heteroplasmy). A number of factors, such as replicative segregation, mitochondrial bottlene...
Chen, Wei Chen, Yushi Wu, Ruifan Guo, Guanqun Liu, Youhua Zeng, Botao Liao, Xing Wang, Yizhen Wang, Xinxia
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BMC Biology
BackgroundObesity leads to a decline in the exercise capacity of skeletal muscle, thereby reducing mobility and promoting obesity-associated health risks. Dietary intervention has been shown to be an important measure to regulate skeletal muscle function, and previous studies have demonstrated the beneficial effects of docosahexaenoic acid (DHA; 22...
Hakeemi, Muhammad Salim Ansari, Salim Teuscher, Matthias Weißkopf, Matthias Großmann, Daniela Kessel, Tobias Dönitz, Jürgen Siemanowski, Janna Wan, Xuebin Schultheis, Dorothea
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Published in
BMC Biology
BackgroundMost of the known genes required for developmental processes have been identified by genetic screens in a few well-studied model organisms, which have been considered representative of related species, and informative—to some degree—for human biology. The fruit fly Drosophila melanogaster is a prime model for insect genetics, and while co...
Morozova, Daria S. Martyanov, Alexey A. Obydennyi, Sergei I. Korobkin, Julia-Jessica D. Sokolov, Alexey V. Shamova, Ekaterina V. Gorudko, Irina V. Khoreva, Anna L. Shcherbina, Anna Panteleev, Mikhail A.
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Published in
BMC Biology
BackgroundThe process of thrombus formation is thought to involve interactions between platelets and leukocytes. Leukocyte incorporation into growing thrombi has been well established in vivo, and a number of properties of platelet-leukocyte interactions critical for thrombus formation have been characterized in vitro in thromboinflammatory setting...
Camacho, Juan Pedro M. Cabrero, Josefa López-León, María Dolores Martín-Peciña, María Perfectti, Francisco Garrido-Ramos, Manuel A. Ruiz-Ruano, Francisco J.
Published in
BMC Biology
BackgroundThe full catalog of satellite DNA (satDNA) within a same genome constitutes the satellitome. The Library Hypothesis predicts that satDNA in relative species reflects that in their common ancestor, but the evolutionary mechanisms and pathways of satDNA evolution have never been analyzed for full satellitomes. We compare here the satellitom...
Hou, Xiao-Qing Zhang, Dan-Dan Powell, Daniel Wang, Hong-Lei Andersson, Martin N. Löfstedt, Christer
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BMC Biology
BackgroundIn insects, airborne chemical signals are mainly detected by two receptor families, odorant receptors (ORs) and ionotropic receptors (IRs). Functions of ORs have been intensively investigated in Diptera and Lepidoptera, while the functions and evolution of the more ancient IR family remain largely unexplored beyond Diptera.ResultsHere, we...
Brand, Jeremias N. Harmon, Luke J. Schärer, Lukas
Published in
BMC Biology
BackgroundSex allocation is the distribution of resources to male or female reproduction. In hermaphrodites, this concerns an individual’s resource allocation to, for example, the production of male or female gametes. Macroevolutionary studies across hermaphroditic plants have revealed that the self-pollination rate and the pollination mode are str...
Engelman, Russell K.
Published in
BMC Biology
BackgroundBody mass estimation is of paramount importance for paleobiological studies, as body size influences numerous other biological parameters. In mammals, body mass has been traditionally estimated using regression equations based on measurements of the dentition or limb bones, but for many species teeth are unreliable estimators of body mass...
Sentmanat, Monica F. White, J. Michael Kouranova, Evguenia Cui, Xiaoxia
Published in
BMC Biology
BackgroundFloxed (flanked by loxP) alleles are a crucial portion of conditional knockout mouse models. However, an efficient and reliable strategy to flox genomic regions of any desired size is still lacking.ResultsHere, we demonstrate that the method combining electroporation of fertilized eggs with gRNA/Cas9 complexes and single-stranded oligodeo...
