Park, Kyerl Lee, Jaedong Jang, Hyun Jae Richards, Blake A. Kohl, Michael M. Kwag, Jeehyun
Published in
BMC Biology
BackgroundAbnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positive (SST) interneurons are critically involved in theta-neste...
Segal, Inbar Nachmias, Dikla Konig, Andres Alon, Ariel Arbely, Eyal Elia, Natalie
Published in
BMC Biology
BackgroundIn the high-resolution microscopy era, genetic code expansion (GCE)-based bioorthogonal labeling offers an elegant way for direct labeling of proteins in live cells with fluorescent dyes. This labeling approach is currently not broadly used in live-cell applications, partly because it needs to be adjusted to the specific protein under stu...
Lundin, Elin Wu, Chenglin Widmark, Albin Behm, Mikaela Hjerling-Leffler, Jens Daniel, Chammiran Öhman, Marie Nilsson, Mats
Published in
BMC Biology
BackgroundAdenosine-to-inosine (A-to-I) RNA editing is a process that contributes to the diversification of proteins that has been shown to be essential for neurotransmission and other neuronal functions. However, the spatiotemporal and diversification properties of RNA editing in the brain are largely unknown. Here, we applied in situ sequencing t...
Joo, Sunjoo Wang, Ming Hsiu Lui, Gary Lee, Jenny Barnas, Andrew Kim, Eunsoo Sudek, Sebastian Worden, Alexandra Z. Lee, Jae-Hyeok
Published in
BMC Biology
Upon publication of the original article [1], it was noticed that Alexandra Z. Worden’s affiliation is not complete. The full affiliation information for Alexandra Z. Worden is can be found below and in the complete affiliation list of this Correction article.
Armstrong, Ellie E. Taylor, Ryan W. Miller, Danny E. Kaelin, Christopher B. Barsh, Gregory S. Hadly, Elizabeth A. Petrov, Dmitri
Published in
BMC Biology
BackgroundThe lion (Panthera leo) is one of the most popular and iconic feline species on the planet, yet in spite of its popularity, the last century has seen massive declines for lion populations worldwide. Genomic resources for endangered species represent an important way forward for the field of conservation, enabling high-resolution studies o...
Rampelt, Heike Sucec, Iva Bersch, Beate Horten, Patrick Perschil, Inge Martinou, Jean-Claude van der Laan, Martin Wiedemann, Nils Schanda, Paul Pfanner, Nikolaus
...
Published in
BMC Biology
BackgroundThe mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane. Its heterodimeric composition and homology to SWEET and semiSWEET transporters set the MPC apart from the canonical mitochondrial carrier family (named MCF or SLC25). The import of the canoni...
Waterhouse, Robert M. Aganezov, Sergey Anselmetti, Yoann Lee, Jiyoung Ruzzante, Livio Reijnders, Maarten J. M. F. Feron, Romain Bérard, Sèverine George, Phillip Hahn, Matthew W.
...
Published in
BMC Biology
BackgroundNew sequencing technologies have lowered financial barriers to whole genome sequencing, but resulting assemblies are often fragmented and far from ‘finished’. Updating multi-scaffold drafts to chromosome-level status can be achieved through experimental mapping or re-sequencing efforts. Avoiding the costs associated with such approaches, ...
Foissac, Sylvain Djebali, Sarah Munyard, Kylie Vialaneix, Nathalie Rau, Andrea Muret, Kevin Esquerré, Diane Zytnicki, Matthias Derrien, Thomas Bardou, Philippe
...
Published in
BMC Biology
BackgroundComparative genomics studies are central in identifying the coding and non-coding elements associated with complex traits, and the functional annotation of genomes is a critical step to decipher the genotype-to-phenotype relationships in livestock animals. As part of the Functional Annotation of Animal Genomes (FAANG) action, the FR-AgENC...
Coutinho, F. H. Edwards, R. A. Rodríguez-Valera, F.
Published in
BMC Biology
BackgroundViruses of Archaea and Bacteria are among the most abundant and diverse biological entities on Earth. Unraveling their biodiversity has been challenging due to methodological limitations. Recent advances in culture-independent techniques, such as metagenomics, shed light on the unknown viral diversity, revealing thousands of new viral nuc...
Brysch, Christian Leyden, Claire Arrenberg, Aristides B.
Published in
BMC Biology
BackgroundThe oculomotor integrator (OI) in the vertebrate hindbrain transforms eye velocity input into persistent position coding output, which plays a crucial role in retinal image stability. For a mechanistic understanding of the integrator function and eye position control, knowledge about the tuning of the OI and other oculomotor nuclei is nee...
