Published in Nucleic Acids Research
The mission of UniProt is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces. UniProt is comprised of four major components, each optimized for different uses: the UniProt Arc...
Published in BMC bioinformatics
This theoretical study describes a model in which the inference of genome rearrangements and phylogeny can be unified under parsimony.
Published in BMC bioinformatics
The described filtering methods are advantageous for large population-based WES studies designed to identify common and rare variation associated with complex diseases. Compared to data processed through standard practices, these strategies result in substantially higher quality data for common and rare association analyses.
Published in BMC bioinformatics
The algorithms implemented in PIPA provide automated genome-wide protein function annotation based on reconciled predictions from multiple resources.
Published in BMC bioinformatics
The Algal Functional Annotation Tool aims to provide an integrated data-mining environment for algal genomics by combining data from multiple annotation databases into a centralized tool. This site is designed to expedite the process of functional annotation and the interpretation of gene lists, such as those derived from high-throughput RNA-seq ex...
Published in Methods in molecular biology (Clifton, N.J.)
Surface plasmon resonance (SPR) biosensors belong to label-free optical biosensing technologies. The SPR method is based on optical measurement of refractive index changes associated with the binding of analyte molecules in a sample to biorecognize molecules immobilized on the SPR sensor. Since late 1990's, SPR biosensors have become the main tool ...
Published in BMC bioinformatics
Specific, efficiently computable characteristics of sentences about biomolecular interactions were analyzed to better understand how to use these characteristics to extract how biomolecules interact.The text empirics method that was investigated, though arising from a classical tradition, has yet to be fully explored for the task of extracting biom...
Published in BMC bioinformatics
In conclusion, we have demonstrated that the use of family information can improve the quality of CNV calling and hopefully give more powerful association test of CNVs.
Published in BMC bioinformatics
We have developed an SVM prediction model for wild-type BCRP substrates based on a relatively large number of known wild-type BCRP substrates and non-substrates. This model may prove valuable for screening substrates and non-substrates of BCRP, a clinically important ABC efflux drug transporter.
Published in BMC bioinformatics
We present a web based software application to aid the laboratory scientist to capture, describe and share details about their experiments.
