Vela-Navarrete, Remigio Alcaraz, Antonio Rodríguez-Antolín, Alfredo Miñana López, Bernardino Fernández-Gómez, Jesús M Angulo, Javier C Castro Díaz, David Romero-Otero, Javier Brenes, Francisco J Carballido, Joaquín
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Published in
BJU international
To comprehensively evaluate the efficacy and safety of the hexanic extract of Serenoa repens (HESr, Permixon® ; Pierre Fabre Médicament, Castres, France), at a dose of 320 mg daily, as monotherapy for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). We conducted a systematic review and meta-anal...
Campschroer, Thijs Zhu, Xiaoye Vernooij, Robin W M Lock, Tycho M T W
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BJU international
To assess the effects of α-blockers compared to standard therapy or placebo for ureteric stones of ≤10 mm confirmed by imaging in adult patients presenting with symptoms of ureteric stone disease. We performed a systematic search in multiple databases and grey literature with no restrictions on the language of publication or publication status, up ...
Tsimafeyeu, Ilya Tjulandin, Sergei
Published in
BJU international
More than 50% of all patients with advanced urothelial carcinoma cannot receive highly toxic cisplatin-based chemotherapy as the first-line treatment because of their unsatisfactory performance status and co-morbidities. Replacement of cisplatin with carboplatin does not produce a desired improvement with regard to efficacy. In addition, 20% of pat...
Gandhi, Niket Krishna, Satheesh Booth, Christopher M Breau, Rodney H Flood, Trevor A Morgan, Scott C Schieda, Nicola Salameh, Jean-Paul McGrath, Trevor A McInnes, Matthew D F
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Published in
BJU international
The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of patients with bladder cancer underg...
Na, Rong Wu, Yishuo Jiang, Guangliang Yu, Hongjie Lin, Xiaoling Wang, Meilin Conran, Carly A Fantus, Richard J Zhang, Ning Liu, Shenghua
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BJU international
To perform a systematic evaluation of whether germline DNA repair gene mutations in bladder cancer (BCa) are associated with increased risk of BCa and aggressive disease. Germline DNA from 98 patients with BCa was analysed for 54 DNA repair genes using a customized targeted sequencing panel. Population control data were obtained from the public dat...
Mason, Samantha J Catto, James W F Downing, Amy Bottomley, Sarah E Glaser, Adam W Wright, Penny
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BJU international
Patient-reported outcome measures (PROMs) are important tools used to understand patient-focused outcomes from care. Various PROMs have been developed for patients with bladder cancer (BC), although the disease's heterogeneity makes selection difficult. Accurate measurement of health-related quality of life (HRQL) can only be achieved if the PROM c...
Cash, Hannes Steiner, Ursula Heidenreich, Axel Klotz, Theodor Albers, Peter Melchior, Sebastian Martus, Peter Fuller, Florian Magheli, Ahmed Hinz, Stefan
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Published in
BJU international
To investigate non-inferiority of intermittent docetaxel compared to continuous docetaxel in patients with metastatic castration-resistant prostate cancer (mCRPC). The investigator initiated randomised phase III study included 187 chemotherapy-naïve patients with mCRPC who were allocated to two treatment arms: intermittent docetaxel and continuous ...
Gielchinsky, Ilan Chang, John Cusick, Thomas Delprado, Warick Nguyen, Quoc Yuen, Carlo Savdie, Richard Böhm, Maret Haynes, Anne-Maree Scheltema, Matthijs J
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BJU international
To evaluate the clinical presentation and treatment outcomes of prostate cancer (PCa) in 432 consecutive patients aged
Kosarek, Christopher D Mahmoud, Ali M Eyzaguirre, Eduardo J Shan, Yong Walser, Eric M Horn, Gary L Williams, Stephen B
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BJU international
To describe a step-by-step guide for using the first transperineal targeted prostate biopsy platform available in the USA. A total of 32 men with elevated prostate-specific antigen (PSA) levels were diagnosed with a region of interest on multiparametric magnetic resonance imaging (mpMRI) between February 2017 and January 2018. The transperineal tar...
Loeb, Stacy Taneja, Sorab Walter, Dawn Zweifach, Sarah Byrne, Nataliya
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BJU international
