Singh, Sonia R Meyer-Jens, Moritz Alizoti, Erda Bacon, W Clark Davis, Gregory Osinska, Hanna Gulick, James Reischmann-Düsener, Silke Orthey, Ellen McLendon, Patrick M
...
Published in
Autophagy
The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway (ALP) are two major protein degradation pathways in eukaryotic cells. Initially considered as two independent pathways, there is emerging evidence that they can work in concert. As alterations of UPS and ALP function can contribute to neurodegenerative disorders, cancer and cardi...
Tang, Ying Liu, Jinchang Wang, Yu Yang, Li Han, Bing Zhang, Yuan Bai, Ying Shen, Ling Li, Mingyue Jiang, Teng
...
Published in
Autophagy
Stroke is a major public health problem leading to high rates of death and disability worldwide, but no effective pharmacological therapy is currently available except for the use of PLAT (plasminogen activator, tissue). Here we show that PARP14 (poly (ADP-ribose) polymerase family, member 14) level was significantly increased in the peri-infarct z...
Pant, Devesh C Nazarko, Taras Y
Published in
Autophagy
Selective autophagy is a specific elimination of certain intracellular substrates by autophagic pathways. The most studied macroautophagy pathway involves tagging and recognition of a specific cargo by the autophagic membrane (phagophore) followed by the complete sequestration of targeted cargo from the cytosol by the double-membrane vesicle, autop...
Yao, Weijing Li, Yixing Wu, Liming Wu, Choufei Zhang, Yi Liu, Jing He, Zhiyong Wu, Xiaoyong Lu, Chenjun Wang, Liefeng
...
Published in
Autophagy
How energy deprivation induces macroautophagy/autophagy is not fully understood. Here, we show that Atg11, a receptor protein for cargo recognition in selective autophagy, is required for the initiation of glucose starvation-induced autophagy. Upon glucose starvation, Atg11 facilitates the interaction between Snf1 and Atg1, thus is required for Snf...
Cheng, Jinbo Liao, Yajin Dong, Yuan Hu, Han Yang, Nannan Kong, Xiangxi Li, Shuoshuo Li, Xiaoheng Guo, Jifeng Qin, Lixia
...
Published in
Autophagy
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but the role of autophagy in microglial activation during PD development remains largely unclear. In this study, we showed that deletion of microglial Atg5 caused PD-like...
Delorme-Axford, Elizabeth Klionsky, Daniel J
Published in
Autophagy
In the preceding months, the novel SARS-CoV-2 pandemic has devastated global communities. The need for safe and effective prophylactic and therapeutic treatments to combat COVID-19 - the human disease resulting from SARS-CoV-2 infection - is clear. Here, we present recent developments in the effort to combat COVID-19 and consider whether SARS-CoV-2...
Miller, Katelyn McGrath, Marisa E Hu, Zhiqiang Ariannejad, Sohha Weston, Stuart Frieman, Matthew Jackson, William T
Published in
Autophagy
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is the most recent example of an emergent coronavirus that poses a significant threat to human health. Virus-host interactions play a major role in the viral life cycle and disease pathogenesis, and cellular pathways such as macroautophagy/autophagy prove to be either detrimental or beneficial ...
Marcelin, Genevieve Da Cunha, Carla Gamblin, Camille Suffee, Nadine Rouault, Christine Leclerc, Arnaud Lacombe, Amelie Sokolovska, Nataliya Gautier, Emmanuel L Clément, Karine
...
Published in
Autophagy
Adipose tissue (AT) fibrosis in obesity compromises adipocyte functions and responses to intervention-induced weight loss. It is driven by AT progenitors with dual fibro/adipogenic potential, but pro-fibrogenic pathways activated in obesity remain to be deciphered. To investigate the role of macroautophagy/autophagy in AT fibrogenesis, we used Pdgf...
Lloberas, Jorge Muñoz, Juan P Hernández-Álvarez, María Isabel Cardona, Pere-Joan Zorzano, Antonio Celada, Antonio
Published in
Autophagy
MFN2 (mitofusin 2) is required for mitochondrial fusion and for mitochondria-endoplasmic reticulum interaction. Using myeloid-conditional KO mice models, we found that MFN2 but not MFN1 is a prerequisite for the adaptation of mitochondrial respiration to stress conditions as well as for the production of reactive oxygen species (ROS). The deficient...
Ko, Su-Hyuk Apple, Ellen C Liu, Zhijie Chen, Lizhen
Published in
Autophagy
Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging. However, the role of autophagy in the neuronal response to axon injury and axon regeneration, particularly in the context of aging, remains largely unknown. Our candidate ge...
