Ogrič, Manca Poljšak, Katjuša Mrak Lakota, Katja Žigon, Polona Praprotnik, Sonja Semrl, Snezna Sodin Čučnik, Saša
Published in
Atherosclerosis
Patients with rheumatic diseases have an increased risk of atherosclerosis with up-regulated serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which were reported to activate human coronary artery endothelial cells (HCAEC). We aimed to investigate the effects of TNF-α inhibitor infliximab and anti-infliximab antibod...
Wen, Yichuan Ahmad, Feroz Mohri, Zahra Weinberg, Peter D Leake, David S
Published in
Atherosclerosis
We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein oxidation product ceroid. We have now used sphingomyelinase-aggregated LDL, a more pathophysiological form of aggregated LDL, to study lysosomal oxidation of LDL and ...
Gomez, Andrea Colombo, Roberto Pontoglio, Alessandro Helman, Lorena Kaeser, Luciana Giunta, Gustavo Parolin, Maria L Toscanini, Ulises Cuniberti, Luis
Published in
Atherosclerosis
Familial hypercholesterolemia (FH) is a primary hyperlipemia. It is an autosomal dominant genetic disorder of lipoproteins metabolism mainly caused by mutations in the low density lipoprotein receptor gene (LDLR). We aimed to investigate the functional impact on the low density lipoprotein receptor (LDLR) activity of six uncharacterised variants lo...
Wang, Xue-Bin Cui, Ning-Hua Liu, Xia'nan Ming, Liang
Published in
Atherosclerosis
We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. In the discovery phase, a public blood-based microa...
Lamiquiz-Moneo, Itziar Restrepo-Córdoba, María Alejandra Mateo-Gallego, Rocío Bea, Ana María Del Pino Alberiche-Ruano, María García-Pavía, Pablo Cenarro, Ana Martín, Cesar Civeira, Fernando Sánchez-Hernández, Rosa María
...
Published in
Atherosclerosis
Autosomal dominant familial hypercholesterolemia (FH) is caused by mutations in LDLR,APOB and PCSK9. Two new putative loci causing FH have been identified recently, the p.(Leu167del) mutation in APOE and new mutations in the signal transducing adaptor family member STAP1. We aimed at investigating the role of STAP1 mutations in the etiology of FH. ...
Li, Wenyuan Shu, Shan Cheng, Lele Hao, Xiang Wang, Lijun Wu, Yue Yuan, Zuyi Zhou, Juan
Published in
Atherosclerosis
Bile acids play important roles in lipid metabolism. Several studies have found that patients with coronary artery disease (CAD) have lower bile acid fecal excretion compared to individuals without CAD. However, few studies have focused on the roles of more accessible serum total bile acids (TBA) in the progression of CAD. The aim of this study was...
Son, Da-Hye Lee, Hye Sun Lee, Yong-Jae
Published in
Atherosclerosis
Leukoaraiosis refers to lesions with high signal intensity on magnetic resonance imaging (MRI) in periventricular and subcortical white matter that results from chronic microvascular ischemic brain damage. Increasing evidence suggests that serum CA 19-9 is associated with non-malignant conditions including type 2 diabetes, dyslipidemia, and metabol...
Masuda, Daisaku Miyata, Yuko Matsui, Shingo Yamashita, Shizuya
Published in
Atherosclerosis
We aimed to investigate blood lipid and lipoprotein profiles in patients with dyslipidemia receiving hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) after 8 weeks of omega-3 fatty acid ethyl esters (Omega-3) treatment, using high-performance liquid chromatography with highly-sensitive gel filtration columns. In this phase 4, randomi...
Jeon, Jooeun Kim, Dae Hyun Kim, Woojin Choi, Dong-Woo Jung, Keum Ji Jang, Sung-In
Published in
Atherosclerosis
The value of gamma-glutamyltransferase (GGT) in the putative mechanisms underlying its association with cardiovascular disease is unclear. This study examined whether serum GGT value has an independent association and dose-response relationship with the risk of atherosclerotic cardiovascular disease (ASCVD). This observational study included 419,43...
Ramaswami, Uma Futema, Marta Bogsrud, Martin P Holven, Kirsten B Roeters van Lennep, Jeanine Wiegman, Albert Descamps, Olivier S Vrablik, Michal Freiberger, Tomas Dieplinger, Hans
...
Published in
Atherosclerosis
For children with heterozygous familial hypercholesterolaemia (HeFH), European guidelines recommend consideration of statin therapy by age 8-10 years for those with a low density lipoprotein cholesterol (LDL-C) >3.5 mmol/l, and dietary and lifestyle advice. Here we compare the characteristics and lipid levels in HeFH children from Norway, UK, Nethe...
