Nemoto, Teruyoshi Minami, Yoshiyasu Yamaoka-Tojo, Minako Kato, Ayami Katsura, Aritomo Sato, Toshimitsu Muramatsu, Yusuke Kakizaki, Ryota Fujiyoshi, Kazuhiro Hashimoto, Takuya
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Published in
Atherosclerosis
Endothelial glycocalyx covers the endothelium and maintains vascular integrity. However, its association with the severity and vulnerability of coronary artery disease (CAD) remains to be elucidated. A total of 259 consecutive patients with stable CAD requiring percutaneous coronary intervention (PCI) were prospectively enrolled. Patients were clas...
Griffin, Kathryn J. Newell, Laura M. Simpson, Kingsley R. Beckers, Cora M.L. Drinkhill, Mark J. Standeven, Kristina F. Cheah, Lih T. Iismaa, Siiri E. Grant, Peter J. Jackson, Christopher L.
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Published in
Atherosclerosis
• Double transglutaminase 2 and Factor XIII-A knockout exacerbates cardiac fibrosis. • Double knockout does not promote the growth of, or destabilise, brachiocephalic plaques. • FXIII-A in resident cardiac macrophages does not protect against cardiac fibrosis. • FXIII-A in inflammatory macrophages may contribute to protection against fibrosis. • Tr...
Ramaswami, Uma Futema, Marta Bogsrud, Martin P Holven, Kirsten B Roeters van Lennep, Jeanine Wiegman, Albert Descamps, Olivier S Vrablik, Michal Freiberger, Tomas Dieplinger, Hans
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Published in
Atherosclerosis
For children with heterozygous familial hypercholesterolaemia (HeFH), European guidelines recommend consideration of statin therapy by age 8-10 years for those with a low density lipoprotein cholesterol (LDL-C) >3.5 mmol/l, and dietary and lifestyle advice. Here we compare the characteristics and lipid levels in HeFH children from Norway, UK, Nethe...
Hicks, Caitlin W Daya, Natalie R Black, James H 3rd Matsushita, Kunihiro Selvin, Elizabeth
Published in
Atherosclerosis
The indications for carotid endarterectomy (CEA) are well established. The aim of the current study was to investigate sex and race-based disparities in the incidence of CEA after adjusting for carotid artery stenosis risk factors. We conducted a prospective cohort analysis of 14,492 black and white participants in the Atherosclerosis Risk in Commu...
Wu, Zhi-yuan Trenner, Matthias Boon, Reinier A. Spin, Joshua M. Maegdefessel, Lars
Published in
Atherosclerosis
• This current review covers studies that have identified long non-coding RNAs in aortic aneurysm development and progression. • We separately discuss transcripts and mechanisms of importance to thoracic as well as abdominal aortic aneurysms. • Functional data on lncRNAs being identified are highlighted. • Some have been studied in human as well as...
Heffron, Sean P Dwivedi, Aeshita Rockman, Caron B Xia, Yuhe Guo, Yu Zhong, Judy Berger, Jeffrey S
Published in
Atherosclerosis
An independent association of body mass index (BMI) with atherosclerotic cardiovascular disease is somewhat controversial and may differ by vascular bed. Sex-specific risk factors for atherosclerosis may further modify these associations. Obesity and peripheral artery disease (PAD) are both more prevalent in women. We sought to determine the associ...
Ogrič, Manca Poljšak, Katjuša Mrak Lakota, Katja Žigon, Polona Praprotnik, Sonja Semrl, Snezna Sodin Čučnik, Saša
Published in
Atherosclerosis
Patients with rheumatic diseases have an increased risk of atherosclerosis with up-regulated serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which were reported to activate human coronary artery endothelial cells (HCAEC). We aimed to investigate the effects of TNF-α inhibitor infliximab and anti-infliximab antibod...
Wen, Yichuan Ahmad, Feroz Mohri, Zahra Weinberg, Peter D Leake, David S
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Atherosclerosis
We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein oxidation product ceroid. We have now used sphingomyelinase-aggregated LDL, a more pathophysiological form of aggregated LDL, to study lysosomal oxidation of LDL and ...
Gomez, Andrea Colombo, Roberto Pontoglio, Alessandro Helman, Lorena Kaeser, Luciana Giunta, Gustavo Parolin, Maria L Toscanini, Ulises Cuniberti, Luis
Published in
Atherosclerosis
Familial hypercholesterolemia (FH) is a primary hyperlipemia. It is an autosomal dominant genetic disorder of lipoproteins metabolism mainly caused by mutations in the low density lipoprotein receptor gene (LDLR). We aimed to investigate the functional impact on the low density lipoprotein receptor (LDLR) activity of six uncharacterised variants lo...
Wang, Xue-Bin Cui, Ning-Hua Liu, Xia'nan Ming, Liang
Published in
Atherosclerosis
We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. In the discovery phase, a public blood-based microa...
