Published in Atherosclerosis
Over the past fifteen years, treatments using monoclonal antibodies specifically targeting cytokines have been developed to treat chronic inflammatory diseases, including rheumatoid arthritis or psoriasis, both associated with increased cardiovascular risk. The cardiovascular impact of these therapies allows us to validate the clinical relevance of...
Published in Atherosclerosis
Published in Atherosclerosis
Published in Atherosclerosis
• Endothelial cells exposed to atheroprotective flow secrete FSTL1. • FSTL1 reduces transendothelial transport of LDL and LDL-sized tracers. • FSTL1 reduces the pro-inflammatory effects of TNF-α.
Published in Atherosclerosis
Targeting the modifiable risk factors for coronary artery disease (CAD) has substantial impact at the community level. However, it is not uncommon for individuals to present with atherosclerosis related events without identified risk factors. We examined sex differences in the association of risk factors and atherosclerotic burden assessed by CT co...
Published in Atherosclerosis
Symptomatic peripheral artery disease (PAD) is a risk factor for abdominal aortic aneurysm (AAA). However, data on the association of asymptomatic PAD with AAA are limited. We explored the association of symptomatic and asymptomatic PAD with AAA. We primarily assessed a prospective association of symptomatic (based on clinical history) and asymptom...
Published in Atherosclerosis
Both low appendicular skeletal muscle index (ASMI) and specific abdominal fat composition [i.e., increased visceral to subcutaneous (V/S) fat ratio] have been associated with cardiovascular events. However, the combined impact of these 2 components on long-term outcomes remains unclear, especially in patients with ST-segment elevation myocardial in...
Published in Atherosclerosis
Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be ...
Published in Atherosclerosis
Published in Atherosclerosis
