Cho, In Young Chang, Yoosoo Sung, Eunju Kim, Yejin Kang, Jae-Heon Shin, Hocheol Wild, Sarah H Byrne, Christopher D Ryu, Seungho
Published in
Atherosclerosis
Increased levels of ketone bodies, an alternative fuel when glucose availability is low, may exert beneficial effects on cardiovascular disease (CVD) risk factors. Whether increased ketone bodies are associated with coronary artery calcium (CAC), a recognized and strong cardiovascular risk factor, remains unknown. We investigated the association of...
Dang, Anh-Thu Turner, Adam W Lau, Paulina Mohottalage, Dhanuddara Stephanie Fong, Yuet Kay Eriksson, Per Folkersen, Lasse Matic, Ljubica Hedin, Ulf Soubeyrand, Sébastien
...
Published in
Atherosclerosis
Genome-wide association studies (GWAS) identified a coronary artery disease (CAD) risk locus on 13.q34 tagged by rs61969072 (T/G). This variant lies in an intergenic region, proximal to ING1, CARKD and CARS2 but its causal relationship to CAD is unknown. We first demonstrated that rs61969072 and tightly linked single nucleotide polymorphisms (SNPs)...
Song, Han Koh, Youngil Rhee, Tae-Min Choi, Su-Yeon Kang, Shinae Lee, Seung-Pyo
Published in
Atherosclerosis
Studies have demonstrated that the risk of atherosclerotic cardiovascular disease (ASCVD) can be assessed by polygenic risk score (PRS) using common genetic variants. Because metabolic syndrome is a well-known, robust risk factor of ASCVD, we established PRS of metabolic disease and analyzed whether this PRS could predict incident ASCVD. We constru...
Wenning, Christian Kloth, Christopher Kuhlmann, Michael T. Jacobs, Andreas H. Schober, Otmar Hermann, Sven Schäfers, Michael A.
Published in
Atherosclerosis
•F-18-FDG-PET/CT identifies inflamed, shear-stress induced plaques in vivo.•PET/CT distinguishes inflamed plaques from non-inflamed plaques in a single mouse model.•Maximum inflammatory activity is detected in plaques with an unstable phenotype.•F-18-FDG uptake correlates with plaque size and macrophage density within the plaques.
Villa-Roel, Nicolas Ryu, Kitae Gu, Lina Fernandez Esmerats, Joan Kang, Dong-Won Kumar, Sandeep Jo, Hanjoong
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Atherosclerosis
Hypoxia inducible factor 1α (HIF1α) plays a critical role in atherosclerosis as demonstrated in endothelial-targeted HIF1α -deficient mice. However, it has not been shown if specific pharmacological inhibitors of HIF1α can be used as potential drugs for atherosclerosis. PX-478 is a selective inhibitor of HIF1α, which was used to reduce cancer and o...
Mostaza, Jose M. Salinero-Fort, Miguel A. Cardenas-Valladolid, Juan Rodriguez-Artalejo, Fernando Díaz-Almiron, Mariana Vich-Pérez, Pilar San Andres-Rebollo, F.Javier Vicente, Ignacio Lahoz, Carlos
Published in
Atherosclerosis
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Nurmohamed, Nick S. Collard, Didier Reeskamp, Laurens F. Kaiser, Yannick Kroon, Jeffrey Tromp, Tycho R. van den Born, Bert-Jan H. Coppens, Michiel Vlaar, Alexander P.J. Beudel, Martijn
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Published in
Atherosclerosis
Image 1
Schill, Fredrika Persson, Margaretha Engström, Gunnar Melander, Olle Enhörning, Sofia
Published in
Atherosclerosis
The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. In this population-based, cross-secti...
de Lusignan, Simon
Published in
Atherosclerosis
Liu, Mengjiao Lovern, Claire Lycett, Kate He, Mingguang Wake, Melissa Wong, Tien Yin Burgner, David P
Published in
Atherosclerosis
Adverse changes to the microcirculation play an important role in the pathogenesis of cardiovascular disease (CVD), and inflammation is a key causal mechanism. We investigated the relationship between inflammatory markers and retinal microvascular parameters. Studies up to April 2021 were identified in Medline, Embase and PubMed with the following ...