Published in Atherosclerosis
Increased levels of ketone bodies, an alternative fuel when glucose availability is low, may exert beneficial effects on cardiovascular disease (CVD) risk factors. Whether increased ketone bodies are associated with coronary artery calcium (CAC), a recognized and strong cardiovascular risk factor, remains unknown. We investigated the association of...
Published in Atherosclerosis
Genome-wide association studies (GWAS) identified a coronary artery disease (CAD) risk locus on 13.q34 tagged by rs61969072 (T/G). This variant lies in an intergenic region, proximal to ING1, CARKD and CARS2 but its causal relationship to CAD is unknown. We first demonstrated that rs61969072 and tightly linked single nucleotide polymorphisms (SNPs)...
Published in Atherosclerosis
Studies have demonstrated that the risk of atherosclerotic cardiovascular disease (ASCVD) can be assessed by polygenic risk score (PRS) using common genetic variants. Because metabolic syndrome is a well-known, robust risk factor of ASCVD, we established PRS of metabolic disease and analyzed whether this PRS could predict incident ASCVD. We constru...
Published in Atherosclerosis
•F-18-FDG-PET/CT identifies inflamed, shear-stress induced plaques in vivo.•PET/CT distinguishes inflamed plaques from non-inflamed plaques in a single mouse model.•Maximum inflammatory activity is detected in plaques with an unstable phenotype.•F-18-FDG uptake correlates with plaque size and macrophage density within the plaques.
Published in Atherosclerosis
Hypoxia inducible factor 1α (HIF1α) plays a critical role in atherosclerosis as demonstrated in endothelial-targeted HIF1α -deficient mice. However, it has not been shown if specific pharmacological inhibitors of HIF1α can be used as potential drugs for atherosclerosis. PX-478 is a selective inhibitor of HIF1α, which was used to reduce cancer and o...
Published in Atherosclerosis
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Published in Atherosclerosis
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Published in Atherosclerosis
The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. In this population-based, cross-secti...
Published in Atherosclerosis
Published in Atherosclerosis
Adverse changes to the microcirculation play an important role in the pathogenesis of cardiovascular disease (CVD), and inflammation is a key causal mechanism. We investigated the relationship between inflammatory markers and retinal microvascular parameters. Studies up to April 2021 were identified in Medline, Embase and PubMed with the following ...
