Iqbal, Zohaib Ho, Jan Hoong Adam, Safwaan France, Michael Syed, Akheel Neely, Dermot Rees, Alan Khatib, Rani Cegla, Jaimini Byrne, Christopher
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Published in
Atherosclerosis
• Patients with known atherosclerotic cardiovascular disease and related comorbidities are at increased risk of severe illness and mortality if infected with COVID-19. • There is no convincing evidence to suggest harm from lipid lowering therapy or on-treatment low LDL cholesterol if patients develop acute illnesses or SARS-CoV-2. In fact, availabl...
Stock, Jane K
Published in
Atherosclerosis
Huang, Yitao Urabe, Go Zhang, Mengxue Li, Jing Ozer, Hatice Gulcin Wang, Bowen Kent, K Craig Guo, Lian-Wang
Published in
Atherosclerosis
Histone methyltransferases are emerging targets for epigenetic therapy. DOT1L (disruptor of telomeric silencing 1-like) is the only known methylation writer at histone 3 lysine 79 (H3K79). It is little explored for intervention of cardiovascular disease. We investigated the role of DOT1L in neointimal hyperplasia (IH), a basic etiology of occlusive...
Villa-Bellosta, Ricardo
Published in
Atherosclerosis
Cardiovascular complications due to accelerated atherosclerosis and arterial stiffening are the leading cause of morbidity and mortality in the Western society. Both pathologies are frequently associated with vascular calcification. Deposits of calcium phosphate salts, mainly in form of hydroxyapatite, is the hallmark of vascular calcification. Cal...
Passos, Livia S A Lupieri, Adrien Becker-Greene, Dakota Aikawa, Elena
Published in
Atherosclerosis
Despite the focus placed on cardiovascular research, the prevalence of vascular and valvular calcification is increasing and remains a leading contributor of cardiovascular morbidity and mortality. Accumulating studies provide evidence that cardiovascular calcification is an inflammatory disease in which innate immune signaling becomes sustained an...
Jung, Inha Kwon, Hyemi Park, Se Eun Park, Cheol-Young Lee, Won-Young Oh, Ki-Won Park, Sung-Woo Rhee, Eun-Jung
Published in
Atherosclerosis
High lipoprotein(a) [Lp(a)] levels are associated with increased risk of cardiovascular disease. However, the association between Lp(a) and fatty liver disease (FLD) remains controversial. Therefore, we analyzed the relationship between FLD and serum Lp(a) levels in Korean adults. A total of 22,534 participants who underwent a routine health screen...
Pasta, Andrea Cremonini, Anna Laura Formisano, Elena Fresa, Raffaele Bertolini, Stefano Pisciotta, Livia
Published in
Atherosclerosis
In Italy, the clinical and genetic characteristics of familial hypercholesterolemia (FH) have been extensively assessed in various lipid clinics, although no studies on long-term cardiovascular outcomes in heterozygous patients (He-FH) have been conducted. This study evaluated the incidence of atherosclerotic cardiovascular disease (ASCVD) in He-FH...
Navel, Valentin
Published in
Atherosclerosis
Porter, Thomas
Published in
Atherosclerosis
Nemoto, Teruyoshi Minami, Yoshiyasu Yamaoka-Tojo, Minako Kato, Ayami Katsura, Aritomo Sato, Toshimitsu Muramatsu, Yusuke Kakizaki, Ryota Fujiyoshi, Kazuhiro Hashimoto, Takuya
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Published in
Atherosclerosis
Endothelial glycocalyx covers the endothelium and maintains vascular integrity. However, its association with the severity and vulnerability of coronary artery disease (CAD) remains to be elucidated. A total of 259 consecutive patients with stable CAD requiring percutaneous coronary intervention (PCI) were prospectively enrolled. Patients were clas...
