Guédon, Alexis F. Catano, Jennifer Ricard, Laure Laurent, Charlotte de Moreuil, Claire Urbanski, Geoffrey Deriaz, Sophie Gerotziafas, Grigorios Elalamy, Ismail Audemard, Alexandra
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Arthritis Research & Therapy
BackgroundFrom this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) and (2) determine their prognostic value.MethodsThis retrospective French multicenter cohort study included all patients diagnosed with p-APS (Sydney criteria) between January 201...
Vittecoq, Olivier Guillou, Clément Hardouin, Julie Gerard, Baptiste Berenbaum, Francis Constantin, Arnaud Rincheval, Nathalie Combe, Bernard Lequerre, Thierry Cosette, Pascal
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Arthritis Research & Therapy
Background To validate the ability of PROS (vitamin K-dependent protein S) and CO7 (complement component C7) to predict response to the methotrexate (MTX)/etanercept (ETA) combination in rheumatoid arthritis (RA) patients who received this therapeutic combination in a well-documented cohort. Method From the ESPOIR cohort, RA patients having receive...
Queiro, Rubén Seoane-Mato, Daniel Laiz, Ana Agirregoikoa, Eva Galíndez Montilla, Carlos Park, Hye-Sang Pinto-Tasende, Jose A. Bethencourt Baute, Juan J. Ibáñez, Beatriz Joven Toniolo, Elide
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Arthritis Research & Therapy
Background Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adverse course of PsA are more likely to succeed if we intervene early. In the present study, we used predictive models based on mach...
Bergman, Martin Tundia, Namita Martin, Naomi Suboticki, Jessica L. Patel, Jayeshkumar Goldschmidt, Debbie Song, Yan Wright, Grace C.
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Arthritis Research & Therapy
Background In previous clinical trials, patients with active rheumatoid arthritis (RA) treated with upadacitinib (UPA) have improved patient-reported outcomes (PROs). This post hoc analysis of SELECT-CHOICE, a phase 3 clinical trial, evaluated the impact of UPA vs abatacept (ABA) with background conventional synthetic disease-modifying antirheumati...
Dakkak, Yousra J. van Dijk, Bastiaan T. Jansen, Friso P. Wisse, Lambertus J. Reijnierse, Monique van der Helm-van Mil, Annette H. M. DeRuiter, Marco C.
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Arthritis Research & Therapy
MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inflammation is called ‘peritendinitis’ since anatomy literature reports no presence of a tenosynovial sheath at these tendons. However, the pre...
Port, Helena Nielsen, Signe Holm Madsen, Sofie Falkenløve Bay-Jensen, Anne-Christine Karsdal, Morten Seven, Sengül Sørensen, Inge Juul Morsel-Carlsen, Lone Østergaard, Mikkel Pedersen, Susanne Juhl
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Arthritis research & therapy
Axial spondyloarthritis (axSpA) is a common chronic inflammatory disease, associated with extracellular matrix (ECM) remodeling of the cartilage, bone, and connective tissues. The primary symptom of axSpA is back pain, caused by inflammation. However, there is a medical need to truly identify patients with axSpA from other subjects with buttock or ...
Zhao, Naizhuo Smargiassi, Audrey Jean, Sonia Gamache, Philippe Laouan-Sidi, Elhadji-Anassour Chen, Hong Goldberg, Mark S Bernatsky, Sasha
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Arthritis research & therapy
To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs). An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren's syndrome, scleroderma,...
Sreedharan, Sidha Li, Ning Littlejohn, Geoff Buchanan, Russell Nikpour, Mandana Morand, Eric Hoi, Alberta Golder, Vera
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Arthritis Research & Therapy
Background Healthcare quality for systemic lupus erythematosus (SLE) is a modifiable target for improving patient outcomes. We aimed to assess the quality of care processes in different clinic settings, comparing a subspecialty lupus clinic with hospital-based and private general rheumatology clinics. Methods Patients with SLE ( n = 258) were recru...
Tian, Xue Zuo, Yingting Chen, Shuohua Wu, Shouling Wang, Anxin Luo, Yanxia
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Arthritis Research & Therapy
Background Long-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly characterized as prior studies measured SUA at a single time point. This study aimed to identify SUA trajectories and determine their associations with incident MI and all-cause mortality. Methods We incl...
Zhang, Li Zheng, Dong Yan, Yuemei Yu, Yong Chen, Ruizhen Li, Zheng Greer, Peter A. Peng, Tianqing Wang, Qiang
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Arthritis Research & Therapy
Background Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the role of calpain in interstitial lung disease (ILD) has not been reported. ILD is a severe complication of SS...
