Lin, Hilène Ah Kioon, Marie-Dominique Lalou, Claude Larghero, Jerome Launay, Jean-Marie Khatib, Abdel-Majid Martine Cohen-Solal
Published in
Arthritis & Rheumatism
These findings show the protective role of exogenous furin against RA, mediated by an immune response. The data suggest the potential therapeutic use of furin or its derivatives in autoimmune diseases including RA.
Terrier, Benjamin Geri, Guillaume Chaara, Wahiba Allenbach, Yves Rosenzwajg, Michelle Costedoat-Chalumeau, Nathalie Fouret, Pierre Musset, Lucile Benveniste, Olivier Six, Adrien
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Published in
Arthritis & Rheumatism
Our findings indicate that IL-21 plays a critical role in modulating Th1 and Th17 responses and Treg cells in GCA, and might represent a potential target for novel therapy.
Ah Kioon, Marie-Dominique Asensio, Carine Ea, Hang-Korng Velard, Frédéric Uzan, Benjamin Rullé, Sandrine Bazille, Céline Marty, Caroline Falgarone, Géraldine Nguyen, Christelle
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Published in
Arthritis & Rheumatism
Objective: Adrenomedullin(22-52) is a truncated peptide derived from adrenomedullin, a growth factor with antiapoptotic and immunoregulatory properties. It can act as an agonist or an antagonist depending on cell type. Its in vivo effects are unknown, but adrenomedullin(22-52) could possess immunomodulatory properties. This study was undertaken to ...
Nicholls, Alex S Kiran, Amit Pollard, Thomas C B Hart, Deborah J Arden, Charlotte P A Spector, Tim Gill, H S Murray, David W Carr, Andrew J Arden, Nigel K
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Published in
Arthritis and rheumatism
This investigation describes measurements that predict the risk of THA for end-stage OA by year 20, independently of the presence of radiographic hip OA at year 2. These measurements can be made on an anteroposterior pelvis radiograph, which is an inexpensive and commonly used clinical method of investigation.
Genovese, M C Covarrubias, A Leon, G Mysler, E Keiserman, M Valente, R Nash, P Simon-Campos, J A Porawska, W Box, J
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Published in
Arthritis and rheumatism
To compare the efficacy and safety of subcutaneous (SC) and intravenous (IV) abatacept. In this phase IIIb double-blind, double-dummy, 6-month study, patients with rheumatoid arthritis (RA) and inadequate responses to methotrexate were randomized to receive 125 mg SC abatacept on days 1 and 8 and weekly thereafter (plus an IV loading dose [∼10 mg/k...
Clinch, Jacqui Deere, Kevin Sayers, Adrian Palmer, Shea Riddoch, Chris Tobias, Jonathan H Clark, Emma M
Published in
Arthritis and rheumatism
We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and ...
Valdes, Ana M Spector, Tim D Tamm, Agu Kisand, Kalle Doherty, Sally A Dennison, Elaine M Mangino, Massimo Tamm, Ann Kerna, Irina Hart, Deborah J
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Published in
Arthritis and rheumatism
Our data indicate that genetic variation in the SMAD3 gene is involved in the risk of both hip OA and knee OA in European populations, confirming the results from animal models on the potential importance of this molecule in the pathogenesis of OA.
Dhaenens, Maarten Fert, Ingrid Glatigny, Simon Haerinck, Saskia Poulain, Cécile Emmanuel Donnadieu Hacquard-Bouder, Cécile André, Claudine Elewaut, Dirk Deforce, Dieter
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Published in
Arthritis & Rheumatism
Objective. Spondylarthritis (SpA) is characterized by spinal and peripheral joint inflammation, frequently combined with extraarticular manifestations. Despite the well-established association of SpA with the class I major histocompatibility complex (MHC) allele HLA-B27, there are still different, parallel hypotheses on the relationship between HLA...
Livshits, Gregory Zhai, Guangju Hart, Deborah J Kato, Bernet S Wang, Huizhong Williams, Frances M K Spector, Tim D
Published in
Arthritis and rheumatism
This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.
Evangelou, Evangelos Chapman, Kay Meulenbelt, Ingrid Karassa, Fotini B Loughlin, John Carr, Andrew Doherty, Michael Doherty, Sally Gómez-Reino, Juan J Gonzalez, Antonio
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Published in
Arthritis and rheumatism
GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of the GDF5 gene or the rs7775 and rs288326 polymorphisms of the FRZB gene have been conflicting or inconclusive. To examine these associations,...