Yan, Yan Zhang, Li Zuo, Yun Qian, Heya Liu, Chang
Published in
Archivum Immunologiae et Therapiae Experimentalis
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are critical for the regulation of T cell exhaustion and activity suppression. Tumor cells expressing immune checkpoints including PD-L1 escape monitoring of T cells from the host immune system. Checkpoint inhibitors are highly promising therapies that function as tumor-suppressing factors...
Piasecki, Egbert
Published in
Archivum Immunologiae et Therapiae Experimentalis
The COVID-19 pandemic developing rapidly in 2020 is triggered by the emergence of a new human virus—SARS-CoV-2. The emergence of a new virus is not an unexpected phenomenon and has been predicted for many years. Since the virus has spread all over the world, it will be very difficult or even impossible to eradicate it. A necessary condition for com...
Skorka, Katarzyna Ostapinska, Katarzyna Malesa, Aneta Giannopoulos, Krzysztof
Published in
Archivum Immunologiae et Therapiae Experimentalis
Chimeric antigen receptor (CAR)-T cells (CART) remain one of the most advanced and promising forms of adoptive T-cell immunotherapy. CART represent autologous, genetically engineered T lymphocytes expressing CAR, i.e. fusion proteins that combine components and features of T cells as well as antibodies providing their more effective and direct anti...
Liu, Feng Ran, Fang He, Hongqin Chen, Linyun
Published in
Archivum Immunologiae et Therapiae Experimentalis
Astragaloside IV (AS-IV) has shown anti-tumorigenic properties in certain cancers for its effect of boosting the body’s immune system, but its role in colorectal cancer (CRC) remains unclear. In this study, we investigated the therapeutic effect of AS-IV in CRC and explored its underlying mechanism. CT26 colon cancer cells and mouse model by inject...
Ratajczak-Wrona, Wioletta Wawrusiewicz-Kurylonek, Natalia Garley, Marzena Kretowski, Adam Jacek Jablonska, Ewa
Published in
Archivum Immunologiae et Therapiae Experimentalis
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring tumorigenesis. APRIL is important fitness and survival factors for B cells and plasma cells in the periphery. Considering this, as well as the quantitative predominance of neutrophils among the peripheral blood...
Eleftheriadis, Theodoros Pissas, Georgios Mavropoulos, Athanasios Nikolaou, Evdokia Filippidis, Georgios Liakopoulos, Vassilios Stefanidis, Ioannis
Published in
Archivum Immunologiae et Therapiae Experimentalis
Hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitors are currently used for the treatment of renal anemia. Since HIF affects immune cells, we evaluated the effect of such a drug, the roxadustat, on adaptive immunity. Cell proliferation was assessed in a two-way mixed lymphocyte reaction (MLR) with BrdU assay. In CD4+ T cells isolated from t...
Donskow-Łysoniewska, Katarzyna Krawczak, Katarzyna Machcińska, Maja Brodaczewska, Klaudia
Published in
Archivum Immunologiae et Therapiae Experimentalis
An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent i...
Żeromski, Jan Kierepa, Agata Brzezicha, Bartosz Kowala-Piaskowska, Arleta Mozer-Lisewska, Iwona
Published in
Archivum Immunologiae et Therapiae Experimentalis
Pattern recognition receptors (PRRs) are a pivotal part of the immune system. They are distributed in almost every site of higher organisms, able to recognize foreign pathogens or unwanted remnants of metabolism and mount innate immune response. Moreover, PRRs create bridging signaling to initiate adaptive immunity. The liver being the largest orga...
Zborowska-Piskadło, Karolina Stachowiak, Małgorzata Rusetska, Natalia Sarnowska, Elżbieta Siedlecki, Janusz Dżaman, Karolina
Published in
Archivum Immunologiae et Therapiae Experimentalis
Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, the bitter taste receptor TAS2R38 has been described to play a role in upper airway innate mucosal defense. The aim was to determine the localization and expression of the TAS2R38 in the selected cell lines and tissue collected from...
Sisto, Margherita Tamma, Roberto Ribatti, Domenico Lisi, Sabrina
Published in
Archivum Immunologiae et Therapiae Experimentalis
To determine the role of IL-6 in bringing about the EMT, in SGEC obtained from healthy subjects. Human salivary gland (SGs) epithelial cells (SGEC) from primary Sjögren’s syndrome (pSS) are able to synthesize interleukin (IL)-6, which is a critical mediator of the SGs modifications in response to chronic inflammation. Recently, a hypothetical link ...
