Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibiti...
Published in Archives of Biochemistry and Biophysics
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Understanding the influence of experimental factors on bio-interactions of nanoparticles: Towards improving correlation ...
Published in Archives of Biochemistry and Biophysics
• Inorganic/metallic core nanoparticles comprise 25% of the nanomedicines in clinical trials. • Nano-bio interactions are complex and lack of standardization in the field further limits their transition to clinical trials and beyond. • Experimental parameters play an important role along with the nanoparticle physicochemical properties in understan...
Comprehensive biomedical applications of low temperature plasmas
Published in Archives of Biochemistry and Biophysics
• Low-temperature plasma (LTP) has antibacterial and antifungal effects against oral biofilms. • LTP has wound healing effects and antimicrobial effects on skin diseases. • LTP has direct and indirect effects on different types of cancer. • LTP inactivates or lowers viral load of different types of viruses. • LTP improves the osseointegration to de...
Acute phase protein response to viral infection and vaccination.
Published in Archives of biochemistry and biophysics
Organisms respond in multiple ways to microbial infections. Pathogen invasion tipically triggers an inflammatory response where acute phase proteins (APP) have a key role. Pentraxins (PTX) are a family of highly conserved APP that play a part in the host defense against infection. The larger proteins of the family are simply named pentraxins, while...
Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation.
Published in Archives of biochemistry and biophysics
Severe inflammation may lead to multiple organs dysfunction syndrome, which has a high mortality. MicroRNA is found participated in this process. In this study we developed a lipopolysaccharide-induced inflammation cell model on macrophages and a lipopolysaccharide-induced inflammation mouse model. It was found that during inflammation, microRNA-9 ...
Atomic force microscopy for single molecule characterisation of protein aggregation.
Published in Archives of biochemistry and biophysics
The development of atomic force microscopy (AFM) has opened up a wide range of novel opportunities in nanoscience and new modalities of observation in complex biological systems. AFM imaging has been widely employed to resolve the complex and heterogeneous conformational states involved in protein aggregation at the single molecule scale and shed l...
Pre-structured hydrophobic peptide β-strands: A universal amyloid trap?
Published in Archives of biochemistry and biophysics
Amyloid fibril formation has long been studied because of the variety of proteins that are capable of adopting this structure despite sharing little sequence homology. This makes amyloid fibrils a challenging focus for inhibition studies because the peptides and proteins that form amyloid fibrils cannot be targeted based on a sequence motif. Most p...
Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: What have we learned ...
Published in Archives of Biochemistry and Biophysics
Research into the mechanisms by which proteins fold into their native structures has been on-going since the work of Anfinsen in the 1960s. Since that time, the folding mechanisms of small, water-soluble proteins have been well characterised. By contrast, progress in understanding the biogenesis and folding mechanisms of integral membrane proteins ...
Hypoxic conditions differentially regulate TAZ and YAP in cancer cells.
Published in Archives of biochemistry and biophysics
The Hippo-YAP pathway is altered and implicated as an oncogenic signaling pathway in many human cancers. Hypoxia is an important microenvironmental factor that promotes tumorigenesis. However, the effects of hypoxia on the two most important Hippo-YAP effectors, YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding mot...
Reprint of: The Great Beauty of the osteoclast.
Published in Archives of biochemistry and biophysics
Much has been written recently on osteoclast biology, but this cell type still astonishes scientists with its multifaceted functions and unique properties. The last three decades have seen a change in thinking about the osteoclast, from a cell with a single function, which just destroys the tissue it belongs to, to an "orchestrator" implicated in t...
