Yin, Xuejiao Chen, Hongdan Sun, Guowei Xu, Yangxing Wang, Lingna
Published in
Applied biochemistry and biotechnology
Atherosclerosis (AS) is one of the most common and important vascular diseases. It is believed that the abnormal expression of circular RNAs (circRNAs) plays an important role in AS. Hence, we investigate the function and mechanism of circ-C16orf62 in AS development.In this study, oxidized low-density lipoprotein (ox-LDL)-treated human macrophages ...
Khushboo, Dubey, Kashyap Kumar
Published in
Applied biochemistry and biotechnology
Lipstatin, natural inhibitor of pancreatic lipase produced by Streptomyces toxytricini and used as an anti-obesity drug. Chemical mutagenesis was performed with different concentrations of N-methyl-N'-nitro-N-nitrosoguanidine (NTG) for strain improvement to obtain high yield of lipstatin. It was observed that the potential of the wild type strain t...
Fan, Xiulin Zhang, Pingbo Fan, Mingming Jiang, Pingping Leng, Yan
Published in
Applied biochemistry and biotechnology
Immobilized lipase is a green and sustainable catalyst for hydrolysis of acidified oil. Glutaraldehyde is widely used for lipase immobilization while the appropriate strategy optimizes the catalytic performance of lipase. In this research, lipase from Candida rugosa (CRL) was immobilized on spherical silica (SiO2) by glutaraldehyde multipoint coval...
Yang, Ke Zheng, Wei-Wei Huang, Xiu-Song Chen, Kai-Ming Duan, Cai-Wen
Published in
Applied biochemistry and biotechnology
Antibody drugs have been widely used to treat many diseases and are the fastest-growing drug class. IgG1 is the most common type of antibody because of its good serum stability; however, effective methods for the rapid detection of IgG1-type antibodies are lacking. In this study, we designed two aptamer molecules derived from the reported aptamer p...
Simonič, Marjana Slapničar, Špela Trček, Janja Matijašić, Bojana Bogovič Lorbeg, Petra Mohar Vesel, Alenka Zemljič, Lidija Fras Peršin Fratnik, Zdenka
Published in
Applied biochemistry and biotechnology
Probiotics are live microorganisms that can have beneficial effects on humans. Encapsulation offers them a better chance of survival. Therefore, nozzle-free electrospinning was introduced for their embedding in nanofibrous material. Probiotic Lactobacillus paragasseri K7 in lyophilized and fresh form, with and without inulin as prebiotic, was added...
Kaari, Manigundan Joseph, Jerrine Manikkam, Radhakrishnan Kalyanasundaram, Revathy Sivaraj, Anbarasu Anbalmani, Sivarajan Murthy, Sangeetha Sahu, Amit Kumar Said, Madhukar Dastager, Syed G
...
Published in
Applied biochemistry and biotechnology
The aim of the present study is to identify actinobacteria Streptomyces bacillaris ANS2 as the source of the potentially beneficial compound 2,4-di-tert-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of S. bacillaris ANS2 to produ...
Xing, Dayuan Li, Li Meng, Di Zhang, Yanhui Ma, Feng
Published in
Applied biochemistry and biotechnology
Oral squamous cell carcinoma (OSCC), a global threatening disease, is reported mostly in the middle and elderly male population. Even though the exact cause of OSCC was not known, consumption of tobacco in any form has been reported in most of OSCC patients. OSCC is a massive invasive type of cancer which easily spreads to the distant organs. Hence...
Rahaman, Syed Nasar Pathmanapan, Srinivetha Sidharthan, Anbarasi Anandasadagopan, Suresh Kumar
Published in
Applied biochemistry and biotechnology
Orthopedic infections due to biofilm formation in biomaterial-based implants have become challenging in bone tissue engineering. In the present study, in vitro antibacterial analysis of amino-functionalized MCM-48 mesoporous silica nanoparticles (AF-MSNs) loaded with vancomycin is analyzed for its potential as a drug carrier for the sustained/contr...
Wang, Xifeng Chen, Pengxiao Li, Haifeng Qu, Jianhang Liu, Zhi
Published in
Applied biochemistry and biotechnology
Laccases are widespread multi-copper oxidases and generally classified into three-domain laccases and two-domain laccases. In this study, a novel laccase PthLac from Parageobacillus thermoglucosidasius harbored only one domain of Cu-oxidase_4 and showed no sequence relatedness or structure similarity to three-domain and two-domain laccases. PthLac ...
Priyanto, Jepri Agung Prastya, Muhammad Eka Astuti, Rika Indri Kristiana, Rhesi
Published in
Applied biochemistry and biotechnology
Endophytes associated with medicinal plants are a potential source of valuable natural products. This study aimed to evaluate the antibacterial and antibiofilm activities of endophytic bacteria from Archidendron pauciflorum against multidrug-resistant (MDR) strains. A total of 24 endophytic bacteria were isolated from the leaf, root, and stem of A....
